(Q38297215)

1 September 2017

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title

Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects (English)

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1 September 2017

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R A Stull

1

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PubMed ID

7596980

1 September 2017

F C Szoka

series ordinal

2

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1 September 2017

1 April 1995

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1 September 2017

Pharmaceutical Research

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1 September 2017

12

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1 September 2017

465-483

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1 September 2017

4

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Cleavage of oligoribonucleotides by a ribozyme derived from the hepatitis .delta. virus RNA sequence

1 September 2017

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12 December 2020

Inhibition of gene expression by triple helix-directed DNA cross-linking at specific sites.

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12 December 2020

Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1

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12 December 2020

Incorporation of the catalytic domain of a hammerhead ribozyme into antisense RNA enhances its inhibitory effect on the replication of human immunodeficiency virus type 1.

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12 December 2020

Mutagenesis of the hairpin ribozyme

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12 December 2020

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12 December 2020

Progress toward human gene therapy

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12 December 2020

Site-Specific Cleavage of natural mRNA sequences by newly designed hairpin catalytic RNAs

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12 December 2020

DNA triple-helix specific intercalators as antigene enhancers: unfused aromatic cations

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12 December 2020

Liposomes as a drug delivery system for antisense oligonucleotides

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12 December 2020

Characterization of a triple helix-specific ligand. BePI (3-methoxy-7H-8-methyl-11- [(3'-amino)propylamino]-benzo[e]pyrido[4,3-b]indole) intercalates into both double-helical and triple-helical DNA.

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12 December 2020

Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template

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12 December 2020

Inhibition of c-Ha-ras gene expression by hammerhead ribozymes containing a stable C(UUCG)G hairpin loop

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12 December 2020

Rational design of self-cleaving pre-tRNA-ribonuclease P RNA conjugates

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12 December 2020

A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus-specific proteins in MDCK cells

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12 December 2020

A unique c-myc-targeted triplex-forming oligonucleotide inhibits the growth of ovarian and cervical carcinomas in vitro

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12 December 2020

A triple helix-forming oligonucleotide-intercalator conjugate acts as a transcriptional repressor via inhibition of NF kappa B binding to interleukin-2 receptor alpha-regulatory sequence

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12 December 2020

Sequence-specific photo-induced cross-linking of the two strands of double-helical DNA by a psoralen covalently linked to a triple helix-forming oligonucleotide

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12 December 2020

Inhibition of T7 RNA polymerase initiation by triple-helical DNA complexes: a model for artificial gene repression

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12 December 2020

Activation of HIV-specific ribozyme activity by self-cleavage

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12 December 2020

Cleavage of human MDR1 mRNA by a hammerhead ribozyme

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12 December 2020

Intracellular distribution of microinjected antisense oligonucleotides

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12 December 2020

Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles

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12 December 2020

The influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex formation

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12 December 2020

Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme.

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12 December 2020

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

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12 December 2020

Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene

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12 December 2020

Triple helix formation inhibits transcription elongation in vitro

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12 December 2020

Expression of a chimeric ribozyme gene results in endonucleolytic cleavage of target mRNA and a concomitant reduction of gene expression in vivo

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12 December 2020

Directed evolution of an RNA enzyme

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12 December 2020

Polyalkylcyanoacrylate nanoparticles as polymeric carriers for antisense oligonucleotides

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12 December 2020

Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme

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12 December 2020

Transcriptional inhibition of the bacteriophage T7 early promoter region by oligonucleotide triple helix formation

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12 December 2020

Triplex formation prevents Sp1 binding to the dihydrofolate reductase promoter

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12 December 2020

A ribozyme with DNA in the hybridising arms displays enhanced cleavage ability

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12 December 2020

Evidence that a triplex-forming oligodeoxyribonucleotide binds to the c-myc promoter in HeLa cells, thereby reducing c-myc mRNA levels

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12 December 2020

Cytoplasmic delivery of ribozymes leads to efficient reduction in alpha-lactalbumin mRNA levels in C127I mouse cells

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12 December 2020

Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site

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12 December 2020

Sequence-specific artificial photo-induced endonucleases based on triple helix-forming oligonucleotides

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12 December 2020

RNA catalytic properties of the minimum (-)sTRSV sequence

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12 December 2020

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

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12 December 2020

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

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12 December 2020

The Tetrahymena ribozyme acts like an RNA restriction endonuclease

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12 December 2020

Specificity of ribozyme designed for mutated DHFR mRNA.

