(Q38217505)

31 August 2017

title

Monoamine oxidase A and B substrates: probing the pathway for drug development (English)

1 reference

31 August 2017

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24895896%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Sarah Chajkowski-Scarry

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24895896%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

1 April 2014

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Future Medicinal Chemistry

31 August 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24895896%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24895896%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24895896%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

697-717

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24895896%20AND%20SRC:MED&resulttype=core&format=json

Transcriptional regulation and multiple functions of MAO genes

6 June 2020

cites work

1 reference

Renalase is an α-NAD(P)H oxidase/anomerase

21 January 2018

1 reference

21 January 2018

The human flavoproteome

1 reference

²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme

21 January 2018

1 reference

Expression of zebrafish (Danio rerio) monoamine oxidase (MAO) in Pichia pastoris: purification and comparison with human MAO A and MAO B.

21 January 2018

1 reference

Structural properties of human monoamine oxidases A and B

21 January 2018

1 reference

Monoamine oxidase inhibitors: ten years of docking studies

21 January 2018

1 reference

Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening

21 January 2018

1 reference

Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases

21 January 2018

1 reference

Functional role of the "aromatic cage" in human monoamine oxidase B: structures and catalytic properties of Tyr435 mutant proteins.

21 January 2018

1 reference

Computational Study of the pKa Values of Potential Catalytic Residues in the Active Site of Monoamine Oxidase B.

21 January 2018

1 reference

Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B

21 January 2018

1 reference

Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders

21 January 2018

1 reference

Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures

21 January 2018

1 reference

The ‘gating’ residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition

21 January 2018

1 reference

Potentiation of Ligand Binding through Cooperative Effects in Monoamine Oxidase B

21 January 2018

1 reference

On the formation and nature of the imidazoline I2 binding site on human monoamine oxidase-B.

21 January 2018

1 reference

Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors

21 January 2018

1 reference

Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B

21 January 2018

1 reference

Development of spin-labeled pargyline analogues as specific inhibitors of human monoamine oxidases A and B.

21 January 2018

1 reference

Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis

21 January 2018

1 reference

Comparison of the structural properties of the active site cavities of human and rat monoamine oxidase A and B in their soluble and membrane-bound forms

21 January 2018

1 reference

Impact of species-dependent differences on screening, design, and development of MAO B inhibitors

21 January 2018

1 reference

Hyperserotonergic phenotype after monoamine oxidase inhibition in larval zebrafish

21 January 2018

1 reference

Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): comparisons with human MAO A and MAO B

21 January 2018

1 reference

Kinetic behavior and reversible inhibition of monoamine oxidases--enzymes that many want dead

21 January 2018

1 reference

Reactions and enzymes in the metabolism of drugs and other xenobiotics

21 January 2018

1 reference

FAD-dependent enzymes involved in the metabolic oxidation of xenobiotics

21 January 2018

1 reference

Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study

21 January 2018

1 reference

In vitro-in vivo correlation for intrinsic clearance for CP-409,092 and sumatriptan: a case study to predict the in vivo clearance for compounds metabolized by monoamine oxidase.

21 January 2018

1 reference

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.

21 January 2018

1 reference

The MPTP/probenecid model of progressive Parkinson's disease

21 January 2018

1 reference

Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors

21 January 2018

1 reference

Role of cyclic tertiary amine bioactivation to reactive iminium species: structure toxicity relationship

21 January 2018

1 reference

A novel and selective monoamine oxidase B substrate.

21 January 2018

1 reference

Stereochemical studies on the novel monoamine oxidase B substrates (1R,6S)- and (1S,6R)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane

21 January 2018

1 reference

Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B.

