(Q38195518)

30 August 2017

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title

Adrenergic signaling in heart failure: a balance of toxic and protective effects (English)

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30 August 2017

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Anthony J Baker

1

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30 August 2017

publication date

14 March 2014

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30 August 2017

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30 August 2017

volume

466

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30 August 2017

issue

6

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30 August 2017

page(s)

1139-1150

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Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy

30 August 2017

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Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway

21 January 2018

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Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction.

21 January 2018

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Transgenic alpha1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival.

21 January 2018

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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

21 January 2018

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Deletion of the β2-adrenergic receptor prevents the development of cardiomyopathy in mice

21 January 2018

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Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart

21 January 2018

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Inotropic therapy for heart failure: an evidence-based approach.

21 January 2018

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alpha-adrenergic coronary vasoconstriction and myocardial ischemia in humans

21 January 2018

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Phosphorylation-dependent regulation of cardiac Na+/Ca2+ exchanger via protein kinase C.

21 January 2018

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Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study

21 January 2018

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{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium

21 January 2018

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The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries

21 January 2018

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Endothelium-dependent relaxation competes with alpha 1- and alpha 2-adrenergic constriction in the canine epicardial coronary microcirculation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.

21 January 2018

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Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure

21 January 2018

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Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure

21 January 2018

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Pathophysiology-based novel pharmacotherapy for heart failure with preserved ejection fraction.

21 January 2018

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Differential expression of cardiac neurotrophic factors and sympathetic nerve ending abnormalities within the failing heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Presynaptic regulation of catecholamine release

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Targeted alpha(1A)-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Adrenergic nervous system in heart failure: pathophysiology and therapy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Mechanisms and models in heart failure: the biomechanical model and beyond

21 January 2018

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Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy

21 January 2018

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alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI.

21 January 2018

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Region-specific neuropeptide Y overflows at rest and during sympathetic activation in humans.

21 January 2018

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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

21 January 2018

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Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload

21 January 2018

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The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

21 January 2018

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Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance

21 January 2018

1 reference

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Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST).

21 January 2018

1 reference

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The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Functional selectivity in adrenergic and angiotensin signaling systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Sympathetic activation in heart failure and its treatment with beta-blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Myocardial cyclic AMP and norepinephrine content in human heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Seven-transmembrane-spanning receptors and heart function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

alpha1A- but not alpha1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Cardiac GPCRs: GPCR signaling in healthy and failing hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Intracellular signalling through protein kinases in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Effects of sustained-release moxonidine, an imidazoline agonist, on plasma norepinephrine in patients with chronic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Plasma norepinephrine in congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Experimental catecholamine-induced myocardial necrosis. I. Morphology, quantification and regional distribution of acute contraction band lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Experimental catecholamine-induced myocardial necrosis. II. Temporal development of isoproterenol-induced contraction band lesions correlated with ECG, hemodynamic and biochemical changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Nuclear β-adrenergic receptors modulate gene expression in adult rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Left Ventricular Response to Severe Exertion in Untethered Dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Beta-arrestin-biased ligands at seven-transmembrane receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Myocyte adrenoceptor signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-014-1491-5

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure

21 January 2018

1 reference

12 December 2020

Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes

1 reference

12 December 2020

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1 reference

12 December 2020

Adverse effects of constitutively active alpha(1B)-adrenergic receptors after pressure overload in mouse hearts

1 reference

12 December 2020

Phosphorylation of a myofibrillar protein of Mr 150 000 in perfused rat heart, and the tentative indentification of this as C-protein

1 reference

12 December 2020

Cardiac-directed overexpression of wild-type alpha1B-adrenergic receptor induces dilated cardiomyopathy.

1 reference

12 December 2020

2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Deve

1 reference

12 December 2020

The Vasodilator-Heart Failure Trials (V-HeFT). Mechanistic data from the VA Cooperative Studies. Introduction.

1 reference

12 December 2020

Beta 1- and beta 2-adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure

1 reference

12 December 2020

Adrenergic effects on the biology of the adult mammalian cardiocyte

1 reference

12 December 2020

Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group

1 reference

12 December 2020

Role of PKC in the effects of alpha1-adrenergic stimulation on Ca2+ transients, contraction and Ca2+ current in guinea-pig ventricular myocytes

1 reference

12 December 2020

Adrenergic and muscarinic receptors in the human heart

1 reference

12 December 2020

alpha-Adrenoceptor stimulation-mediated negative inotropism and enhanced Na(+)/Ca(2+) exchange in mouse ventricle

1 reference

12 December 2020

Epidemiology of heart failure

1 reference

12 December 2020

Opposing effects of alpha 1-adrenergic receptor subtypes on Ca2+ and pH homeostasis in rat cardiac myocytes

1 reference

12 December 2020

Beta-adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes

1 reference

12 December 2020

cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium

1 reference

12 December 2020

An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes

1 reference

12 December 2020

Preserved right ventricular ejection fraction predicts exercise capacity and survival in advanced heart failure

1 reference

12 December 2020

Right ventricular ejection fraction is an independent predictor of survival in patients with moderate heart failure

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12 December 2020

MYOCARDIAL NOREPINEPHRINE CONCENTRATION IN MAN. EFFECTS OF RESERPINE AND OF CONGESTIVE HEART FAILURE

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12 December 2020

Epidemiology of heart failure

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12 December 2020

Alpha(1)-adrenergic receptor subtype function in cardiomyocytes: lessons from genetic models in mice

1 reference

12 December 2020

Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure

1 reference

12 December 2020

Differential roles of cardiac myosin-binding protein C and cardiac troponin I in the myofibrillar force responses to protein kinase A phosphorylation

1 reference

12 December 2020

Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure

1 reference

12 December 2020

Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice

1 reference

12 December 2020

A study of the adrenotropic receptors

1 reference

12 December 2020

Inositol phosphate production following alpha 1-adrenergic, muscarinic or electrical stimulation in isolated rat heart

1 reference

12 December 2020

Sustained augmentation of cardiac alpha1A-adrenergic drive results in pathological remodeling with contractile dysfunction, progressive fibrosis and reactivation of matricellular protein genes

1 reference

12 December 2020

Turning off the signal: desensitization of beta-adrenergic receptor function

1 reference

12 December 2020

Comparison between alpha-1 adrenoceptor-mediated and beta adrenoceptor-mediated inotropic components elicited by norepinephrine in failing human ventricular muscle

1 reference

12 December 2020

Alpha 1-adrenoceptor-mediated phosphoinositide breakdown and inotropic response in rat left ventricular papillary muscles

1 reference

12 December 2020

Transgenic incorporation of skeletal TnT into cardiac myofilaments blunts PKC-mediated depression of force

1 reference

12 December 2020

Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity

1 reference

12 December 2020

Overexpression of alpha1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy

1 reference

12 December 2020

CATECHOLAMINE EXCRETION AND CARDIAC STORES OF NOREPINEPHRINE IN CONGESTIVE HEART FAILURE

1 reference

12 December 2020

Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure

1 reference

12 December 2020

Crosstalk between alpha-1A and alpha-1B adrenoceptors in neonatal rat myocardium: implications in cardiac hypertrophy

1 reference

12 December 2020

10.1007/S00424-014-1491-5

Identifiers

DOI

1 reference

Dimensions Publication ID

30 August 2017

1006856580

0 references

1 reference