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12 December 2020

Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages

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12 December 2020

Drug targeting: synthesis and endocytosis of oligonucleotide-neoglycoprotein conjugates

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12 December 2020

Ribozyme mediated destruction of influenza A virus in vitro and in vivo

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12 December 2020

Substrate sequence effects on "hammerhead" RNA catalytic efficiency

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12 December 2020

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12 December 2020

In vitro and in vivo pharmacologic activities of antisense oligonucleotides

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12 December 2020

Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2'-O-methylation

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12 December 2020

Computer prediction of RNA structure

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12 December 2020

Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates

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12 December 2020

Protein enhancement of hammerhead ribozyme catalysis

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12 December 2020

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer

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12 December 2020

Sequence specificity in triple-helix formation: experimental and theoretical studies of the effect of mismatches on triplex stability

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12 December 2020

In vitro cleavage of HIV-1 vif RNA by a synthetic ribozyme

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12 December 2020

Ribozymes that cleave an RNA sequence from human immunodeficiency virus: the effect of flanking sequence on rate

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12 December 2020

Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo

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12 December 2020

Intramolecular triplex potential sequence within a gene down regulates its expression in vivo

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12 December 2020

Repression of bacteriophage promoters by DNA and RNA oligonucleotides

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12 December 2020

Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication

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12 December 2020

Ribozymes correctly cleave a model substrate and endogenous RNA in vivo.

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12 December 2020

Ribozyme-mediated cleavage of the bcr/abl transcript expressed in chronic myeloid leukemia

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12 December 2020

Cleavage of specific sites of RNA by designed ribozymes

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12 December 2020

Ribozyme-targeting elucidates a direct role of pleiotrophin in tumor growth

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12 December 2020

Reversible inhibition of gene expression by a psoralen functionalized triple helix forming oligonucleotide in intact cells

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12 December 2020

An anti-lymphocytic choriomeningitis virus ribozyme expressed in tissue culture cells diminishes viral RNA levels and leads to a reduction in infectious virus yield

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12 December 2020

Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme

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12 December 2020

External Guide Sequences for an RNA Enzyme

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12 December 2020

Oligonucleotide clamps arrest DNA synthesis on a single-stranded DNA target

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12 December 2020

Second structural motif for recognition of DNA by oligonucleotide-directed triple-helix formation

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12 December 2020

Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate

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12 December 2020

Specific association between an endoribonucleolytic sequence from a satellite RNA and a substrate analogue containing a 2'-5' phosphodiester

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12 December 2020

Intracellular immunization of human T cells with a hairpin ribozyme against human immunodeficiency virus type 1.

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12 December 2020

Ribozyme-mediated modulation of human O6-methylguanine-DNA methyltransferase expression.

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12 December 2020

The utility of an anti-fos ribozyme in reversing cisplatin resistance in human carcinomas.

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12 December 2020

Binding and cleavage of nucleic acids by the "hairpin" ribozyme

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12 December 2020

Ribozyme mediated destruction of RNA in vivo

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12 December 2020

Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides

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12 December 2020

Specific inhibition of transcription by triple helix-forming oligonucleotides

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12 December 2020

Model substrates for an RNA enzyme

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12 December 2020

Inhibition of restriction endonuclease cleavage site via triple helix formation by homopyrimidine phosphorothioate oligonucleotides

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12 December 2020

Ribozymes which cleave arenavirus RNAs: identification of susceptible target sites and inhibition by target site secondary structure

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12 December 2020

A kinetic and thermodynamic framework for the hammerhead ribozyme reaction

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12 December 2020

Tat-mediated delivery of heterologous proteins into cells

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12 December 2020

Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture

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12 December 2020

Modulation of oligonucleotide duplex and triplex stability via hydrophobic interactions

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12 December 2020

Selective cleavage of closely-related mRNAs by synthetic ribozymes

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12 December 2020

Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila.

