(Q38305508)

2 September 2017

title

Two novel glucagon receptor antagonists prove effective therapeutic agents in high-fat-fed and obese diabetic mice (English)

1 reference

2 September 2017

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25060150%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Zara J Franklin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25060150%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Nigel Irwin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25060150%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

F P M O'Harte

1

1 reference

2 September 2017

Z J Franklin

2

1 reference

2 September 2017

N Irwin

3

1 reference

2 September 2017

publication date

19 August 2014

1 reference

Diabetes, Obesity and Metabolism

2 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25060150%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25060150%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25060150%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

1214-1222

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25060150%20AND%20SRC:MED&resulttype=core&format=json

Glucagon and regulation of glucose metabolism

13 June 2020

cites work

1 reference

Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains

21 January 2018

1 reference

Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity.

21 January 2018

1 reference

Glycemic control in mice with targeted disruption of the glucagon receptor gene

21 January 2018

1 reference

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

21 January 2018

1 reference

Glucagon physiology and pathophysiology in the light of new advances

21 January 2018

1 reference

Identification of alkylidene hydrazides as glucagon receptor antagonists.

21 January 2018

1 reference

Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.

21 January 2018

1 reference

Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans

21 January 2018

1 reference

A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects

21 January 2018

1 reference

Glucagon antagonism as a potential therapeutic target in type 2 diabetes

21 January 2018

1 reference

Incretin-based therapies for type 2 diabetes mellitus: a review of direct comparisons of efficacy, safety and patient satisfaction

21 January 2018

1 reference

desHis¹Glu⁹-glucagon-[mPEG] and desHis¹Glu⁹(Lys³⁰PAL)-glucagon: long-acting peptide-based PEGylated and acylated glucagon receptor antagonists with potential antidiabetic activity.

21 January 2018

1 reference

Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists

21 January 2018

1 reference

Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties.

21 January 2018

1 reference

Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes

21 January 2018

1 reference

Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.

21 January 2018

1 reference

Comparison of the metabolic effects of sustained CCK1 receptor activation alone and in combination with upregulated leptin signalling in high-fat-fed mice

21 January 2018

1 reference

Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia

21 January 2018

1 reference

Emerging combinatorial hormone therapies for the treatment of obesity and T2DM.

21 January 2018

1 reference

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice

21 January 2018

1 reference

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

21 January 2018

1 reference

Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice

21 January 2018

1 reference

International Union of Pharmacology. XXXV. The glucagon receptor family

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/DOM.12360

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25060150%20AND%20SRC:MED&resulttype=core&format=json

release_7rygownf4bb2bibco5mmf3rxiu

13 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7rygownf4bb2bibco5mmf3rxiu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference