(Q38330818)

1 July 2019

title

Polycomb repressor complex-2 is a novel target for mesothelioma therapy (English)

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1 July 2019

author name string

Clinton D Kemp

1

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1 July 2019

Mahadev Rao

2

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1 July 2019

Sichuan Xi

3

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1 July 2019

Suzanne Inchauste

4

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1 July 2019

Haresh Mani

5

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1 July 2019

Patricia Fetsch

6

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1 July 2019

Armando Filie

7

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1 July 2019

Mary Zhang

8

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1 July 2019

Julie A Hong

9

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1 July 2019

Robert L Walker

10

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1 July 2019

Yuelin J Zhu

11

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1 July 2019

R Taylor Ripley

12

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1 July 2019

Aarti Mathur

13

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1 July 2019

Fang Liu

14

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1 July 2019

Maocheng Yang

15

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1 July 2019

Paul A Meltzer

16

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1 July 2019

Victor E Marquez

17

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1 July 2019

Assunta De Rienzo

18

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1 July 2019

Raphael Bueno

19

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1 July 2019

David S Schrump

20

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1 July 2019

language of work or name

English

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publication date

25 October 2011

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1 July 2019

published in

Clinical Cancer Research

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1 July 2019

volume

18

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1 July 2019

issue

1

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1 July 2019

page(s)

77-90

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1 July 2019

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

cites work

1 reference

12 December 2020

Activated p53 suppresses the histone methyltransferase EZH2 gene

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12 December 2020

Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection.

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12 December 2020

The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation

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12 December 2020

The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation

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12 December 2020

Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer

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12 December 2020

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

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12 December 2020

Control of developmental regulators by Polycomb in human embryonic stem cells

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12 December 2020

Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.

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12 December 2020

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

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12 December 2020

Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation

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12 December 2020

Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma

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12 December 2020

Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids

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12 December 2020

Synergy of Eed and Tsix in the repression of Xist gene and X-chromosome inactivation

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12 December 2020

Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors

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12 December 2020

Genomic events associated with progression of pleural malignant mesothelioma

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12 December 2020

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

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12 December 2020

Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1

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12 December 2020

Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome

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12 December 2020

The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

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12 December 2020

Asbestos-induced lung diseases: an update

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12 December 2020

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

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12 December 2020

Molecular biology of malignant mesothelioma

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12 December 2020

Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.

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12 December 2020

High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy

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12 December 2020

EZH2 is essential for glioblastoma cancer stem cell maintenance

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12 December 2020

WD40 repeats arrange histone tails for spreading of silencing

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12 December 2020

hsa-miR-29c* is linked to the prognosis of malignant pleural mesothelioma.

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12 December 2020

Polycomb group protein-mediated repression of transcription

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12 December 2020

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination

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12 December 2020

Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors

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12 December 2020

Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance

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12 December 2020

ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency

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12 December 2020

Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma

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12 December 2020

Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer

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12 December 2020

Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

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12 December 2020

Epigenetic control of embryonic stem cell fate

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12 December 2020

Cigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells

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12 December 2020

Interpretation of developmental signaling at chromatin: the Polycomb perspective

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12 December 2020

CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells

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12 December 2020

MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2

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12 December 2020

Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2.

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12 December 2020

HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression

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12 December 2020

Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma

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12 December 2020

EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression

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12 December 2020

The evolution of multimodality therapy for malignant pleural mesothelioma

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12 December 2020

Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer

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12 December 2020

Regulation of the cytoskeleton in mesothelial cells: Reversible loss of keratin and increase in vimentin during rapid growth in culture

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12 December 2020

10.1158/1078-0432.CCR-11-0962

Identifiers

DOI

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1 July 2019

PMCID

6310139

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1 July 2019

PubMed ID

22028491

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1 July 2019