(Q38329782)

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Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1.

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Europe PubMed Central

PMC publication ID

2 September 2017

Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1. (English)

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

0 references

C3G guanyl-nucleotide exchange factor Dmel_CG42328

1 reference

GOA release 2020-03-11

author name string

Ishimaru S

1

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Williams R

2

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Clark E

3

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Hanafusa H

4

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Gaul U

5

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Europe PubMed Central

PMC publication ID

2 September 2017

language of work or name

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publication date

1 January 1999

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Europe PubMed Central

PMC publication ID

2 September 2017

The EMBO Journal

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Europe PubMed Central

PMC publication ID

2 September 2017

18

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

1

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

145-155

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

1 reference

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Expressed sequence tags--ESTablishing bridges between genomes

1 reference

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Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases

1 reference

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Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development

1 reference

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Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G.

1 reference

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cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

1 reference

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SH2 and SH3-containing adaptor proteins: redundant or independent mediators of intracellular signal transduction.

1 reference

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v-Crk-induced cell transformation: changes in focal adhesion composition and signaling

1 reference

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A screen for genes that function downstream of Ras1 during Drosophila eye development.

1 reference

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DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

1 reference

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Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

1 reference

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KSR, a novel protein kinase required for RAS signal transduction

1 reference

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

1 reference

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1 reference

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Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins

1 reference

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Myristylation and palmitylation of Src family members: the fats of the matter

1 reference

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6 September 2017

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1 reference

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6 September 2017

Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein.

1 reference

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Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

1 reference

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1 reference

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1 reference

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

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Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins

1 reference

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Integrins and signal transduction pathways: the road taken

1 reference

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v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1 reference

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A Drosophila shc Gene Product Is Implicated in Signaling by the DER Receptor Tyrosine Kinase

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C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

1 reference

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

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A ras-related gene with transformation suppressor activity

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Two species of human CRK cDNA encode proteins with distinct biological activities

1 reference

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Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine-dependent interactions in vitro

1 reference

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brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2

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Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 Cells Induces DNA Synthesis and Morphological Changes

1 reference

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DNA sequencing with chain-terminating inhibitors

1 reference

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

1 reference

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1 reference

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Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1 reference

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JNK signaling and morphogenesis in Drosophila.

1 reference

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Regulation and function of the JNK subgroup of MAP kinases

1 reference

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Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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Activation of R-Ras by Ras-guanine nucleotide-releasing factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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A role for Ras in v-Crk transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

23 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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1 reference

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1 reference

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A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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Raf functions downstream of Ras1 in the Sevenless signal transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

23 June 2018

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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Cell fate in the Drosophila ommatidium

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

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MAP kinase in situ activation atlas during Drosophila embryogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

31 August 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

31 August 2018

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

31 August 2018

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

31 August 2018

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

31 August 2018

dpp induces mesodermal gene expression in Drosophila.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171110

31 August 2018

Analysis of P transposable element functions in drosophila

1 reference

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12 December 2020

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10.1093/EMBOJ/18.1.145

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

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