(Q38225581)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

Microsomal transfer protein (MTP) inhibition-a novel approach to the treatment of homozygous hypercholesterolemia (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

author name string

Cesare R Sirtori

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Stefano Bertolini

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

language of work or name

English

0 references

publication date

2 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

volume

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

page(s)

464-474

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24987866%20AND%20SRC:MED&resulttype=core&format=json

Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment

21 March 2020

cites work

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Recent advances in the treatment of homozygous familial hypercholesterolaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Homozygous familial hypercholesterolemia in Lebanon: a genotype/phenotype correlation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Effect of a splice site mutation in LDLR gene and two variations in PCSK9 gene in Tunisian families with familial hypercholesterolaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Severe hypercholesterolaemia: therapeutic goals and eligibility criteria for LDL apheresis in Europe

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Molecular mechanisms of autosomal recessive hypercholesterolemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Autosomal recessive hypercholesterolemia (ARH) and homozygous familial hypercholesterolemia (FH): a phenotypic comparison

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Autosomal recessive hypercholesterolaemia: long-term follow up and response to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

A combined LDL receptor/LDL receptor adaptor protein 1 mutation as the cause for severe familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Genetic and environmental factors affecting the response to statin therapy in patients with molecularly defined familial hypercholesterolaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Treatment of familial hypercholesterolemia: is there a need beyond statin therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Homozygous familial hypercholesterolemia and its management

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Microsomal triglyceride transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Multiple functions of microsomal triglyceride transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Identification of two classes of lipid molecule binding sites on the microsomal triglyceride transfer protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Loss of both phospholipid and triglyceride transfer activities of microsomal triglyceride transfer protein in abetalipoproteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Severe hypertriglyceridemia with pancreatitis: thirteen years' treatment with lomitapide.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Lomitapide: a review of its use in adults with homozygous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Common low-density lipoprotein receptor mutations in the French Canadian population

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Abnormal hepatic apolipoprotein B metabolism in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Rapid regression of atherosclerosis with MTP inhibitor treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Statin treatment in children with familial hypercholesterolemia: the younger, the better

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100

Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853890.2014.931100