(Q38272432)

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Involvement of the amino-terminal beta-hairpin of the Aspergillus ribotoxins on the interaction with membranes and nonspecific ribonuclease activity.

scientific article published on August 2001

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scholarly article

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11468362%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Involvement of the amino-terminal beta-hairpin of the Aspergillus ribotoxins on the interaction with membranes and nonspecific ribonuclease activity (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11468362%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Lucía García-Ortega

1

1 reference

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9 November 2019

Javier Lacadena

2

1 reference

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9 November 2019

Mercedes Oñaderra

4

1 reference

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9 November 2019

José G Gavilanes

9

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9 November 2019

author name string

J M Mancheño

3

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9 November 2019

R Kao

5

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9 November 2019

J Davies

6

1 reference

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9 November 2019

N Olmo

7

1 reference

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9 November 2019

Pozo AM

8

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9 November 2019

publication date

1 August 2001

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9 November 2019

Protein Science

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11468362%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

10

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9 November 2019

8

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Europe PubMed Central

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9 November 2019

1658-1668

1 reference

Europe PubMed Central

PMC publication ID

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9 November 2019

ALPHA SARCIN, A NEW ANTITUMOR AGENT. II. FERMENTATION AND ANTITUMOR SPECTRUM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

ALPHA SARCIN, A NEW ANTITUMOR AGENT. I. ISOLATION, PURIFICATION, CHEMICAL COMPOSITION, AND THE IDENTITY OF A NEW AMINO ACID.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

The highly refined solution structure of the cytotoxic ribonuclease alpha-sarcin reveals the structural requirements for substrate recognition and ribonucleolytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

The two faces of the Escherichia coli 23 S rRNA sarcin/ricin domain: the structure at 1.11 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Ribotoxins are a more widespread group of proteins within the filamentous fungi than previously believed.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Crystal structure of the ribosomal RNA domain essential for binding elongation factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Probing the active site of mitogillin, a fungal ribotoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Insights into specificity of cleavage and mechanism of cell entry from the crystal structure of the highly specific Aspergillus ribotoxin, restrictocin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

MOLMOL: a program for display and analysis of macromolecular structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

The sarcin/ricin loop, a modular RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Thermal unfolding of the cytotoxin alpha-sarcin: phospholipid binding induces destabilization of the protein structure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Crystal structure of Ustilago sphaerogena ribonuclease U2 at 1.8 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Use of resonance energy transfer to monitor membrane fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

The site of action of alpha-sarcin on eukaryotic ribosomes. The sequence at the alpha-sarcin cleavage site in 28 S ribosomal ribonucleic acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

The ribonuclease activity of the cytotoxin alpha-sarcin. The characteristics of the enzymatic activity of alpha-sarcin with ribosomes and ribonucleic acids as substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Protein stability curves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

RNA-protein interaction. An analysis with RNA oligonucleotides of the recognition by alpha-sarcin of a ribosomal domain critical for function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Ribotoxin recognition of ribosomal RNA and a proposal for the mechanism of translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Specific cleavage of ribosomal RNA caused by alpha sarcin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

6 September 2017

Membrane interaction of a beta-structure-forming synthetic peptide comprising the 116-139th sequence region of the cytotoxic protein alpha-sarcin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

14 September 2017

Fungal ribotoxins: a family of naturally engineered targeted toxins?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

27 September 2017

Sequence determination and molecular characterization of gigantin, a cytotoxic protein produced by the mould Aspergillus giganteus IFO 5818.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

23 June 2018

Translocation of alpha-sarcin across the lipid bilayer of asolectin vesicles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

23 June 2018

Kinetic study of the aggregation and lipid mixing produced by alpha-sarcin on phosphatidylglycerol and phosphatidylserine vesicles: stopped-flow light scattering and fluorescence energy transfer measurements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

23 June 2018

The mode of action of restrictocin and mitogillin on eukaryotic ribosomes. Inhibition of brain protein synthesis, cleavage and sequence of the ribosomal RNA fragment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

23 June 2018

The ribosomes of Aspergillus giganteus are sensitive to the cytotoxic action of alpha-sarcin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

23 June 2018

Study of the interaction between the antitumour protein alpha-sarcin and phospholipid vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

23 June 2018

Fusion of phospholipid vesicles produced by the anti-tumour protein alpha-sarcin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

23 June 2018

Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

23 June 2018

Histidine-40 of ribonuclease T1 acts as base catalyst when the true catalytic base, glutamic acid-58, is replaced by alanine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

23 June 2018

Characterization of pKa values and titration shifts in the cytotoxic ribonuclease alpha-sarcin by NMR. Relationship between electrostatic interactions, structure, and catalytic function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

31 August 2018

Overproduction and purification of biologically active native fungal alpha-sarcin in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

31 August 2018

Substitution of histidine-137 by glutamine abolishes the catalytic activity of the ribosome-inactivating protein alpha-sarcin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374091

31 August 2018

Ribonuclease T1: Structure, Function, and Stability

1 reference

https://api.crossref.org/works/10.1110%2FPS.9601

21 January 2018

Role of histidine-50, glutamic acid-96, and histidine-137 in the ribonucleolytic mechanism of the ribotoxin alpha-sarcin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assignment of the contribution of the tryptophan residues to the spectroscopic and functional properties of the ribotoxin alpha-sarcin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear magnetic resonance study on the microenvironments of histidine residues of ribonuclease T1 and carboxymethylated ribonuclease T1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity staining of nucleolytic enzymes after sodium dodecyl sulfate-polyacrylamide gel electrophoresis: Use of aqueous isopropanol to remove detergent from gels

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational study of the antitumor protein α-sarcin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic study of the cytotoxic effect of alpha-sarcin, a ribosome inactivating protein from Aspergillus giganteus, on tumour cell lines: protein biosynthesis inhibition and cell binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for the catalytic mechanism and substrate specificity of the ribonuclease α-sarcin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single amino acid substitutions affecting the specificity of the fungal ribotoxin mitogillin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The solubility of the ribotoxin alpha-sarcin, produced as a recombinant protein in Escherichia coli, is increased in the presence of thioredoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single amino acid substitution in ribonucleolytic toxin restrictocin abolishes its specific substrate recognition activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptide of nine amino acid residues from alpha-sarcin cytotoxin is a membrane-perturbing structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytotoxin α-sarcin behaves as a cyclizing ribonuclease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomerization of the cytotoxin α-sarcin associated with phospholipid membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dissection of mitogillin reveals that the fungal ribotoxins are a family of natural genetically engineered ribonucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hirsutellin A Displays Significant Homology to Microbial Extracellular Ribonucleases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colorimetric assay methods for free and phosphorylated glyceric acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bovine Seminal Ribonuclease Destabilizes Negatively Charged Membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predictive study of the conformation of the cytotoxic protein α-sarcin: a structural model to explain α-sarcin-membrane interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase of Solubility of Foreign Proteins in Escherichia coli by Coproduction of the Bacterial Thioredoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11468362

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1110/PS.9601

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11468362%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11468362%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11468362%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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