(Q38309810)

English

Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor

scientific article published on 12 January 2014

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor (English)

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

0 references

author name string

Shashi Gupta

1

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Masao Hirota

2

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Sheela M Waugh

3

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Ikuo Murakami

4

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Tomoki Suzuki

5

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Masahiro Muraguchi

6

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Masafumi Shibamori

7

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Yuichi Ishikawa

8

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Thale C Jarvis

9

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Jeffrey D Carter

10

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Chi Zhang

11

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Bharat Gawande

12

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Michael Vrkljan

13

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Nebojsa Janjic

14

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Daniel J Schneider

15

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

language of work or name

0 references

publication date

12 January 2014

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

289

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

12

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

8706-8719

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Stabilized Interleukin-6 receptor binding RNA aptamers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Interleukin-6 signaling pathway in targeted therapy for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Hitting a complex target: an update on interleukin-6 trans-signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

RNA-based therapeutics: current progress and future prospects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Therapeutic targeting of the interleukin-6 receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

The pro- and anti-inflammatory properties of the cytokine interleukin-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Rapid histochemistry using slow off-rate modified aptamers with anionic competition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Aptamer-based multiplexed proteomic technology for biomarker discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Tocilizumab for rheumatoid arthritis: a Cochrane systematic review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Averting inflammation by targeting the cytokine environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

IL-6: from its discovery to clinical applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Interleukin-6 in bone metastasis and cancer progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Expanding the chemistry of DNA for in vitro selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Discovery and development of therapeutic aptamers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Interleukin-6: a new therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Interleukin-6: from basic science to medicine--40 years in immunology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

A road map for those who don't know JAK-STAT

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Anti-interleukin 6 receptor antibody treatment in rheumatic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Anti-L-selectin aptamers: binding characteristics, pharmacokinetic parameters, and activity against an intravascular target in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Post-SELEX combinatorial optimization of aptamers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Stability, specific binding activity, and plasma concentration in mice of an oligodeoxynucleotide modified at 5'-terminal with poly(ethylene glycol).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Soluble cytokine receptors are present in normal human urine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

In vitro selection of RNA molecules that bind specific ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

6 September 2017

Nucleoside conformation is determined by the electronegativity of the sugar substituent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

14 September 2017

The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: results from a multinational, phase IIb, randomized, double-blind, placebo/active-controlled, d

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

27 September 2017

1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

23 June 2018

Human soluble IL-6 receptor: its detection and enhanced release by HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

23 June 2018

Aptamers as therapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

31 August 2018

Pegaptanib for neovascular age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3961692

31 August 2018

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.532580

21 January 2018

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24415766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosensors for biomarkers in medical diagnostics

1 reference

https://pubmed.ncbi.nlm.nih.gov/24415766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24415766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits

1 reference

https://pubmed.ncbi.nlm.nih.gov/24415766

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.532580

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q38309810&oldid=1752955129"