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12 December 2020

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

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12 December 2020

Novel guanosine requirement for catalysis by the hairpin ribozyme

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12 December 2020

Ribozyme-mediated cleavage of the BCRABL oncogene transcript: in vitro cleavage of RNA and in vivo loss of P210 protein-kinase activity

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12 December 2020

Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein.

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12 December 2020

Development of antisense therapeutics. Implications for cancer gene therapy

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12 December 2020

Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices

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12 December 2020

Nomenclature for incompletely specified bases in nucleic acid sequences: recommendations 1984.

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12 December 2020

Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme

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12 December 2020

Construction and characterization of lck- and fyn-specific tRNA: ribozyme chimeras

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12 December 2020

Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA.

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12 December 2020

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

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12 December 2020

Ribozymes as potential anti-HIV-1 therapeutic agents.

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12 December 2020

Deriving a 67-Nucleotidetrans-Cleaving Ribozyme from the Hepatitis Delta Virus Antigenomic RNA

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12 December 2020

Ribozyme cleaves rex/tax mRNA and inhibits bovine leukemia virus expression

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12 December 2020

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo.

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12 December 2020

Reduced beta 2-microglobulin mRNA levels in transgenic mice expressing a designed hammerhead ribozyme

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12 December 2020

Effect of abasic linker substitution on triplex formation, Sp1 binding, and specificity in an oligonucleotide targeted to the human Ha-ras promoter

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12 December 2020

Ribozymes that cleave potato leafroll virus RNA within the coat protein and polymerase genes

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12 December 2020

Oligonucleotide-directed triple helix formation at adjacent oligopurine and oligopyrimidine DNA tracts by alternate strand recognition

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12 December 2020

Purification and Properties of a Specific Escherichia coli Ribonuclease which Cleaves a Tyrosine Transfer Ribonucleic Acid Precursor

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12 December 2020

In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions.

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12 December 2020

Inhibition of restriction endonuclease cleavage via triple helix formation by homopyrimidine oligonucleotides

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12 December 2020

Selection of antisense oligonucleotides on the basis of genomic frequency of the target sequence.

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12 December 2020

Kinetics and thermodynamics of triple-helix formation: effects of ionic strength and mismatches

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12 December 2020

An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis

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12 December 2020

In vitro and in vivo effects of synthetic ribozymes targeted against BCR/ABL mRNA

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12 December 2020

7,8-Dihydro-8-oxoadenine as a replacement for cytosine in the third strand of triple helices. Triplex formation without hypochromicity

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12 December 2020

Reversal of drug sensitivity in multidrug-resistant tumor cells by an MDR1 (PGY1) ribozyme.

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12 December 2020

Oligonucleotide analogues as potential chemotherapeutic agents

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12 December 2020

Regulation of gene expression with double-stranded phosphorothioate oligonucleotides

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12 December 2020

Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro

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12 December 2020

Linkage structures strongly influence the binding cooperativity of DNA intercalators conjugated to triplex forming oligonucleotides

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12 December 2020

Inhibition of T7 and T3 RNA polymerase directed transcription elongation in vitro

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12 December 2020

Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site

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12 December 2020

Construction of a series of several self-cleaving RNA duplexes using synthetic 21-mers

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12 December 2020

'Hairpin' catalytic RNA model: evidence for helices and sequence requirement for substrate RNA.

