(Q38300297)

English

Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein

scientific article published on 30 May 2001

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 September 2017

Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

author name string

Koutsodontis G

1

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Tentes I

2

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Papakosta P

3

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Moustakas A

4

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Kardassis D

5

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

language of work or name

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publication date

30 May 2001

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Europe PubMed Central

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1 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

1 September 2017

276

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Europe PubMed Central

PubMed publication ID

1 September 2017

31

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

29116-29125

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

Cdk inhibitors in development and cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p21 Is a Component of Active Cell Cycle Kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p21-containing cyclin kinases exist in both active and inactive states

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Inhibition of cyclin-dependent kinases by p21

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Genetic determinants of p53-induced apoptosis and growth arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

The expanding role of cell cycle regulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

MDM2--master regulator of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Dysregulation of apoptosis in cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Induction of the growth inhibitor IGF-binding protein 3 by p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p53 in embryonic development: maintaining a fine balance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Irradiation induces WAF1 expression through a p53-independent pathway in KG-1 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Involvement of p21(WAF1/Cip1), CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Transcriptional regulation by the Sp family proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Growth/cell cycle regulation of Sp1 phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Functional interference of Sp1 and NF-kappaB through the same DNA binding site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

The MCK enhancer contains a p53 responsive element

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Involvement of the Sp3 transcription factor in induction of p21Cip1/WAF1 in keratinocyte differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Synergistic activation of transcription by CBP and p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Antisense-mediated depletion of p300 in human cells leads to premature G1 exit and up-regulation of c-MYC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Identification and classification of p53-regulated genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p53 and Sp1 interact and cooperate in the tumor necrosis factor-induced transcriptional activation of the HIV-1 long terminal repeat

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

p53 regulates caveolin gene transcription, cell cholesterol, and growth by a novel mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Ectopic p21(WAF1) expression induces differentiation-specific cell cycle changes in PC12 cells characteristic of nerve growth factor treatment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104130200

21 January 2018

Identifiers

10.1074/JBC.M104130200

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 September 2017

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