(Q38313467)

2 September 2017

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title

The calcium sensing receptor: from calcium sensing to signaling (English)

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2 September 2017

Chen Zhang

1

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2 September 2017

Cassandra Lynn Miller

series ordinal

2

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2 September 2017

Edward M Brown

series ordinal

3

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2 September 2017

Jenny J Yang

series ordinal

4

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2 September 2017

10 January 2015

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Science in China. Series C: Life Sciences

2 September 2017

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2 September 2017

58

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2 September 2017

1

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2 September 2017

14-27

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https://scigraph.springernature.com/pub.10.1007/s11427-014-4779-y

2 September 2017

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cites work

Calcium acts as a first messenger through the calcium-sensing receptor in the cardiovascular system

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https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia

21 January 2018

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Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis

21 January 2018

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Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium-sensing receptor modulates cell adhesion and migration via integrins

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Divalent cations modulate the activity of metabotropic glutamate receptors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Glutamate‐mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium sensing properties of the GABA(B) receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Decoding cytosolic Ca2+ oscillations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The extracellular Ca2+-sensing receptor: central mediator of systemic calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Cloning and characterization of a calcium-sensing receptor from the hypercalcemic New Zealand white rabbit reveals unaltered responsiveness to extracellular calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Mechanism of action of the calcium-sensing receptor in human antral gastrin cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium-dependent c-myc proto-oncogene expression and proliferation of Caco-2 cells: a role for a luminal extracellular calcium-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2+o)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium-sensing receptor in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Heterodimerization of calcium sensing receptors with metabotropic glutamate receptors in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

A subthreshold persistent sodium current mediates bursting in rat subfornical organ neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Cao-sensing receptor (CaR)-mediated activation of K+ channels is blunted in CaR gene-deficient mouse neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Deficient cation channel regulation in neurons from mice with targeted disruption of the extracellular Ca2+-sensing receptor gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium and polyamine regulated calcium-sensing receptors in cardiac tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Involvement of calcium-sensing receptor in cardiac hypertrophy-induced by angiotensinII through calcineurin pathway in cultured neonatal rat cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Extracellular calcium sensing and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium receptor-mediated intracellular signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization. Implications for function of monomeric Ca(2+) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Dimerization of the calcium-sensing receptor occurs within the extracellular domain and is eliminated by Cys --> Ser mutations at Cys101 and Cys236.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Human Ca2+ receptor cysteine-rich domain. Analysis of function of mutant and chimeric receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Signaling of the human calcium-sensing receptor expressed in HEK293-cells is modulated by protein kinases A and C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium sensing receptor mutations implicated in pancreatitis and idiopathic epilepsy syndrome disrupt an arginine-rich retention motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Delineating a Ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Identification of acidic residues in the extracellular loops of the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ and a positive allosteric modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Physiological significance of L-amino acid sensing by extracellular Ca(2+)-sensing receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

L-amino acid sensing by the extracellular Ca2+-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium sensing receptors and calcium oscillations: calcium as a first messenger

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

L-amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca(2+) sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Intravenous infusion of L-isomers of phenylalanine and tryptophan stimulate gastric acid secretion at physiologic plasma concentrations in normal subjects and after parietal cell vagotomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Silencing of filamin A gene expression inhibits Ca2+ -sensing receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

High affinity interaction with filamin A protects against calcium-sensing receptor degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

AMSH is an endosome-associated ubiquitin isopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

AMSH regulates calcium-sensing receptor signaling through direct interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Beta-arrestins and cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

RAMPs: 5 years on, where to now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

β-Arrestin-mediated receptor trafficking and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Cellular mechanisms of membrane protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Targeting of G protein-coupled receptors to the plasma membrane in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Sar1-dependent trafficking of the human calcium receptor to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Rab1 small GTP-binding protein regulates cell surface trafficking of the human calcium-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The p24 family and selective transport processes at the ER-Golgi interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor-mediated Rho kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium sensing receptor forms complex with and is up-regulated by caveolin-1 in cultured human osteosarcoma (Saos-2) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

m-Calpain colocalizes with the calcium-sensing receptor (CaR) in caveolae in parathyroid cells and participates in degradation of the CaR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Functional desensitization of the extracellular calcium-sensing receptor is regulated via distinct mechanisms: role of G protein-coupled receptor kinases, protein kinase C and beta-arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Large putative PEST-like sequence motif at the carboxyl tail of human calcium receptor directs lysosomal degradation and regulates cell surface receptor level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Regulation of GPCRs by endocytic membrane trafficking and its potential implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Regulation of receptor trafficking by GRKs and arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Diseases associated with the extracellular calcium-sensing receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Activating autoantibodies against the calcium-sensing receptor detected in two patients with autoimmune polyendocrine syndrome type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Mapping of human autoantibody binding sites on the calcium-sensing receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Novel mutations in the calcium-sensing receptor gene associated with biochemical and functional differences in familial hypocalciuric hypercalcaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Association between activating mutations of calcium-sensing receptor and Bartter's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Mutational analysis of the adaptor protein 2 sigma subunit (AP2S1) gene: search for autosomal dominant hypocalcemia type 3 (ADH3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

Amino-acid-type selective isotope labeling of proteins expressed in Baculovirus-infected insect cells useful for NMR studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-014-4779-Y

10.1007/S11427-014-4779-Y

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

2 September 2017

0 references

1 reference