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12 December 2020

Comparison of different ribozymes for efficient and specific cleavage of BCR/ABL related mRNAs.

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12 December 2020

A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1

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12 December 2020

Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro

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12 December 2020

Antisense catalytic RNAs as therapeutic agents.

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12 December 2020

Sequence-specific cleavage of double helical DNA by triple helix formation.

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12 December 2020

Extension of the range of recognition sequences for triple helix formation by oligonucleotides containing guanines and thymines

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12 December 2020

Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes

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12 December 2020

The single-stranded DNA aptamer-binding site of human thrombin.

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12 December 2020

A photo-cross-linkable tertiary structure motif found in functionally distinct RNA molecules is essential for catalytic function of the hairpin ribozyme

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12 December 2020

Ionic requirements for RNA binding, cleavage, and ligation by the hairpin ribozyme

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12 December 2020

AUA-cleaving hammerhead ribozymes: attempted selection for improved cleavage

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12 December 2020

A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA.

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12 December 2020

Triple helix-specific ligands

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12 December 2020

Antisense and Antigene Properties of Peptide Nucleic Acids

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12 December 2020

Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.

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12 December 2020

Double-stranded phosphorothioate oligonucleotide modulation of gene expression

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12 December 2020

Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting

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12 December 2020

Inhibition of simian virus 40 DNA replication in CV-1 cells by an oligodeoxynucleotide covalently linked to an intercalating agent

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12 December 2020

Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity

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12 December 2020

Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type 1.

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12 December 2020

Detailed study of sequence-specific DNA cleavage of triplex-forming oligonucleotides linked to 1,10-phenanthroline.

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12 December 2020

Binding of triple helix forming oligonucleotides to sites in gene promoters

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12 December 2020

Self-stabilized antisense oligodeoxynucleotide phosphorothioates: properties and anti-HIV activity

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12 December 2020

Specific gene suppression by engineered ribozymes in monkey cells

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12 December 2020

Targeted cleavage of mRNA by human RNase P

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12 December 2020

Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates

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12 December 2020

Triple helix formation with short oligonucleotide-intercalator conjugates matching the HIV-1 U3 LTR end sequence

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12 December 2020

Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy in AIDS.

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12 December 2020

A circular trans-acting hepatitis delta virus ribozyme

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12 December 2020

Trans cleavage of RNA substrates by an HDV-derived ribozyme

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12 December 2020

Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme

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12 December 2020

Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA

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12 December 2020

Inhibition of Klenow fragment DNA polymerase on double-helical templates by oligonucleotide-directed triple-helix formation

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12 December 2020

H-ras ribozyme-mediated alteration of the human melanoma phenotype

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12 December 2020

Evidence for spontaneous circle formation in the replication of the satellite RNA of tobacco ringspot virus

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12 December 2020

Localized RNAs and their functions

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12 December 2020

Delivery of c-myc antisense phosphorothioate oligodeoxynucleotides to hematopoietic cells in culture by liposome fusion: specific reduction in c-myc protein expression correlates with inhibition of cell growth and DNA synthesis

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12 December 2020

Hammerhead ribozyme cleavage of hamster prion pre-mRNA in complex cell-free model systems

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12 December 2020

Preformed ribozyme destroys tumour necrosis factor mRNA in human cells

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12 December 2020

Can hammerhead ribozymes be efficient tools to inactivate gene function?

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12 December 2020

Target Detection Assay (TDA): a versatile procedure to determine DNA binding sites as demonstrated on SP1 protein

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12 December 2020

Sequence limitations of triple helix formation by alternate-strand recognition.

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12 December 2020

Kinetic analysis of oligodeoxyribonucleotide-directed triple-helix formation on DNA.

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12 December 2020

Using RNAFOLD to predict the activity of small catalytic RNAs.

