(Q38240603)

31 August 2017

title

Genetic, molecular and physiological mechanisms involved in human obesity: Society for Endocrinology Medal Lecture 2012. (English)

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31 August 2017

1

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31 August 2017

publication date

22 September 2014

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31 August 2017

published in

Clinical Endocrinology

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31 August 2017

volume

82

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31 August 2017

issue

1

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page(s)

23-28

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Genetics of obesity in adult adoptees and their biological siblings

31 August 2017

cites work

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Positional cloning of the mouse obese gene and its human homologue

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Role of leptin in the neuroendocrine response to fasting

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

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Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

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Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor

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Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice

21 January 2018

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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

21 January 2018

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Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients

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Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery

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Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

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Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

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Modulation of blood pressure by central melanocortinergic pathways

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Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling

21 January 2018

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SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.

21 January 2018

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Large, rare chromosomal deletions associated with severe early-onset obesity

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Human SH2B1 mutations are associated with maladaptive behaviors and obesity

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Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

21 January 2018

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Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity

21 January 2018

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A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

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Brain-derived neurotrophic factor and obesity in the WAGR syndrome

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Rare variants in single-minded 1 (SIM1) are associated with severe obesity

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Deletion of the SIM1 gene (6q16.2) in a patient with a Prader-Willi-like phenotype

21 January 2018

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Prader-Willi syndrome: advances in genetics, pathophysiology and treatment

21 January 2018

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KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation

21 January 2018

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AMP-activated protein kinase: a target for drugs both ancient and modern

21 January 2018

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Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus

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Pharmacological Chaperones Restore Function to MC4R Mutants Responsible for Severe Early-Onset Obesity

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The role of depot fat in the hypothalamic control of food intake in the rat.

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21 January 2018

Identifiers

DOI

10.1111/CEN.12588

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31 August 2017

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