(Q38224544)

31 August 2017

title

Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2. (English)

1 reference

31 August 2017

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977713%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Joana Moitinho Oliveira

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977713%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Rosa Gasa

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977713%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ramon Gomis

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977713%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

publication date

3 June 2014

1 reference

Canadian Journal of Physiology and Pharmacology

31 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977713%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

92

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977713%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977713%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

613-620

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24977713%20AND%20SRC:MED&resulttype=core&format=json

Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.

10 June 2020

cites work

1 reference

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The metabolisable hexoses D-glucose and D-mannose enhance the expression of IRS-2 but not of IRS-1 in pancreatic beta-cells

21 January 2018

1 reference

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Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation

21 January 2018

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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells

21 January 2018

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IRS proteins and beta-cell function

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes.

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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells

21 January 2018

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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

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Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.

21 January 2018

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Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice

21 January 2018

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Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

21 January 2018

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Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

21 January 2018

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Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms

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Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.

21 January 2018

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cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

21 January 2018

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

21 January 2018

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New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass

21 January 2018

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Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice

21 January 2018

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Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis

21 January 2018

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Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus

21 January 2018

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The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis

21 January 2018

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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

21 January 2018

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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells

21 January 2018

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Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes.

21 January 2018

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

21 January 2018

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Relationship between beta-cell mass and diabetes onset.

21 January 2018

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Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression.

21 January 2018

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Insulin signal transduction and the IRS proteins

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Tungstate promotes β-cell survival in Irs2-/- mice.

21 January 2018

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Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function

21 January 2018

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Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

21 January 2018

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Direct autocrine action of insulin on β-cells: does it make physiological sense?

21 January 2018

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Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus

21 January 2018

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Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

21 January 2018

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Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

21 January 2018

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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.

21 January 2018

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Global estimates of the prevalence of diabetes for 2010 and 2030

21 January 2018

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Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

21 January 2018

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The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.

21 January 2018

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Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance

21 January 2018

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Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance

21 January 2018

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

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Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

21 January 2018

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21 January 2018

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Beta cell apoptosis in diabetes

21 January 2018

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New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes

21 January 2018

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The IRS-signalling system: a network of docking proteins that mediate insulin action

21 January 2018

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Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

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Upregulation of insulin receptor substrate-2 in pancreatic β cells prevents diabetes

21 January 2018

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Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

21 January 2018

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