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12 December 2020

Inhibition of transcription of HIV-1 in infected human cells by oligodeoxynucleotides designed to form DNA triple helices

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12 December 2020

Four ribose 2'-hydroxyl groups essential for catalytic function of the hairpin ribozyme

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12 December 2020

Effective incorporation of 2'-O-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol

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12 December 2020

Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better

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12 December 2020

The new frontier: gene and oligonucleotide therapy

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12 December 2020

Selective cleavage of bcr-abl chimeric RNAs by a ribozyme targeted to non-contiguous sequences

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12 December 2020

Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3'-terminus and their interaction with DNA within mammalian cells

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12 December 2020

Triple-helix formation by alpha oligodeoxynucleotides and alpha oligodeoxynucleotide-intercalator conjugates

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12 December 2020

Relief of triple-helix-mediated promoter inhibition by elongating RNA polymerases

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12 December 2020

Inhibition of HIV-1 replication by ribozymes that show poor activity in vitro.

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12 December 2020

Oligonucleotide inhibition of IL2R alpha mRNA transcription by promoter region collinear triplex formation in lymphocytes

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12 December 2020

Delivery of antisense oligonucleotides by poly(L-lysine) conjugation and liposome encapsulation

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12 December 2020

Sequences required for self-catalysed cleavage of the satellite RNA of tobacco ringspot virus

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12 December 2020

In vivo transcription of a progesterone-responsive gene is specifically inhibited by a triplex-forming oligonucleotide

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12 December 2020

Targeted delivery of antisense oligonucleotides by molecular conjugates

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12 December 2020

Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates

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12 December 2020

Functional characterization of a U5 ribozyme: intracellular suppression of human immunodeficiency virus type 1 expression

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12 December 2020

Rapid nuclear accumulation of injected oligodeoxyribonucleotides

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12 December 2020

In vitro selection and evolution of RNA: applications for catalytic RNA, molecular recognition, and drug discovery.

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12 December 2020

Site-specific inhibition of EcoRI restriction/modification enzymes by a DNA triple helix

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12 December 2020

The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions

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12 December 2020

Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein

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12 December 2020

Reversal of the malignant phenotype by an anti-ras ribozyme

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12 December 2020

Secondary structure of the self-cleaving RNA of hepatitis delta virus: applications to catalytic RNA design

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12 December 2020

In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits

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12 December 2020

The polypurine tract, PPT, of HIV as target for antisense and triple-helix-forming oligonucleotides

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12 December 2020

Cleavage of full-length beta APP mRNA by hammerhead ribozymes

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12 December 2020

Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication

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12 December 2020

Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation

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12 December 2020

Inhibition of gene transcription by purine rich triplex forming oligodeoxyribonucleotides

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12 December 2020

Oligonucleotide-mediated triple helix formation using an N3-protonated deoxycytidine analog exhibiting pH-independent binding within the physiological range

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12 December 2020

Design and specificity of hammerhead ribozymes against calretinin mRNA.

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12 December 2020

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure

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12 December 2020

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

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12 December 2020

Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme.

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12 December 2020

Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites

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12 December 2020

Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line.

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12 December 2020

Optimization of an anti-HIV hairpin ribozyme by in vitro selection

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12 December 2020

Sequence requirements of the hammerhead RNA self-cleavage reaction

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12 December 2020

A small catalytic oligoribonucleotide

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12 December 2020

Prevention of human immunodeficiency virus type 1 integrase expression in Escherichia coli by a ribozyme

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12 December 2020

Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates.

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12 December 2020

Simple RNA enzymes with new and highly specific endoribonuclease activities

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12 December 2020

Amplification, mutation and selection of catalytic RNA.

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12 December 2020

Autolytic processing of dimeric plant virus satellite RNA

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12 December 2020

Extensive phosphorothioate substitution yields highly active and nuclease-resistant hairpin ribozymes

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12 December 2020

In vitro selection of RNA molecules that bind specific ligands

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12 December 2020

Identifiers

DOI

10.1023/A:1016281324761

1 reference

1 September 2017

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PubMed ID

7596980