21 January 2018

1 reference

Pharmacokinetics, disposition, and metabolism of bicifadine in the mouse, rat, and monkey

21 January 2018

1 reference

Pharmacokinetics, disposition, and metabolism of bicifadine in humans

21 January 2018

1 reference

6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor

21 January 2018

1 reference

The potential and limitations of DOV 216,303 as a triple reuptake inhibitor for the treatment of major depression: a microdialysis study in olfactory bulbectomized rats

21 January 2018

1 reference

Do MAO A and MAO B utilize the same mechanism for the C-H bond cleavage step in catalysis? Evidence suggesting differing mechanisms

21 January 2018

1 reference

Oxidation of amines by flavoproteins

21 January 2018

1 reference

Structures and Mechanism of the Monoamine Oxidase Family

21 January 2018

1 reference

Monoamine oxidases: the biochemistry of the proteins as targets in medicinal chemistry and drug discovery

21 January 2018

1 reference

Computational investigation on the structure-activity relationship of the biradical mechanism for monoamine oxidase

21 January 2018

1 reference

Reaction of benzophenone triplet with aliphatic amines. What a potent neurotoxin can tell us about the reaction mechanism

21 January 2018

1 reference

An overview of phenylcyclopropylamine derivatives: biochemical and biological significance and recent developments

21 January 2018

1 reference

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

21 January 2018

1 reference

Crystallographic snapshots of the complete reaction cycle of nicotine degradation by an amine oxidase of the monoamine oxidase (MAO) family

21 January 2018

1 reference

Computational modeling of the direct hydride transfer mechanism for the MAO catalyzed oxidation of phenethylamine and benzylamine: ONIOM (QM/QM) calculations.

21 January 2018

1 reference

Current place of monoamine oxidase inhibitors in the treatment of depression

21 January 2018

1 reference

Monoamine oxidase-B (MAO-B) inhibitors: implications for disease-modification in Parkinson's disease

21 January 2018

1 reference

Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury

21 January 2018

1 reference

From depression to neurodegeneration and heart failure: re-examining the potential of MAO inhibitors

21 January 2018

1 reference

Targeting monoamine oxidase A in advanced prostate cancer

21 January 2018

1 reference

21 January 2018

1 reference

Parkinson's disease management. Part II- discovery of MAO-B inhibitors based on nitrogen heterocycles and analogues

21 January 2018

1 reference

Discovery and optimization of pyrazoline derivatives as promising monoamine oxidase inhibitors

21 January 2018

1 reference

Discovery of MAO-B inhibitors - present status and future directions part I: oxygen heterocycles and analogs

21 January 2018

1 reference

A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.

21 January 2018

1 reference

Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis

21 January 2018

1 reference

Quantum-chemical approach to determining the high potency of clorgyline as an irreversible acetylenic monoamine oxidase inhibitor.

21 January 2018

1 reference

An update on amine oxidase inhibitors: multifaceted drugs

21 January 2018

1 reference

Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

21 January 2018

1 reference

Rasagiline prevents apoptosis induced by PK11195, a ligand of the outer membrane translocator protein (18 kDa), in SH-SY5Y cells through suppression of cytochrome c release from mitochondria

21 January 2018

1 reference

I1 imidazoline receptor: novel potential cytoprotective target of TVP1022, the S-enantiomer of rasagiline

21 January 2018

1 reference

Propargylamine-derived multitarget-directed ligands: fighting Alzheimer's disease with monoamine oxidase inhibitors

21 January 2018

1 reference

The emergence of designed multiple ligands for neurodegenerative disorders

21 January 2018

1 reference

Rationally designed multi-targeted agents against neurodegenerative diseases

21 January 2018

1 reference

Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline

21 January 2018

1 reference

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of [...]

21 January 2018

1 reference

Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment

21 January 2018

1 reference

Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities

21 January 2018

1 reference

Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy

21 January 2018

1 reference

Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activities

21 January 2018

1 reference

A bioluminescent assay for monoamine oxidase activity

21 January 2018

1 reference

Activity-based fluorescent reporters for monoamine oxidases in living cells

21 January 2018

1 reference

Design of optical switches as metabolic indicators: new fluorogenic probes for monoamine oxidases (MAO A and B).

21 January 2018

1 reference

An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection.

