(Q38205932)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24750474%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases (English)

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14 March 2020

1

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14 March 2020

Paula I Rodas

3

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14 March 2020

Luis Velasquez

5

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14 March 2020

author name string

Juan P Peñaloza

2

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14 March 2020

Ricardo Fernández-Ramires

4

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14 March 2020

Juan E Jung

6

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14 March 2020

publication date

12 May 2014

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Fundamental and Clinical Pharmacology

14 March 2020

published in

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14 March 2020

volume

28

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14 March 2020

page(s)

593-607

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14 March 2020

issue

6

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Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

14 March 2020

cites work

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Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes

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PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

21 January 2018

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Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.

21 January 2018

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Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors

21 January 2018

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Compartmentalization of cyclic nucleotide signaling: a question of when, where, and why?

21 January 2018

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Drugs and their molecular targets: an updated overview

21 January 2018

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Cyclic nucleotide research -- still expanding after half a century

21 January 2018

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21 January 2018

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Phosphodiesterases and cyclic nucleotide signaling in endocrine cells

21 January 2018

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Historical review: a brief history and personal retrospective of seven-transmembrane receptors

21 January 2018

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

21 January 2018

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Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes

21 January 2018

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Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

21 January 2018

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21 January 2018

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Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function

21 January 2018

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Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes

21 January 2018

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Recombinant expression of a type IV, cAMP-specific phosphodiesterase: characterization and structure-function studies of deletion mutants.

21 January 2018

1 reference

Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinase

21 January 2018

1 reference

Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system

21 January 2018

1 reference

The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases

21 January 2018

1 reference

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting

21 January 2018

1 reference

AKAP signaling complexes: getting to the heart of the matter

21 January 2018

1 reference

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

21 January 2018

1 reference

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

21 January 2018

1 reference

Epac: a new cAMP target and new avenues in cAMP research

21 January 2018

1 reference

Components of a new human protein kinase signal transduction pathway

21 January 2018

1 reference

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

21 January 2018

1 reference

Cyclic 3',5'-nucleotide phosphodiesterase. Demonstration of an activator.

21 January 2018

1 reference

Electron microscopic immunocytochemical evidence that the calmodulin-dependent cyclic nucleotide phosphodiesterase is localized predominantly at postsynaptic sites in the rat brain

21 January 2018

1 reference

Cyclic nucleotide phosphodiesterases

21 January 2018

1 reference

Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis

21 January 2018

1 reference

Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm

21 January 2018

1 reference

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

21 January 2018

1 reference

A novel cyclic GMP stimulated phosphodiesterase from rat brain

21 January 2018

1 reference

Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression

21 January 2018

1 reference

Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation

21 January 2018

1 reference

A phosphodiesterase 2A isoform localized to mitochondria regulates respiration

21 January 2018

1 reference

Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family

21 January 2018

1 reference

Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart

21 January 2018

1 reference

Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group

21 January 2018

1 reference

Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice

21 January 2018

1 reference

From PDE3B to the regulation of energy homeostasis

21 January 2018

1 reference

Phosphatidic acid induces ligand-independent epidermal growth factor receptor endocytic traffic through PDE4 activation

21 January 2018

1 reference

PDE4 as a target for cognition enhancement

21 January 2018

1 reference

Role of multiple cAMP-specific phosphodiesterase variants

21 January 2018

1 reference

Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase

21 January 2018

1 reference

Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area

21 January 2018

1 reference

Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases.

21 January 2018

1 reference

Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum

21 January 2018

1 reference

Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase

21 January 2018

1 reference

Expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in mouse tissues and cell lines using an antibody against the enzyme amino-terminal domain.

21 January 2018

1 reference

Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5).

21 January 2018

1 reference

Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene

21 January 2018

1 reference

An update on new oral PDE5 inhibitors for the treatment of erectile dysfunction

21 January 2018

1 reference

Sildenafil citrate therapy for pulmonary arterial hypertension

21 January 2018

1 reference

Cyclic GMP phosphodiesterases and regulation of smooth muscle function

21 January 2018

1 reference

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

21 January 2018

1 reference

cGMP phosphodiesterase of retinal rods is regulated by two inhibitory subunits

21 January 2018

1 reference

Heterozygous missense mutation in the rod cGMP phosphodiesterase beta-subunit gene in autosomal dominant stationary night blindness

21 January 2018

1 reference

Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa

21 January 2018

1 reference

Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart

21 January 2018

1 reference

Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants

21 January 2018

1 reference

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

21 January 2018

1 reference

Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.

21 January 2018

1 reference

T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3

21 January 2018

1 reference

Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors

21 January 2018

1 reference

Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase

21 January 2018

1 reference

Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase

21 January 2018

1 reference

PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER.

21 January 2018

1 reference

Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes

21 January 2018

1 reference

Mutation in PDE8B, a cyclic AMP-specific phosphodiesterase in adrenal hyperplasia

21 January 2018

1 reference

Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene

21 January 2018

1 reference

Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase

21 January 2018

1 reference

Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants

21 January 2018

1 reference

cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11

21 January 2018

1 reference

Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia

21 January 2018

1 reference

Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype

21 January 2018

1 reference

Phosphodiesterase 11A (PDE11A) gene defects in patients with acth-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors

21 January 2018

1 reference

Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions

21 January 2018

1 reference

Overview of PDEs and their regulation

21 January 2018

1 reference

Layers of organization of cAMP microdomains in a simple cell

21 January 2018

1 reference

Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes

21 January 2018

1 reference

Real-time monitoring of phosphodiesterase inhibition in intact cells.

21 January 2018

1 reference

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

21 January 2018

1 reference

Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathy

21 January 2018

1 reference

Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart

21 January 2018

1 reference

cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology

21 January 2018

1 reference

cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling

21 January 2018

1 reference

cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.

21 January 2018

1 reference

Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals

21 January 2018

1 reference

Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes

21 January 2018

1 reference

Growth factors in glomerulonephritis

21 January 2018

1 reference

The mesangial cell revisited: no cell is an island

21 January 2018

1 reference

Differential regulation of mesangial cell mitogenesis by cAMP phosphodiesterase isozymes 3 and 4.

21 January 2018

1 reference

Mechanism of inhibition of Raf-1 by protein kinase A.

21 January 2018

1 reference

Increasing cAMP attenuates activation of mitogen-activated protein kinase

21 January 2018

1 reference

Role of reactive oxygen species in glomerulonephritis

21 January 2018

1 reference

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness

21 January 2018

1 reference

cGMP Signaling, Phosphodiesterases and Major Depressive Disorder

21 January 2018

1 reference

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

21 January 2018

1 reference

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

21 January 2018

1 reference

Role of DISC1 in neural development and schizophrenia

21 January 2018

1 reference

DISC1 genetics, biology and psychiatric illness

21 January 2018

1 reference

Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases

21 January 2018

1 reference

Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals

21 January 2018

1 reference

Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain

21 January 2018

1 reference

Two domains are critical for the nuclear localization of soluble adenylyl cyclase

21 January 2018

1 reference

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

21 January 2018

1 reference

Estimating the world cancer burden: Globocan 2000.

21 January 2018

1 reference

Bacterial enterotoxins are associated with resistance to colon cancer.

21 January 2018

1 reference

Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology

21 January 2018

1 reference

Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.

21 January 2018

1 reference

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

21 January 2018

1 reference

Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen

21 January 2018

1 reference

Can β2-adrenoceptor agonists, anticholinergic drugs, and theophylline contribute to the control of pulmonary inflammation and emphysema in COPD?

21 January 2018

1 reference

Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

21 January 2018

1 reference

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

21 January 2018

1 reference

cAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse

21 January 2018

1 reference

New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors

21 January 2018

1 reference

Protection from apoptotic cell death by cilostazol, phosphodiesterase type III inhibitor, via cAMP-dependent protein kinase activation

21 January 2018

1 reference

Targeting cancer with phosphodiesterase inhibitors

21 January 2018

1 reference

Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases.

21 January 2018

1 reference

Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A).

21 January 2018

1 reference

Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation

21 January 2018

1 reference

Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases

21 January 2018

1 reference

The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner.

21 January 2018

1 reference

Interaction of calcium antagonists with cyclic AMP phosphodiesterases and calmodulin

21 January 2018

1 reference

Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle

21 January 2018

1 reference

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

21 January 2018

1 reference

Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor

21 January 2018

1 reference

Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase

21 January 2018

1 reference

Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine

21 January 2018

1 reference

Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance

21 January 2018

1 reference

Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability

21 January 2018

1 reference

cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles

21 January 2018

1 reference

A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway

21 January 2018

1 reference

A cGMP-signaling pathway in a subset of olfactory sensory neurons

21 January 2018

1 reference

Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase

21 January 2018

1 reference

HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro

21 January 2018

1 reference

Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity

21 January 2018

1 reference

Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D.

21 January 2018

1 reference

Heterologous expression and purification of recombinant rolipram-sensitive cyclic AMP-specific phosphodiesterases

21 January 2018

1 reference

Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene

21 January 2018

1 reference

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

21 January 2018

1 reference

The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways

21 January 2018

1 reference

Synthesis and profile of SCH351591, a novel PDE4 inhibitor.

21 January 2018

1 reference

Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers

21 January 2018

1 reference

Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity

21 January 2018

1 reference

On-demand IC351 (Cialis) enhances erectile function in patients with erectile dysfunction

21 January 2018

1 reference

Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5

21 January 2018

1 reference

Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase

21 January 2018

1 reference

Identification of human PDE7B, a cAMP-specific phosphodiesterase

21 January 2018

1 reference

Crystal structure of phosphodiesterase 4D and inhibitor complex(1)

21 January 2018

1 reference

PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.

21 January 2018

1 reference

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.

21 January 2018

1 reference

Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans

21 January 2018

1 reference

Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene

21 January 2018

1 reference

Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases

21 January 2018

1 reference

Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase

21 January 2018

1 reference

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive funct

21 January 2018

1 reference

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

21 January 2018

1 reference

Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP.

21 January 2018

1 reference

Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine

21 January 2018

1 reference

Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants

21 January 2018

1 reference

Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen

21 January 2018

1 reference

Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes

21 January 2018

1 reference

Hard Times for Oncogenic BRAF-Expressing Melanoma Cells

21 January 2018

1 reference