(Q38200876)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24686413%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24686413%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24686413%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Chris J Paddon

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24686413%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

language of work or name

English

0 references

publication date

1 April 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24686413%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Microbiology

12 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24686413%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24686413%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24686413%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

page(s)

355-367

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24686413%20AND%20SRC:MED&resulttype=core&format=json

Untersuchungen über die wasserfreien organischen Säuren

12 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Qinghaosu (Artemisinin): The Price of Success

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Reflections on the 'discovery' of the antimalarial qinghao

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Qinghaosu (artemisinin): an antimalarial drug from China

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Discovery, mechanisms of action and combination therapy of artemisinin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

A major genome region underlying artemisinin resistance in malaria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Artemisinin resistance: current status and scenarios for containment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Artemisinin-resistant malaria: research challenges, opportunities, and public health implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Stabilizing supply of artemisinin and artemisinin-based combination therapy in an era of wide-spread scale-up

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Functional genomics and the biosynthesis of artemisinin.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Methylerythritol phosphate pathway of isoprenoid biosynthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Mono and diterpene production in Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

The in vivo synthesis of plant sesquiterpenes by Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically engineered Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Microbial sensors for small molecules: development of a mevalonate biosensor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Application of functional genomics to pathway optimization for increased isoprenoid production.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Production of mevalonate by a metabolically-engineered Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Class II 3-hydroxy-3-methylglutaryl coenzyme A reductases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

A simple conversion of artemisinic acid into artemisinin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Four linked genes participate in controlling sporulation efficiency in budding yeast

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

An interlaboratory comparison of physiological and genetic properties of four Saccharomyces cerevisiae strains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

High-level semi-synthetic production of the potent antimalarial artemisinin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Mechanisms that regulate production of reactive oxygen species by cytochrome P450.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

The many roles of cytochrome b5

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Microbial production of plant benzylisoquinoline alkaloids

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Recent progress in the metabolic engineering of alkaloids in plant systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

A bacterial platform for fermentative production of plant alkaloids

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Programming cells by multiplex genome engineering and accelerated evolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Yeast oligo-mediated genome engineering (YOGE).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Plasmid construction by homologous recombination in yeast.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Recombination-mediated PCR-directed plasmid construction in vivo in yeast

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

A versatile, efficient strategy for assembly of multi-fragment expression vectors in Saccharomyces cerevisiae using 60 bp synthetic recombination sequences.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Chain reaction cloning: a one-step method for directional ligation of multiple DNA fragments

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Circular polymerase extension cloning of complex gene libraries and pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Enzymatic assembly of DNA molecules up to several hundred kilobases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Rapid and reliable DNA assembly via ligase cycling reaction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Automated assembly of standard biological parts.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Synergies between synthetic biology and metabolic engineering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Toward a science of metabolic engineering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Metabolic engineering: past and future

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Metabolic engineering for the microbial production of 1,3-propanediol

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

DeviceEditor visual biological CAD canvas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

j5 DNA assembly design automation software

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Design, implementation and practice of JBEI-ICE: an open source biological part registry platform and tools

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

PaR-PaR laboratory automation platform

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Quantitative estimation of activity and quality for collections of functional genetic elements

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Foundations for engineering biology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Synthetic biology: from hype to impact

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Synthetic biology: new engineering rules for an emerging discipline

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Synthetic biology and metabolic engineering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Construction of a genetic toggle switch in Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

A synthetic oscillatory network of transcriptional regulators

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Precise and reliable gene expression via standard transcription and translation initiation elements

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Rewritable digital data storage in live cells via engineered control of recombination directionality

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Amplifying genetic logic gates

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Biosynthesis of isoprenoids via the non-mevalonate pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Distribution of mevalonate and glyceraldehyde 3-phosphate/pyruvate routes for isoprenoid biosynthesis in some gram-negative bacteria and mycobacteria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

THE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE PATHWAY OF ISOPRENOID BIOSYNTHESIS IN PLANTS

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Heterologous expression and characterization of bacterial 2-C-methyl-D-erythritol-4-phosphate pathway in Saccharomyces cerevisiae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Maturation of iron-sulfur proteins in eukaryotes: mechanisms, connected processes, and diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Production of plant sesquiterpenes in Saccharomyces cerevisiae: effect of ERG9 repression on sesquiterpene biosynthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

The metabolite chemotype of Nicotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP71AV1 type and relative gene dosage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3240

Microbially derived artemisinin: a biotechnology solution to the global problem of access to affordable antimalarial drugs

31 March 2020

1 reference

12 December 2020

Temperature dependence of cytochrome P-450 reduction. A model for NADPH-cytochrome P-450 reductase:cytochrome P-450 interaction

1 reference

12 December 2020

Genealogy of principal strains of the yeast genetic stock center

1 reference

12 December 2020

Antimalaria studies on Qinghaosu

1 reference

12 December 2020

How Chinese scientists discovered qinghaosu (artemisinin) and developed its derivatives? What are the future perspectives?

1 reference

12 December 2020

Roles of key active-site residues in flavocytochrome P450 BM3

1 reference

12 December 2020