(Q38336728)

2 September 2017

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title

The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation (English)

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2 September 2017

Player MR

1

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PubMed ID

9623881

2 September 2017

Torrence PF

series ordinal

2

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2 September 2017

1 May 1998

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Pharmacology & Therapeutics

2 September 2017

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2 September 2017

78

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2 September 2017

55-113

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2 September 2017

2

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Ability of insulin and DsRNA to induce interferon system and Hsp 70 in fibroblast and epithelial cells in relation to their effects on cell growth

2 September 2017

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12 December 2020

8-Azido double-stranded RNA photoaffinity probes. Enzymatic synthesis, characterization, and biological properties of poly(I,8-azidoI).poly(C) and poly(I,8-azidoI).poly(C12U) with 2',5'-oligoadenylate synthetase and protein kinase

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12 December 2020

Only one 3'-hydroxyl group of ppp5' A2'p5'A2'p5' A (2-5A) is required for activation of the 2-5A-dependent endonuclease.

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12 December 2020

The synergistic cytocidal effect produced by immune interferon and tumor necrosis factor in HT-29 cells is associated with inhibition of rRNA processing and (2',5') oligo (A) activation of RNase L.

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12 December 2020

Synthesis and properties of a modified 2'-5'-adenylate trimer containing 2'-terminal 8-bromoadenosine

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12 December 2020

Hepatitis delta virus replication in vitro is not affected by interferon-alpha or -gamma despite intact cellular responses to interferon and dsRNA.

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12 December 2020

Increased toxicity of double-stranded ribonucleic acid in virus-infected animals.

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12 December 2020

Synthesis, characterization and properties of ppp(A2'p)nApCp and related high-specific-activity 32P-labelled derivatives of ppp(A2'p)nA

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12 December 2020

Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-sRNA synthetase

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12 December 2020

Synthesis of 2'5'-oligo(A) in extracts of interferon-treated HeLa cells

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12 December 2020

Chemical modification potentiates the biological activities of 2-5A and its congeners.

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12 December 2020

An efficient chemical synthesis of adenylyl(2' goes to 5')adenylyl(2' goes to 5')adenosine [(2'-5')-oligo(A)]

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12 December 2020

Isolation of a virus from the pancreas of a child with diabetic ketoacidosis

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12 December 2020

2',5'-oligoadenylates inhibit relaxation of supercoiled DNA by calf thymus DNA topoisomerase I.

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12 December 2020

Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25

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12 December 2020

Cyclic AMP-dependent regulation of activities of synthetase and phosphodiesterase of 2',5'-oligoadenylate in NIH 3T3 cells.

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12 December 2020

Structural requirements of double-stranded RNA for the activation of 2‘,5‘-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells

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12 December 2020

Principles and background for the construction of transgenic plants displaying multiple virus resistance.

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12 December 2020

Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor

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12 December 2020

Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs in human cells.

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12 December 2020

Induction of interferon-beta and 2',5'-oligoadenylate synthetase mRNAs by interleukin 6 during differentiation of murine myeloid cells

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12 December 2020

Biological activities of phosphodiester linkage isomers of 2-5A.

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12 December 2020

Enhanced level of double-stranded RNA-dependent protein kinase in peripheral blood mononuclear cells of patients with viral infections

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12 December 2020

2'5'-adenylate inhibition of erythropoietin-dependent colony formation

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12 December 2020

Indomethacin enhances serum 2'5'-oligoadenylate synthetase in patients with hepatitis B and C virus chronic active hepatitis.

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12 December 2020

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

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12 December 2020

Activation of ribonuclease L by (2'-5')(A)4-poly(L-lysine) conjugates in intact cells.

