(Q38232000)

31 August 2017

title

Oxidative DNA damage in disease--insights gained from base excision repair glycosylase-deficient mouse models (English)

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31 August 2017

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Harini Sampath

1

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31 August 2017

publication date

16 July 2014

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Environmental and Molecular Mutagenesis

31 August 2017

published in

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31 August 2017

volume

55

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31 August 2017

issue

9

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31 August 2017

page(s)

689-703

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Oxidative damage to DNA: relation to species metabolic rate and life span

31 August 2017

cites work

1 reference

Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

21 January 2018

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High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress.

21 January 2018

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The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA.

21 January 2018

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Manganese and its role in Parkinson's disease: from transport to neuropathology

21 January 2018

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Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III

21 January 2018

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Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction

21 January 2018

1 reference

Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer.

21 January 2018

1 reference

Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation

21 January 2018

1 reference

Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

21 January 2018

1 reference

hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs

21 January 2018

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Assessment of oxidative base damage to isolated and cellular DNA by HPLC-MS/MS measurement

21 January 2018

1 reference

Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice

21 January 2018

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The role of DNA repair in brain related disease pathology

21 January 2018

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Lack of the DNA repair enzyme OGG1 sensitizes dopamine neurons to manganese toxicity during development

21 January 2018

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The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis

21 January 2018

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Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.

21 January 2018

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Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours

21 January 2018

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Colorectal cancer and inherited mutations in base-excision repair

21 January 2018

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Cell cycle regulation of the murine 8-oxoguanine DNA glycosylase (mOGG1): mOGG1 associates with microtubules during interphase and mitosis

21 January 2018

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Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM.

21 January 2018

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Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.

21 January 2018

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Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice

21 January 2018

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Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1.

21 January 2018

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DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts

21 January 2018

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Mitochondrial DNA, base excision repair and neurodegeneration

21 January 2018

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Excision of products of oxidative DNA base damage by human NTH1 protein.

21 January 2018

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Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria.

21 January 2018

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Expression and polymorphisms of gene 8-oxoguanine glycosylase 1 and the level of oxidative DNA damage in peripheral blood lymphocytes of patients with Alzheimer's disease.

21 January 2018

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Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2

21 January 2018

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The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk

21 January 2018

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Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts.

21 January 2018

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Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphism

21 January 2018

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Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases

21 January 2018

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Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine

21 January 2018

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DNA glycosylase recognition and catalysis

21 January 2018

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Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders

21 January 2018

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DNA damage and ageing: new-age ideas for an age-old problem

21 January 2018

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Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2.

21 January 2018

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Reactive oxygen species and the central nervous system

21 January 2018

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Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis.

21 January 2018

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Aging and genome maintenance: lessons from the mouse?

21 January 2018

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Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

21 January 2018

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Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

21 January 2018

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Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes

21 January 2018

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Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts

21 January 2018

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Human DNA glycosylases involved in the repair of oxidatively damaged DNA.

21 January 2018

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Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain.

21 January 2018

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Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue

21 January 2018

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Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals

21 January 2018

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Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes

21 January 2018

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Non-linear accumulation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidized DNA damage, during aging

21 January 2018

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Base excision repair capacity in mitochondria and nuclei: tissue-specific variations

21 January 2018

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DNA damage induces down-regulation of PEPCK and G6P gene expression through degradation of PGC-1alpha

21 January 2018

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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

21 January 2018

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Ser 524 is a phosphorylation site in MUTYH and Ser 524 mutations alter 8-oxoguanine (OG): A mismatch recognition

21 January 2018

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Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers

21 January 2018

1 reference

8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice

21 January 2018

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Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice.

21 January 2018

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Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions.

21 January 2018

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The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo

21 January 2018

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Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage.

21 January 2018

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Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA.

21 January 2018

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Prevention of chronic experimental colitis induced by dextran sulphate sodium (DSS) in mice treated with FR91.

21 January 2018

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A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

21 January 2018

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Gene regulation and DNA damage in the ageing human brain

21 January 2018

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Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA

21 January 2018

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Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant

21 January 2018

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Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme

21 January 2018

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Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome

21 January 2018

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A short review on the implications of base excision repair pathway for neurons: relevance to neurodegenerative diseases

21 January 2018

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Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

21 January 2018

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DNA damage in normally and prematurely aged mice

21 January 2018

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Role of MUTYH in human cancer

21 January 2018

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The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

21 January 2018

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Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA

21 January 2018

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Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

21 January 2018

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Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA

21 January 2018

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Oxidative damage in nucleic acids and Parkinson's disease.

21 January 2018

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Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

21 January 2018

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The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions

21 January 2018

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Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA.

21 January 2018

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Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs

21 January 2018

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Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity.

21 January 2018

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Obesity and cancer: a gut microbial connection

21 January 2018

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Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

21 January 2018

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DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis.

21 January 2018

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Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.

21 January 2018

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hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type

21 January 2018

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21 January 2018

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DNA repair activity for oxidative damage and risk of lung cancer

21 January 2018

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Gender differences in steady-state levels of oxidative damage to DNA in healthy individuals

21 January 2018

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Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria

21 January 2018

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Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae

21 January 2018

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Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice

21 January 2018

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Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells.

21 January 2018

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The DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells.

21 January 2018

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Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress

21 January 2018

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Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains

21 January 2018

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The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death

21 January 2018

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Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases

21 January 2018

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Role of MUTYH and MSH2 in the control of oxidative DNA damage, genetic instability, and tumorigenesis.

21 January 2018

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Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice

21 January 2018

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Regulation of DNA glycosylases and their role in limiting disease

21 January 2018

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8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction

21 January 2018

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Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

21 January 2018

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Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain

21 January 2018

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8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

21 January 2018

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Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer

21 January 2018

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Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice

21 January 2018

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Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage

21 January 2018

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A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue

21 January 2018

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Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols

21 January 2018

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Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant

21 January 2018

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The Ser(326)Cys polymorphism of 8-oxoguanine glycosylase 1 (OGG1) is associated with type 2 diabetes in Mexican Americans

21 January 2018

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Inactivation of OGG1 increases the incidence of G . C-->T . A transversions in Saccharomyces cerevisiae: evidence for endogenous oxidative damage to DNA in eukaryotic cells.

21 January 2018

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Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse.

21 January 2018

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Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

21 January 2018

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A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA

21 January 2018

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Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine

21 January 2018

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The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

21 January 2018

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Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease.

21 January 2018

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Mitochondrial DNA damage level determines neural stem cell differentiation fate.

21 January 2018

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Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models

21 January 2018

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Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits.

21 January 2018

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Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors

21 January 2018

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Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population

21 January 2018

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Protection from palmitate-induced mitochondrial DNA damage prevents from mitochondrial oxidative stress, mitochondrial dysfunction, apoptosis, and impaired insulin signaling in rat L6 skeletal muscle cells

21 January 2018

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Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria

21 January 2018

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Balancing repair and tolerance of DNA damage caused by alkylating agents

21 January 2018

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7 January 2021

Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas

1 reference

7 January 2021

Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation

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7 January 2021

Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria

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7 January 2021

MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis

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7 January 2021

Microbial fingerprinting detects unique bacterial communities in the faecal microbiota of rats with experimentally-induced colitis

1 reference

7 January 2021

hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population

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7 January 2021

Identifiers

DOI

10.1002/EM.21886

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31 August 2017

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