21 January 2018

1 reference

Reaction-based two-photon probes for in vitro analysis and cellular imaging of monoamine oxidase activity

21 January 2018

1 reference

A direct continuous fluorometric turn-on assay for monoamine oxidase B and its inhibitor-screening based on the abnormal fluorescent behavior of silole

21 January 2018

1 reference

Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors

21 January 2018

1 reference

1H NMR probe for in situ monitoring of dopamine metabolism and its application to inhibitor screening.

21 January 2018

1 reference

Monoamine oxidase: radiotracer development and human studies

21 January 2018

1 reference

Radiochemistry devoted to the production of monoamine oxidase (MAO-A and MAO-B) ligands for brain imaging with positron emission tomography

21 January 2018

1 reference

Translational neuroimaging: positron emission tomography studies of monoamine oxidase.

21 January 2018

1 reference

Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline.

21 January 2018

1 reference

Species differences in [11C]clorgyline binding in brain.

21 January 2018

1 reference

Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors

21 January 2018

1 reference

Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C]harmine and [11C]raclopride

21 January 2018

1 reference

Radiosynthesis and in vivo evaluation of [11C]-labelled pyrrole-2-carboxamide derivates as novel radioligands for PET imaging of monoamine oxidase A.

21 January 2018

1 reference

In vivo quantification of monoamine oxidase A in baboon brain: a PET study using [(11)C]befloxatone and the multi-injection approach

21 January 2018

1 reference

[¹¹C]befloxatone brain kinetics is not influenced by Bcrp function at the blood-brain barrier: a PET study using Bcrp TGEM knockout rats

21 January 2018

1 reference

11C-harmine as a tracer for monoamine oxidase A (MAO-A): in vitro and in vivo studies

21 January 2018

1 reference

MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography

21 January 2018

1 reference

Mapping the cerebral monoamine oxidase type A: positron emission tomography characterization of the reversible selective inhibitor [11C]befloxatone

21 January 2018

1 reference

Synthesis and in vivo imaging properties of [11C]befloxatone: a novel highly potent positron emission tomography ligand for mono-amine oxidase-A.

21 January 2018

1 reference

Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study

21 January 2018

1 reference

Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG.

21 January 2018

1 reference

Evidence for astrocytosis in ALS demonstrated by [11C](L)-deprenyl-D2 PET.

21 January 2018

1 reference

Assessment of MAO-B occupancy in the brain with PET and [11C]-L-deprenyl-D2: a dose-finding study with a novel MAO-B inhibitor, EVT 301.

21 January 2018

1 reference

Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity

21 January 2018

1 reference

Synthesis of three novel fluorine-18 labeled analogues of L-deprenyl for positron emission tomography (PET) studies of monoamine oxidase B (MAO-B).

21 January 2018

1 reference

Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).

21 January 2018

1 reference

Development of a novel fluorine-18 labeled deuterated fluororasagiline ([(18)F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B).

21 January 2018

1 reference

Development of new radiopharmaceuticals for imaging monoamine oxidase B.

21 January 2018

1 reference

[(11)C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: preclinical characterisation in nonhuman primate

21 January 2018

1 reference

Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies

21 January 2018

1 reference

Enantioselective oxidation of C-O and C-N bonds using oxidases

21 January 2018

1 reference

The structure of monoamine oxidase from Aspergillus niger provides a molecular context for improvements in activity obtained by directed evolution

21 January 2018

1 reference

Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products

21 January 2018

1 reference

How are Biogenic Amines Metabolized by Monoamine Oxidases?

21 January 2018

1 reference

Irreversible Inhibition of Monoamine Oxidase B by the Antiparkinsonian Medicines Rasagiline and Selegiline: A Computational Study

21 January 2018

1 reference

Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions

21 January 2018

1 reference

Directed Evolution of the Enzyme Monoamine Oxidase (MAO-N): Highly Efficient Chemo-enzymatic Deracemisation of the Alkaloid (±)-Crispine A

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.14.23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24895896%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference