(Q38203784)

30 August 2017

title

FOXP3 and scurfy: how it all began (English)

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30 August 2017

Fred Ramsdell

1

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30 August 2017

Steven F Ziegler

series ordinal

2

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30 August 2017

publication date

11 April 2014

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Nature Reviews Immunology

30 August 2017

published in

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30 August 2017

volume

14

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30 August 2017

issue

5

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30 August 2017

page(s)

343-349

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Radiation dose rate and mutation frequency.

30 August 2017

cites work

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EXCEPTIONAL INHERITANCE OF A SEX-LINKED GENE IN THE MOUSE EXPLAINED ON THE BASIS THAT THE X/O SEX-CHROMOSOME CONSTITUTION IS FEMALE

21 January 2018

1 reference

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education

21 January 2018

1 reference

Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes

21 January 2018

1 reference

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

1 reference

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

1 reference

The amount of scurfin protein determines peripheral T cell number and responsiveness

21 January 2018

1 reference

Regulatory T cells in autoimmmunity*.

21 January 2018

1 reference

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

1 reference

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

21 January 2018

1 reference

An essential role for Scurfin in CD4+CD25+ T regulatory cells

21 January 2018

1 reference

Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

1 reference

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy.

21 January 2018

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

21 January 2018

1 reference

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

21 January 2018

1 reference

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

21 January 2018

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Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

21 January 2018

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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

21 January 2018

1 reference

Natural versus adaptive regulatory T cells

21 January 2018

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Peripherally induced tregs - role in immune homeostasis and autoimmunity

21 January 2018

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Antigen-specific peripheral shaping of the natural regulatory T cell population

21 January 2018

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TCR repertoire and Foxp3 expression define functionally distinct subsets of CD4+ regulatory T cells

21 January 2018

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Stability of the regulatory T cell lineage in vivo.

21 January 2018

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Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

21 January 2018

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The plasticity and stability of regulatory T cells.

21 January 2018

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Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation

21 January 2018

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Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor

21 January 2018

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FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease.

21 January 2018

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FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

21 January 2018

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Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells

21 January 2018

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Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3

21 January 2018

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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

21 January 2018

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Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

21 January 2018

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Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells

21 January 2018

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Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

21 January 2018

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Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells

21 January 2018

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FOXP3 controls regulatory T cell function through cooperation with NFAT

21 January 2018

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Transcription factor Foxp3 and its protein partners form a complex regulatory network

21 January 2018

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Foxp3 occupancy and regulation of key target genes during T-cell stimulation

21 January 2018

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Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

21 January 2018

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Molecular mechanisms underlying FOXP3 induction in human T cells

21 January 2018

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IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

21 January 2018

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CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation.

21 January 2018

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DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.

21 January 2018

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Epigenetic control of the foxp3 locus in regulatory T cells

21 January 2018

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DNA methylation controls Foxp3 gene expression

21 January 2018

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Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome

21 January 2018

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Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

21 January 2018

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c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells.

21 January 2018

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c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

21 January 2018

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

21 January 2018

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Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

21 January 2018

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Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells

21 January 2018

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Extrathymically generated regulatory T cells control mucosal TH2 inflammation

21 January 2018

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Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict

21 January 2018

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De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells

21 January 2018

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Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

21 January 2018

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Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

21 January 2018

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The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.

21 January 2018

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Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28

21 January 2018

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JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome

21 January 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

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Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

21 January 2018

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Regulatory T cell development in the absence of functional Foxp3.

21 January 2018

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Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

21 January 2018

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IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

21 January 2018

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Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells

21 January 2018

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Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells

21 January 2018

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Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

21 January 2018

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Foxp3-dependent programme of regulatory T-cell differentiation

21 January 2018

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X-ray-induced mutations in mice

21 January 2018

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Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

31 March 2020

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c-Rel but not NF-κB1 is important for T regulatory cell development

31 March 2020

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Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation

31 March 2020

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Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

31 March 2020

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Transplantation of T cell-mediated, lymphoreticular disease from the scurfy (sf) mouse.

31 March 2020

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12 December 2020

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse

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12 December 2020

The murine mutation scurfy (sf) results in an antigen-dependent lymphoproliferative disease with altered T cell sensitivity

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12 December 2020

CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse

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12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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12 December 2020

Identifiers

DOI

10.1038/NRI3650

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Dimensions Publication ID

30 August 2017

1027365885

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