(Q38327548)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

title

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

ubiquitin-proteasome system

23 January 2020

main subject

0 references

author

Chan, H.Y.E.

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Kwok-Fai Lau

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

author name string

Wan Ning Vanessa Chow

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Hon Wing Luk

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

language of work or name

English

0 references

publication date

1 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

volume

443

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

page(s)

681-689

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

23 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

The hunt for huntingtin function: interaction partners tell many different stories

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Molecular mechanisms and potential therapeutical targets in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Acetylation targets mutant huntingtin to autophagosomes for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

The FE65 proteins and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Functions of WW domains in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

A dominant role for FE65 (APBB1) in nuclear signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Expression of the Fe65 adapter protein in adult and developing mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Sodium dodecyl sulfate-insoluble oligomers are involved in polyglutamine degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Fly models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Huntingtin-protein interactions and the pathogenesis of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Structural basis for polyproline recognition by the FE65 WW domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20112175

21 January 2018

Identifiers

DOI

10.1042/BJ20112175

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22352297%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference