(Q38217069)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Targeting mucus hypersecretion: new therapeutic opportunities for COPD? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Justine Frija-Masson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Pierre Regis Burgel

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

author name string

Clémence Martin

1

1 reference

31 August 2017

Justine Frija-Masson

2

1 reference

31 August 2017

Pierre-Régis Burgel

3

1 reference

31 August 2017

1 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

volume

74

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

page(s)

1073-1089

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24890395%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s40265-014-0235-3

19 March 2020

exact match

0 references

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.

21 January 2018

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IL-6 is required for airway mucus production induced by inhaled fungal allergens

21 January 2018

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Induction of mucin and MUC5AC expression by the protease activity of Aspergillus fumigatus in airway epithelial cells

21 January 2018

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Neutrophil elastase induces mucus cell metaplasia in mouse lung.

21 January 2018

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Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo.

21 January 2018

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Differential regulation of airway mucin gene expression and mucin secretion by extracellular nucleotide triphosphates

21 January 2018

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MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium

21 January 2018

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Epidermal growth factor system regulates mucin production in airways

21 January 2018

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Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium

21 January 2018

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Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases.

21 January 2018

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Foxa2 regulates alveolarization and goblet cell hyperplasia.

21 January 2018

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IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production

21 January 2018

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SPDEF regulates goblet cell hyperplasia in the airway epithelium

21 January 2018

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Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents.

21 January 2018

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Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme

21 January 2018

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https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells

21 January 2018

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Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium

21 January 2018

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CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells

21 January 2018

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Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells

21 January 2018

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Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells

21 January 2018

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Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD.

21 January 2018

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Goblet cell degranulation after antigen challenge in sensitized guinea pigs. Role of neutrophils

21 January 2018

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Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation

21 January 2018

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Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma

21 January 2018

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Predictors of objective cough frequency in chronic obstructive pulmonary disease.

21 January 2018

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New molecular targets for the treatment of neutrophilic diseases

21 January 2018

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Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease.

21 January 2018

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Effect of dexamethasone and ACC on bacteria-induced mucin expression in human airway mucosa

21 January 2018

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Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK.

21 January 2018

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Dexamethasone and N-acetyl-cysteine attenuate Pseudomonas aeruginosa-induced mucus expression in human airways.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Glucocorticoids inhibit MUC5AC production induced by transforming growth factor-α in human respiratory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Intranasal steroids decrease eosinophils but not mucin expression in nasal polyps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Corticosteroid therapy increases membrane-tethered while decreases secreted mucin expression in nasal polyps.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Mucoactive therapy in COPD.

21 January 2018

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Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial

21 January 2018

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High-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE study

21 January 2018

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Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study

21 January 2018

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N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

L-carbocisteine reduces neutrophil elastase-induced mucin production.

21 January 2018

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Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils

21 January 2018

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Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide

21 January 2018

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Respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of N-acetylcysteine

21 January 2018

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Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary

21 January 2018

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A 4-year trial of tiotropium in chronic obstructive pulmonary disease

21 January 2018

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Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice

21 January 2018

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Phosphodiesterase-4 inhibitor therapy for lung diseases

21 January 2018

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Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells.

21 January 2018

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Phosphodiesterase 4 inhibitors for the treatment of COPD.

21 January 2018

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Azithromycin for prevention of exacerbations of COPD.

21 January 2018

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Long-term macrolide treatment for chronic respiratory disease.

21 January 2018

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Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 Cells

21 January 2018

1 reference

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Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells

21 January 2018

1 reference

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Azithromycin inhibits nontypeable Haemophilus influenzae-induced MUC5AC expression and secretion via inhibition of activator protein-1 in human airway epithelial cells

21 January 2018

1 reference

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Macrolides inhibit Fusobacterium nucleatum-induced MUC5AC production in human airway epithelial cells.

21 January 2018

1 reference

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Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Macrolides attenuate mucus hypersecretion in rat airways through inactivation of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

First-line management of EGFR-mutated advanced lung adenocarcinoma: recent developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells

21 January 2018

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Long-term safety study of infliximab in moderate-to-severe chronic obstructive pulmonary disease.

21 January 2018

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Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation

21 January 2018

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Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates acrolein-induced airway mucus hypersecretion in rats.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Pharmacological actions of statins: potential utility in COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Blocking of thromboxane A₂ receptor attenuates airway mucus hyperproduction induced by cigarette smoke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1.

21 January 2018

1 reference

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MUC5AC mucin release from human airways in vitro: effects of indomethacin and Bay X1005

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Arginase inhibition prevents inflammation and remodeling in a guinea pig model of chronic obstructive pulmonary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions.

21 January 2018

1 reference

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Lung protease/anti-protease network and modulation of mucus production and surfactant activity.

21 January 2018

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21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Calpain and MARCKS protein regulation of airway mucin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Induced sputum concentrations of mucin in patients with asthma and chronic cough

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Update on the roles of distal airways in COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-kappaB-mediated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Goblet cells secretion and mucogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Roflumilast inhibits respiratory syncytial virus infection in human differentiated bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-014-0235-3

Role of the parasympathetic system in airway obstruction due to emphysema

21 January 2018

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12 December 2020

Chronic cough in chronic obstructive pulmonary disease: time for listening?

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12 December 2020

The chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study

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12 December 2020

Neutrophil-dependent goblet cell degranulation: role of membrane-bound elastase and adhesion molecules.

1 reference

12 December 2020

Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways

1 reference

12 December 2020

Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation

1 reference

12 December 2020

Muc5b is required for airway defence

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12 December 2020

Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells.

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12 December 2020

Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways

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12 December 2020

Morphologic and morphometric effects of prolonged cigarette smoking on the small airways

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12 December 2020

Sildenafil: a definitive NO in COPD

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12 December 2020

Regulated mucin secretion from airway epithelial cells

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12 December 2020

Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis

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12 December 2020

Chronic cough and sputum production: a clinical COPD phenotype?

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12 December 2020

Azithromycin inhibits mucus hypersecretion from airway epithelial cells

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12 December 2020

The National Institutes of Health Intermittent Positive-Pressure Breathing trial: pathology studies. II. Correlation between morphologic findings, clinical findings, and evidence of expiratory air-flow obstruction

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12 December 2020

Acrolein-induced MUC5ac expression in rat airways.

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12 December 2020

Pathologic changes in the peripheral airways of young cigarette smokers

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12 December 2020

SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

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12 December 2020

Biochemistry. Walking on solid ground

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12 December 2020

Macrolide antibiotics inhibit mucus secretion and calcium entry in Swine airway submucosal mucous gland cells

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12 December 2020

Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways

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12 December 2020

Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke

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12 December 2020

Chronic bronchitis in COPD patients is associated with increased risk of exacerbations: a cross-sectional multicentre study

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12 December 2020

Simvastatin attenuates lipopolysaccharide-induced airway mucus hypersecretion in rats

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12 December 2020

Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease

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12 December 2020

Inflammatory cells in the bronchial glands of smokers with chronic bronchitis

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12 December 2020

Reassessment of inflammation of airways in chronic bronchitis

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12 December 2020

IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells

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12 December 2020

Classical second messengers are not involved in proteinase-induced degranulation of airway gland cells.

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12 December 2020

Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations

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12 December 2020

Mucus hypersecretion in COPD: should we only rely on symptoms?

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12 December 2020