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12 December 2020

Virus-mediated inhibition of the ppp(A2′p)n A system and its prevention by interferon

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12 December 2020

Early Chemical Evolution of Nucleic Acids: A Theoretical Model

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12 December 2020

Interferon, double-stranded RNA and RNA degradation. Fractionation of the endonucleaseINT system into two macromolecular components; role of a small molecule in nuclease activation

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12 December 2020

Chromosome 1 Charcot-Marie-Tooth disease (CMT1B) locus in the Fc? receptor gene region

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12 December 2020

Synthesis of (2'-5')oligoadenylate and activation of an endoribonuclease in interferon-treated HeLa cells infected with reovirus

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12 December 2020

Inhibition of the RNA polymerase of vesicular stomatitis virus by ppp5'A2'p5'A and related compounds

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12 December 2020

Induction of ppp(A2'p)nA-dependent RNase in murine JLS-V9R cells during growth inhibition

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12 December 2020

Regulation of HIV gene expression by RNA-protein interactions

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12 December 2020

Oligo-2',5'-adenylate synthetase activity in cells persistently infected with human T-lymphotropic virus type I (HTLV-I).

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12 December 2020

Comparison of (2′-5′) Oligo-adenylate Synthetase and Interferon Blood-Levels in Mice Early After Viral Infection

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12 December 2020

Mechanism of interferon action Species specificity of interferon and of the interferon-mediated inhibitor of translation from mouse, monkey, and human cells

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12 December 2020

Fractionation and Characterization of 2',5'-O1igoadenylates by Polyaecrylamide Gel Electrophoresis: An Alternative Method for Assaying 2',5'-O1igoadenylate Synthetase

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12 December 2020

Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase.

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12 December 2020

Metabolic stability of 2′ 5′oligo (A) and activity of 2′ 5′oligo (A)-dependent endonuclease in extracts of interferon-treated and control HeLa cells

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12 December 2020

Conformational analysis of brominated pA2'-5'A2'-5'A analogs. An NMR and model-building study

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12 December 2020

Early events in signalling by interferons.

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12 December 2020

Dual Action of Double-Stranded RNA in Inhibiting Protein Synthesis in Extracts of Interferon-Treated Mouse L Cells. Translation is Impaired at the Level of Initiation and by mRNA Degradation

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12 December 2020

Effect of temperature on ppp(A2'p)nA binding protein activities in rabbit reticulocyte lysates and other mammalian extracts

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12 December 2020

Truncation does not abrogate transcriptional downregulation of the c-myc gene by sodium butyrate in Burkitt's lymphoma cells

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12 December 2020

The epidermal growth factor- and interferon-independent effects of double-stranded RNA in A431 cells

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12 December 2020

The respective roles of the protein kinase and pppA2' p5' A2' p5 A-activated endonuclease in the inhibition of protein synthesis by double stranded RNA in rabbit reticulocyte lysates

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12 December 2020

Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine

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12 December 2020

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells

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12 December 2020

Posttranscriptional regulation of c-myc proto-oncogene expression and growth inhibition by recombinant human interferon-beta ser17 in a human colon carcinoma cell line

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12 December 2020

2',5'-Oligoadenylates and related 2',5'-oligonucleotide analogues. 1. Substrate specificity of the interferon-induced murine 2',5'-oligoadenylate synthetase and enzymatic synthesis of oligomers

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12 December 2020

Inhibition of DNA topoisomerase I activity by 2',5'-oligoadenylates and mismatched double-stranded RNA in uninfected and HIV-1-infected H9 cells

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12 December 2020

Conformational analysis of the nucleotides A2'-5'A, A2'-5'A2'-5'A and A2'-5'U from nuclear magnetic resonance and circular dichroism studies

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12 December 2020

Conformational studies of (2'-5') polynucleotides: theoretical computations of energy, base morphology, helical structure, and duplex formation

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12 December 2020

2-5A synthetase: assay, distribution and variation with growth or hormone status

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12 December 2020

Stoichiometry of 2',5'-oligoadenylate-induced dimerization of ribonuclease L. A sedimentation equilibrium study

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12 December 2020

Basal and interferon-induced 2',5'-oligoadenylate synthetase in human monocytes, lymphocytes, and peritoneal macrophages

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12 December 2020

Antiviral effects of 2',5'oligoadenylates (2-5As), and related compounds

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12 December 2020

Homologies between different forms of 2-5A synthetases

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12 December 2020

Interleukin-6 induces the (2'-5') oligoadenylate synthetase gene in M1 cells through an effect on the interferon-responsive enhancer

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12 December 2020

Phase I trial of an oral immunomodulator and interferon inducer in cancer patients.

