(Q38250126)

1 September 2017

1 reference

title

Novel tactics for designing water-soluble molecules in drug discovery (English)

1 reference

1 September 2017

1 reference

Michael A Walker

1

1 reference

1 September 2017

language of work or name

English

0 references

publication date

17 September 2014

1 reference

Expert Opinion on Drug Discovery

1 September 2017

published in

1 reference

1 September 2017

volume

9

1 reference

1 September 2017

issue

12

1 reference

1 September 2017

page(s)

1421-1433

1 reference

Property-based design: optimization of drug absorption and pharmacokinetics

1 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

The influence of the 'organizational factor' on compound quality in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Molecular properties that influence the oral bioavailability of drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Guidance in the setting of drug particle size specifications to minimize variability in absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

When poor solubility becomes an issue: from early stage to proof of concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Bridging solubility between drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Estimation of the aqueous solubility I: application to organic nonelectrolytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Estimation of aqueous solubility of organic compounds by using the general solubility equation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Molecular characteristics for solid-state limited solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Interactions of Water with Nonpolar Solutes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Hydrogen bonding. 32. An analysis of water-octanol and water-alkane partitioning and the delta log P parameter of seiler.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Predicting and tuning physicochemical properties in lead optimization: amine basicities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

The pK(BHX) database: toward a better understanding of hydrogen-bond basicity for medicinal chemists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Four-membered heterocycles-containing 4-anilino-quinazoline derivatives as epidermal growth factor receptor (EGFR) kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

On the validity of Wallach's rule: on the density and stability of racemic crystals compared with their chiral counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Beyond size, ionization state, and lipophilicity: influence of molecular topology on absorption, distribution, metabolism, excretion, and toxicity for druglike compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Matched molecular pair analysis in drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Fluorinated compounds in medicinal chemistry: recent applications, synthetic advances and matched-pair analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

The methylation effect in medicinal chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Fluorocyclopropyl quinolones. 1. Synthesis and structure-activity relationships of 1-(2-fluorocyclopropyl)-3-pyridonecarboxylic acid antibacterial agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Pyrazolopyridine inhibitors of B-Raf(V600E). Part 3: an increase in aqueous solubility via the disruption of crystal packing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Escape from flatland: increasing saturation as an approach to improving clinical success

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

A solid-state chemist's view of the crystal polymorphism of organic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

How molecules stick together in organic crystals: weak intermolecular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Quantitative Ranking of Crystal Packing Modes by Systematic Calculations on Potential Energies and Vibrational Amplitudes of Molecular Dimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Multi-parameter optimization: identifying high quality compounds with a balance of properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Ligand efficiency: a useful metric for lead selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Ligand efficiency indices as guideposts for drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

Current trends in lead discovery: are we looking for the appropriate properties?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.960839

10.1517/17460441.2014.960839

21 January 2018

Identifiers

DOI

1 reference

1 September 2017

1 reference