(Q38240597)

31 August 2017

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The biology of Mur ligases as an antibacterial target (English)

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31 August 2017

Imène Kouidmi

1

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31 August 2017

Roger C Levesque

series ordinal

2

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31 August 2017

Catherine Paradis-Bleau

series ordinal

3

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31 August 2017

language of work or name

English

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publication date

5 September 2014

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31 August 2017

12

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based on heuristic

inferred from page(s)

published in

Molecular Microbiology

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31 August 2017

94

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31 August 2017

2

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31 August 2017

242-253

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Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusion.

31 August 2017

1 reference

Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis.

21 January 2018

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A MurF inhibitor that disrupts cell wall biosynthesis in Escherichia coli

21 January 2018

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MurF inhibitors with antibacterial activity: effect on muropeptide levels

21 January 2018

1 reference

Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli

21 January 2018

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Determination of the MurD mechanism through crystallographic analysis of enzyme complexes

21 January 2018

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"Open" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase

21 January 2018

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The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity

21 January 2018

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New targets and screening approaches in antimicrobial drug discovery

21 January 2018

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Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistance

21 January 2018

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A single amino acid substitution in the MurF UDP-MurNAc-pentapeptide synthetase renders Streptococcus pneumoniae dependent on CO2 and temperature

21 January 2018

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Distinct pathways for modification of the bacterial cell wall by non-canonical D-amino acids

21 January 2018

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An unusual mutation results in the replacement of diaminopimelate with lanthionine in the peptidoglycan of a mutant strain of Mycobacterium smegmatis

21 January 2018

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Control of cell morphogenesis in bacteria: two distinct ways to make a rod-shaped cell

21 January 2018

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Origins and evolution of antibiotic resistance

21 January 2018

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Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).

21 January 2018

1 reference

Multitarget ligands in antibacterial research: progress and opportunities

21 January 2018

1 reference

Structure and function of the Mur enzymes: development of novel inhibitors

21 January 2018

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Evaluation of the kinetic mechanism of Escherichia coli uridine diphosphate-N-acetylmuramate:L-alanine ligase.

21 January 2018

1 reference

Conditionally lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-gamma-glutamate ligases: identification of a ligase superfamily.

21 January 2018

1 reference

Phosphorylation of the Streptococcus pneumoniae cell wall biosynthesis enzyme MurC by a eukaryotic-like Ser/Thr kinase

21 January 2018

1 reference

The perpetual challenge of infectious diseases.

21 January 2018

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MreB and MurG as scaffolds for the cytoplasmic steps of peptidoglycan biosynthesis

21 January 2018

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The MurC ligase essential for peptidoglycan biosynthesis is regulated by the serine/threonine protein kinase PknA in Corynebacterium glutamicum

21 January 2018

1 reference

Functional analysis of the cytoskeleton protein MreB from Chlamydophila pneumoniae

21 January 2018

1 reference

Crystal structure of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-diaminopimelate ligase from Escherichia coli

21 January 2018

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The bacterial cell wall as a source of antibacterial targets

21 January 2018

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Recent advances in the formation of the bacterial peptidoglycan monomer unit

21 January 2018

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Functional and biochemical analysis of Chlamydia trachomatis MurC, an enzyme displaying UDP-N-acetylmuramate:amino acid ligase activity

21 January 2018

1 reference

Peptidoglycan plasticity in bacteria: stress-induced peptidoglycan editing by noncanonical D-amino acids

21 January 2018

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Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF

21 January 2018

1 reference

Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F.

21 January 2018

1 reference

Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme

21 January 2018

1 reference

Structural studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase.

21 January 2018

1 reference

Structure-based design approaches to cell wall biosynthesis inhibitors

21 January 2018

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Development of novel inhibitors targeting intracellular steps of peptidoglycan biosynthesis

21 January 2018

1 reference

Structural and functional characterization of enantiomeric glutamic acid derivatives as potential transition state analogue inhibitors of MurD ligase

21 January 2018

1 reference

Staphylococcus aureus MurC participates in L-alanine recognition via histidine 343, a conserved motif in the shallow hydrophobic pocket

21 January 2018

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D-amino acids govern stationary phase cell wall remodeling in bacteria

21 January 2018

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Platforms for antibiotic discovery

21 January 2018

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A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis.