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12 December 2020

Distribution of the ppp(A2′p)nA-binding protein and interferon-related enzymes in animals, plants, and lower organisms

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12 December 2020

Terminal differentiation of myeloleukemic M1 cells induced by IL-6: role of endogenous interferon

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12 December 2020

Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process

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12 December 2020

Chromosome anomalies in human breast cancer: evidence for specific involvement of 1q region in lymphocyte cultures

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12 December 2020

2'5'-linked polynucleotides do form a double-stranded helical structure: a result from the energy minimization study of A2'p5'A

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12 December 2020

Immunological evidence for the in vivo occurrence of (2'-5')adenylyladenosine oligonucleotides in eukaryotes and prokaryotes

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12 December 2020

Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells

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12 December 2020

Possible involvement of (2'5')oligoadenylate synthetase activity in pre-mRNA splicing

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12 December 2020

Interferon-induced expression of different genes is mediated by distinct regulatory pathways

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12 December 2020

Association of 2'-5' oligoribonucleotides

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12 December 2020

Variation of (2'-5')oligo(adenylate) synthetase activity during rat-liver regeneration

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12 December 2020

(2'-5')Oligoadenylate in rat liver: modulation after partial hepatectomy

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12 December 2020

2',5'-Oligoadenylate-dependent RNAse located in nuclei: biochemical characterization and subcellular distribution of the nuclease in human and murine cells

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12 December 2020

Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome

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12 December 2020

Correlation between the antiviral effect of interferon treatment and the inhibition of in vitro mRNA translation in noninfected L cells

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12 December 2020

Antiviral activity in L1210 cells of liposome-encapsulated (2'-5')oligo(adenylate) analogues

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12 December 2020

Hydrolytic stability of helical RNA: a selective advantage for the natural 3',5'-bond

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12 December 2020

3' end structure of the human (2'-5') oligo A synthetase gene: prediction of two distinct proteins with cell type-specific expression

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12 December 2020

Cortisol induces (2'-5')oligoadenylate synthetase in cultured chick embryo tendon fibroblasts

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12 December 2020

Growth regulation of A431 cells. Modulation of expression of transforming growth factor-alpha mRNA and 2',5'-oligoadenylate synthetase activity

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12 December 2020

Frequent loss of heterozygosity on chromosomes 1q, 5q, and 17p in human gastric carcinomas.

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12 December 2020

Reversibility of the antiproliferative effect of interferon.

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12 December 2020

A conformational study of adenylyl-(3', 5')-adenosine and adenylyl-(2', 5')-adenosine in aqueous solution by carbon-13 magnetic resonance spectroscopy

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12 December 2020

Effect of interferon pretreatment on coupled transcription and translation in cell-free extracts of primary chick embryo cells

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12 December 2020

Action of quail and chicken interferons on a quail cell line, QT35.

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12 December 2020

Induction and Maintenance of 2′,5′-Oligoadenylate Synthetase in Interferon-Treated Chicken Embryo Cells

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12 December 2020

Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies

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12 December 2020

Spectrophotometric pyrophosphate assay of 2',5'-oligoadenylate synthetase

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12 December 2020

Increased IFN-alpha-induced sensitivity but reduced reactivity of 2',5'-oligoadenylate synthetase (2,5AS) in trisomy 21 blood lymphocytes.

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12 December 2020

Conformational analysis of the trinucleoside diphosphate 3'd(A2'-5'A2'-5'A). An NMR and CD study

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12 December 2020

Synthesis and characterization of (2′-5′)ppp3′dA(p3′dA)n, an analogue of (2′-5′)pppA(pA)n

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12 December 2020

Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon

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12 December 2020

Mechanism for discrimination between viral and host mRNA in interferon-treated cells

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12 December 2020

Oligo(2'-5')adenylate synthetase in human lymphoblastoid cells.

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12 December 2020

HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes.

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12 December 2020

Interferon-induced revertants of ras-transformed cells: resistance to transformation by specific oncogenes and retransformation by 5-azacytidine

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12 December 2020

Release of the inhibition of messenger RNA translation in extracts of interferon-treated Ehrlich ascites tumor cells by added transfer RNA.

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12 December 2020

Constitutive expression of (2'-5') oligo A synthetase confers resistance to picornavirus infection.