21 January 2018

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Has the era of untreatable infections arrived?

21 January 2018

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Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure

21 January 2018

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Characterization of Chlamydia MurC-Ddl, a fusion protein exhibiting D-alanyl-D-alanine ligase activity involved in peptidoglycan synthesis and D-cycloserine sensitivity

21 January 2018

1 reference

Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae

21 January 2018

1 reference

Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis

21 January 2018

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Molecular basis of bacterial outer membrane permeability

21 January 2018

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

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Targeted molecular dynamics simulation studies of binding and conformational changes in E. coli MurD.

21 January 2018

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MurD ligase from E. coli: Tetrahedral intermediate formation study by hybrid quantum mechanical/molecular mechanical replica path method.

21 January 2018

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Discovery of novel benzene 1,3-dicarboxylic acid inhibitors of bacterial MurD and MurE ligases by structure-based virtual screening approach

21 January 2018

1 reference

Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF).

21 January 2018

1 reference

Specificity Determinants for Lysine Incorporation in Staphylococcus aureus Peptidoglycan as Revealed by the Structure of a MurE Enzyme Ternary Complex

21 January 2018

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Structural and functional similarities in the ADP-forming amide bond ligase superfamily: implications for a substrate-induced conformational change in folylpolyglutamate synthetase.

21 January 2018

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The bacterial cell envelope

21 January 2018

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Novel inhibitors of bacterial cell wall synthesis.

21 January 2018

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Does the cell wall of bacteria remain a viable source of targets for novel antibiotics?

21 January 2018

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Challenges of antibacterial discovery

21 January 2018

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Viable screening targets related to the bacterial cell wall.

21 January 2018

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The binding mode of second-generation sulfonamide inhibitors of MurD: clues for rational design of potent MurD inhibitors

21 January 2018

1 reference

Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligases.

21 January 2018

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ATP-binding site of bacterial enzymes as a target for antibacterial drug design

21 January 2018

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Structure, function and dynamics in the mur family of bacterial cell wall ligases

21 January 2018

1 reference

Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid

21 January 2018

1 reference

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution

21 January 2018

1 reference

Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD.

21 January 2018

1 reference

Ability of PknA, a mycobacterial eukaryotic-type serine/threonine kinase, to transphosphorylate MurD, a ligase involved in the process of peptidoglycan biosynthesis

21 January 2018

1 reference

Peptidoglycan structure and architecture

21 January 2018

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Positioning cell wall synthetic complexes by the bacterial morphogenetic proteins MreB and MreD.

21 January 2018

1 reference

Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution

21 January 2018

1 reference

New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation

21 January 2018

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Combinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors

21 January 2018

1 reference

Invariant Amino Acids in the Mur Peptide Synthetases of Bacterial Peptidoglycan Synthesis and Their Modification by Site-Directed Mutagenesis in the UDP-MurNAc:l-Alanine Ligase from Escherichia coli

21 January 2018

1 reference

Phosphinate Inhibitors of UDP-N-Acetylmuramoyl-L-Alanyl-D-Glutamate:L-Lysine Ligase (MurE)

21 January 2018

1 reference

5-Benzylidenethiazolidin-4-ones as Multitarget Inhibitors of Bacterial Mur Ligases

21 January 2018

1 reference

Virtual screening for potential inhibitors of bacterial MurC and MurD ligases

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/MMI.12758

1 reference

release_7z6lkoea6bbwvbmxixb2uvxxea

31 August 2017

1 reference

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https://api.fatcat.wiki/v0/release/7z6lkoea6bbwvbmxixb2uvxxea

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24 November 2022

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