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12 December 2020

Induction of 2'-5' oligoadenylate synthetase and activation of ribonuclease in tamoxifen treated human breast cancer cell lines

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12 December 2020

Constitutive expression of a 2',5'-oligoadenylate synthetase cDNA results in increased antiviral activity and growth suppression

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12 December 2020

Differential activity of the 30-kD and the 100-kD forms of 2'-5'An synthetase induced by recombinant human interferon-alpha and interferon-gamma

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12 December 2020

(2'-5') oligoadenylate synthetase in chicken embryo erythrocytes and immature red blood cells

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12 December 2020

Different mechanisms for activation of gene transcription by interferons alpha and gamma

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12 December 2020

Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor

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12 December 2020

Effects of rubella virus infection on islet function

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12 December 2020

The sequential change of serum 2',5' oligoadenylate synthetase in different infectious patterns of duck hepatitis B virus in ducks in experimental transmission

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12 December 2020

Reduced steady-state levels of vaccinia virus-specific early mRNAs in interferon-treated chick embryo fibroblasts

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12 December 2020

Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis

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12 December 2020

Analogue inhibitor of 2-5A action: effect on the interferon-mediated inhibition of encephalomyocarditis virus replication

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12 December 2020

A Ca2+ release mechanism gated by the novel pyridine nucleotide, NAADP.

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12 December 2020

The 2′5′ oligoadenylate synthetase has a multifunctional 2′5′ nucleotidyl-transferase activity

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12 December 2020

Induction of 2',5'-oligoadenylate synthetase and blast transformation in primary chronic lymphocytic leukemia cells following exposure to interferon in vitro.

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12 December 2020

The 2'-5' adenylate (2-5A) system in erythropoiesis

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12 December 2020

Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells

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12 December 2020

Analysis of (2'-5')-oligo(A) and related oligonucleotides by high-performance liquid chromatography

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12 December 2020

An improved method for purifying 2',5'-oligoadenylate synthetases

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12 December 2020

(2'-5')Oligoadenylate synthetase in pig spleen: isolation and characterization

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12 December 2020

Biological and clinical effects of the combination of beta- and gamma-interferons administered as a 5-day continuous infusion

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12 December 2020

2‘,5‘-Oligoadenylate synthetase activity in lymphocytes from normal mouse

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12 December 2020

Polyclonal antibodies against RNase L. Subcellular localization of this enzyme in mouse cells

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12 December 2020

Interferon Action: RNA Cleavage Pattern of a (2′-5′)Oligoadenylate—Dependent Endonuclease

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12 December 2020

Synthesis and properties of 5′-triphosphoryl 2′-5′ oligoadenylates (2-5A), and a general method for synthesis of 3′, 5′-bisphosphorylated oligonucleotides

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12 December 2020

Role of 2'-5'-oligoadenylate synthetase in gamma-interferon-mediated growth inhibition of A431 cells

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12 December 2020

Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex

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12 December 2020

Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2',5'-oligoadenylate synthetase

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12 December 2020

An early event in the interferon-induced transmembrane signaling process

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12 December 2020

A conserved double-stranded RNA-binding domain

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12 December 2020

Independent regulation of ppp(A2'p)nA-dependent RNase in NIH 3T3, clone 1 cells by growth arrest and interferon treatment

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12 December 2020

Stereoconfiguration markedly affects the biochemical and biological properties of phosphorothioate analogs of 2-5A core, (A2'p5')2A

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12 December 2020

Translation of RNA by L cell extracts: Effect of interferon

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12 December 2020

8-Methyladenosine-substituted analogues of 2-5A: synthesis and their biological activities

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12 December 2020

Effects of IFN-beta on growth of human prostatic JCA-1 cells

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12 December 2020

Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure

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12 December 2020

Identification of the ATP binding domain of recombinant human 40-kDa 2',5'-oligoadenylate synthetase by photoaffinity labeling with 8-azido-[alpha-32P]ATP.

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12 December 2020

Synthesis of 2'-end-modified 2'-5'-oligoadenylates

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12 December 2020

Occurrence of 2-5A and RNA degradation in the chick oviduct during rapid estrogen withdrawal

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12 December 2020

A (2'-5')An-dependent endonuclease: tissue distribution in BALB/c mice and the effects of IFN-beta treatment and anti-IFN-alpha/beta immunoglobulin on the levels of the enzyme

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12 December 2020

Maintenance of protein synthesis in spite of mRNA breakdown in interferon-treated HeLa cells infected with reovirus

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12 December 2020

Oligonucleotide interactions. IV. Conformational differences between deoxy- and ribodinucleoside phosphates

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12 December 2020

Induction of the 2-5A system by interferon and transmissible gastroenteritis virus

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12 December 2020

Enzyme immunoassay of 2'-5'-oligoadenylates at the femtomole level.

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12 December 2020

Cloned human interferons alpha: differential affinities for polyinosinic acid and relationship between molecular structure and species specificity

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12 December 2020

Activation of the interferon system during myogenesis in vitro

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12 December 2020

Characterization of two murine (2'-5')(A)n-dependent endonucleases of different molecular mass

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12 December 2020

Cultured human endothelial cells treated with recombinant leukocyte A interferon. Tubuloreticular inclusion formation, antiproliferative effect, and 2',5' oligoadenylate synthetase induction

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12 December 2020

The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains

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12 December 2020

Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under field conditions

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12 December 2020

Synthesis and biological activity of a fluorescent analogue of 2-5A

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12 December 2020

Specific regulation of the 100 kDa 2-5 A synthetase by protein kinase C

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12 December 2020

Antiviral response and induction of specific proteins in cells treated with immune T (type II) interferon analogous to that from viral interferon (type I)-treated cells

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12 December 2020

Functional analysis of 2-5A-dependent RNase and 2-5a using 2',5'-oligoadenylate-cellulose.

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12 December 2020

Abnormal behavior of interferon-induced enzymatic activities in an interferon-resistant cell line

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12 December 2020

Analogues and analogue inhibitors of ppp(A2'p)nA. Their stability and biological activity

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12 December 2020

Selective inhibition of viral protein accumulation in interferon-treated cells; nondiscriminate inhibition of the translation of added viral and cellular messenger RNAs in their extracts

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12 December 2020

Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells

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12 December 2020

2‘,5‘-Oligo(A)-activated endoribonuclease. Tissue distribution and characterization with a binding assay

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12 December 2020

Double-stranded RNA and interferon action

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12 December 2020

A functional protein kinase C is required for induction of 2-5A synthetase by recombinant interferon-alpha A in Daudi cells.

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12 December 2020

Interferon production in patients infected with HIV-1

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12 December 2020

Hormonal and immunological regulation of 2', 5'-oligoadenylate synthetase activity in human peripheral blood mononuclear cells

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12 December 2020

On the biosynthesis and structure of double-stranded RNA in vaccinia virus-infected cells

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12 December 2020

Autocrine beta-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation

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12 December 2020

Isoforms p69 and p100 of 2',5'-oligoadenylate synthetase induced differentially by interferons in vivo and in vitro

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12 December 2020

Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease.

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12 December 2020

The (2'-5')oligoadenylate synthetase is present in the lowest multicellular organisms, the marine sponges. Demonstration of the existence and identification of its reaction products

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12 December 2020

Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome

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12 December 2020

2- and 8-azido photoaffinity probes. 1. Enzymatic synthesis, characterization, and biological properties of 2- and 8-azido photoprobes of 2-5A and photolabeling of 2-5A binding proteins

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12 December 2020

A bipartite model of 2-5A-dependent RNase L

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12 December 2020

Ribosomal RNA cleavage, nuclease activation and 2-5A (ppp(A2′p)nA) in interferon-treated cells

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12 December 2020

Rapid reduction of mRNA coding for 2'-5'-oligoadenylate synthetase in rat pheochromocytoma PC12 cells during apoptosis.

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12 December 2020

rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells

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12 December 2020

The interferon-induced enzyme oligo-isoadenylate synthetase: Rapid determination of its in vitro products

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12 December 2020

Pharmacokinetic study of a human recombinant interferon (Re-IFN-alpha A) in cynomolgus monkeys by 2'-5' oligoadenylate synthetase assay

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12 December 2020

Interferon action may be mediated by activation of a nuclease by pppA2′p5′A2′p5′A

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12 December 2020

Comparative spectroscopic, calorimetric, and computational studies of nucleic acid complexes with 2',5"-versus 3',5"-phosphodiester linkages

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12 December 2020

Inhibition of Protein Synthesis in Cell-Free Systems from Interferon-Treated, Infected Cells: Further Characterization and Effect of Formylmethionyl-tRNA(F)

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12 December 2020

Effect of interferon and 2',5'-oligoadenylates on rotavirus RNA synthesis.

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12 December 2020

Structural requirements of (2'-5') oligoadenylate for protein synthesis inhibition in human fibroblasts

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12 December 2020

Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism

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12 December 2020

Raman spectroscopy of interferon-induced 2',5'-linked oligoadenylates

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12 December 2020

Slowed Transcription and Rapid Messenger RNA Turnover Contribute to a Decline in Synthesis of Ovine Trophoblast Protein-i during in Vitro Culture1

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12 December 2020

Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells

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12 December 2020

Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells

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12 December 2020

pppA2'p5A' blocks vesicular stomatitis virus replication in intact cells

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12 December 2020

Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections

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12 December 2020

Increased endonuclease activity in an extract from mouse Ehrlich ascites tumor cells which had been treated with a partially purified interferon preparation: Dependence on double-stranded RNA

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12 December 2020

Mode of action of the anti-AIDS compound poly(I).poly(C12U) (Ampligen): activator of 2',5'-oligoadenylate synthetase and double-stranded RNA-dependent kinase

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12 December 2020

On the origin of RNA splicing and introns

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12 December 2020

Genetically determined target organ susceptibility in the pathogenesis of spontaneous autoimmune thyroiditis: aberrant expression of MHC-class II antigens and the possible role of virus

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12 December 2020

Sensitive radioimmuno assay for 2',5'-oligoadenylates using a novel 125I-labeled derivative of 2',5'-triadenylate 5'-triphosphate

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12 December 2020

Interferon, double-stranded RNA, and RNA degradation. Isolation of homogeneous pppA(2'p5'A)n-1 synthetase from Ehrlich ascites tumor cells

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12 December 2020

Suppressive effect of interferon on erythroid cell proliferation

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12 December 2020

Methylxanthine treatment of rats reduces 2,5-oligoadenylate synthesis in liver nuclei

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12 December 2020

Induction of (2'-5') oligoadenylate synthetase activity during granulocyte and monocyte differentiation

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12 December 2020

Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon.

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12 December 2020

Ethanol induces 2',5'-oligoadenylate synthetase and antiviral activities through interferon-beta production

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12 December 2020

Growth regulation of melanoma cells by interferon and (2'-5')oligoadenylate synthetase

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12 December 2020

20 Interferon-induced enzymes: Microassays and their applications; purification and assay of (2′-5′)-oligoadenylate synthetase and assay of 2′-phosphodiesterase

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12 December 2020

The origin of the genetic code

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12 December 2020

Differential Effects of Two Interferon-Induced Translational Inhibitors on Initiation of Protein Synthesis

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12 December 2020

Synthesis, characterisation and biological significance of (2'-5')oligoadenylate derivatives of NAD+, ADP-ribose and adenosine(5')tetraphospho(5')adenosine

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12 December 2020

Presence of 2',5'-oligo(A) and of enzymes that synthesize, bind, and degrade 2',5'-oligo(A) in HeLa cell nuclei

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12 December 2020

2'5'Oligo(A) polymerase activity and inhibition of viral RNA synthesis in interferon-treated HeLa cells

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12 December 2020

The search for missing links between self-replicating nucleic acids and the RNA world

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12 December 2020

Phosphorylation of 2-5A core 5'-diphosphate to 2-5A in mouse L cell extracts

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12 December 2020

Mechanism of interferon action: Synthesis and activity of the interferon-mediated low-molecular-weight oligonucleotide from murine and human cells

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12 December 2020

Cleavage of nascent reovirus mRNA by localized activation of the 2'-5'-oligoadenylate-dependent endoribonuclease

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12 December 2020

The activity of 2,5-oligoadenylate synthetase, an interferon-induced enzyme, is coupled to the differentiation state of mouse condylar cartilage.

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12 December 2020

Clinical and in vitro antiproliferative properties of recombinant DNA-derived human interferon-alpha 2

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12 December 2020

Interferon-regulated human 2-5A synthetase gene maps to chromosome 12.

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12 December 2020

Replacement of the ribofuranose oxygen of 2-5A derivatives by methylene: synthesis of an aristeromycin analogue of 2-5A core 5'-monophosphate (5'-O-phosphoryladenylyl)(2'----5')adenyl(2'----5')adenosine

1 reference

12 December 2020

Purification and analysis of murine 2-5A-dependent RNase

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12 December 2020

Synthesis and biological activity of tubercidin analogues of ppp5'A2'p(5'A2'p)n5'A

1 reference

12 December 2020

Regulation of 2–5 A synthetase activity and antiviral state in interferon treated chick cells

1 reference

12 December 2020

Lack of Systematic Correlation between the Interferon Mediated Antiviral State and the Levels of 2-5A Synthetase and Protein Kinase in Three Different Types of Murine Cells

1 reference

12 December 2020

2',5' A synthetase: allosteric activation by fructose 1,6-bisphosphate

1 reference

12 December 2020

Development of the interferon system. I. In chicken cells development in ovo continues on time in vitro

1 reference

12 December 2020

Radioimmune, radiobinding and HPLC analysis of 2-5A and related oligonucleotides from intact cells

1 reference

12 December 2020

Purine 8-bromination modulates the ribonuclease L binding and activation abilities of 2',5'-oligoadenylates. Possible influence of glycosyl torsion angle

1 reference

12 December 2020

2',5'-Oligoadenylate synthetase expression is induced in response to heat shock

1 reference

12 December 2020

Mechanism of interferon action: inhibition of viral messenger ribonucleic acid translation in L-cell extracts

1 reference

12 December 2020

Signal transduction pathways in the induction of 2',5'-oligoadenylate synthetase gene expression by interferon alpha/beta

1 reference

12 December 2020

X-ray structure of a dinucleoside monophosphate A2'p5'C that contains a 2'-5' link found in (2'-5')oligo(A)s induced by interferons: single-stranded helical conformation of 2'-5'-linked oligonucleotides

1 reference

12 December 2020

Expression of antiviral activity and induction of 2',5'-oligoadenylate synthetase by conceptus secretory proteins enriched in bovine trophoblast protein-1

1 reference

12 December 2020

Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells

1 reference

12 December 2020

Interferon action. Covalent linkage of (2'-5')pppApApA(32P)pCp to (2'-5')(A)n-dependent ribonucleases in cell extracts by ultraviolet irradiation

1 reference

12 December 2020

Regulation of 2',5'-oligo(A) synthetase activity in theophylline-treated NIH 3T3 cells.

1 reference

12 December 2020

A role for interferons in early pregnancy

1 reference

12 December 2020

Oligonucleotide inhibitor of protein synthesis made in extracts of interferon-treated chick embryo cells: Comparison with the mouse low molecular weight inhibitor

1 reference

12 December 2020

Antiviral activity of tumour necrosis factor. Synergism with interferons and induction of oligo-2',5'-adenylate synthetase

1 reference

12 December 2020

Microwave exposure alters the expression of 2-5A-dependent RNase

1 reference

12 December 2020

A protein synthesizing system from interferon-treated cells that discriminates between cellular and viral messenger RNAs

1 reference

12 December 2020

RNA Catalysis Gives Fresh Perspective on the Origin of Life: The old chicken-and-egg problem of the origin of life is illuminated in unexpected ways by recent results on the splicing of RNA precursors

1 reference

12 December 2020

Absence of negative growth regulation in three new murine radiation-induced myeloid leukemia cell lines with deletion of chromosome 2

1 reference

12 December 2020

Molecular basis of interferon action: inhibition of viral RNA translation

1 reference

12 December 2020

Cellular RNA is not degraded in interferon-treated HeLa cells after poliovirus infection

1 reference

12 December 2020

Immunological cross-reactivity between large and small (2'-5')oligoadenylate synthetases from pig cells

1 reference

12 December 2020

Effect of endogenous and exogenous interferons on the differentiation of human monocyte cell line U937.

1 reference

12 December 2020

P1,P4-dithio-P2,P3-monochloromethylene diadenosine 5',5'''-P1,P4-tetraphosphate: a novel antiplatelet agent

1 reference

12 December 2020

RNA catalysis and the origin of life.

1 reference

12 December 2020

Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase

1 reference

12 December 2020

A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication

1 reference

12 December 2020

Affinity purification and characterization of (2'-5')oligo(adenylate)-dependent RNase from mouse spleen

1 reference

12 December 2020

Regulation of Gene Expression in the Chick Oviduct by Steroid Hormones

1 reference

12 December 2020

Regulation of poly(ADP-ribose) transferase activity by 2',5'-oligoadenylates

1 reference

12 December 2020

Coupled transcription and translation in mammalian and avian cell-free systems

1 reference

12 December 2020

Induction by vasoactive intestinal peptide of interferon alpha/beta synthesis in glial cells but not in neurons.

1 reference

12 December 2020

Age-dependent changes are observed in the levels of an enzyme mediator of interferon action: a (2'-5')A(n)-dependent endoribonuclease

1 reference

12 December 2020

Increased erythropoiesis and 2'5'-A polymerase activity in the marrow and spleen of phenylhydrazine-injected rats

1 reference

12 December 2020

Cellular and enzymatic activities of a synthetic heteropolymer double-stranded RNA of defined size

1 reference

12 December 2020

Induction, purification, and properties of 2'5' oligoadenylate synthetase

1 reference

12 December 2020

Significance of tubuloreticular inclusions in the pathobiology of human diseases

1 reference

12 December 2020

Chemical synthesis and biological characterization of phosphorothioate analogs of 2', 5'-3'-deoxyadenylate trimer

1 reference

12 December 2020

Synergistic effect of interferon-gamma and tumor necrosis factor-alpha on antiviral activity and (2'-5') oligo (A) synthetase induction in a myelomonocytic cell line

1 reference

12 December 2020

Are double-stranded RNA-directed inhibition of protein synthesis in interferon-treated cells and interferon induction related phenomena?

1 reference

12 December 2020

Structural requirements of polynucleotides for the activation of (2' - 5')An polymerase and protein kinase

1 reference

12 December 2020

The epidemiology of insulin dependent diabetes with particular reference to the relationship of virus infection to its etiology

1 reference

12 December 2020

The interferon system. A bird's eye view of its biochemistry

1 reference

12 December 2020

Epidermal growth factor-urogastrone action: induction of 2',5'-oligoadenylate synthetase activity and enhancement of the mitogenic effect by anti-interferon antibody

1 reference

12 December 2020

An interferon-induced phosphodiesterase degrading (2'-5') oligoisoadenylate and the C-C-A terminus of tRNA

1 reference

12 December 2020

Antagonism of 2-5 A-mediated inhibition of protein synthesis in intact cells by 2',5'-(pA)3.

1 reference

12 December 2020

Effect of cholestasis and bile acids on interferon-induced 2',5'-adenylate synthetase and NK cell activities.

1 reference

12 December 2020

Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatically synthesized 2',5'-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2',5'-oligoadenylate-dependent endoribonuclease

1 reference

12 December 2020

Activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells by 2'-O-methylated poly (inosinic acid) . poly(cytidylic acid), Correlations with interferon-inducing activity

1 reference

12 December 2020

Nerve growth factor induces changes in (2'-5')oligo(A) synthetase and 2'-phosphodiesterase activities during differentiation of PC12 pheochromocytoma cells

1 reference

12 December 2020

Facile and stereoselective synthesis of 2'-5'-oligothioadenylate by UO2(2+) ion catalyst

1 reference

12 December 2020

A misaligned double-stranded RNA, poly(I).poly(C12,U), induces accumulation of 2',5'-oligoadenylates in mouse tissues

1 reference

12 December 2020

Affinity Labelling and Characterization of the ppp(A2′p)nA-Dependent Endoribonuclease from Different Mammalian Sources

1 reference

12 December 2020

Increased 2,5-adenylate synthetase activity in the spleens of BALB/c mice during hypoxia-stimulated erythropoiesis

1 reference

12 December 2020

Interferon- and sarcolectin-dependent cellular regulatory interactions.

1 reference

12 December 2020

Analogs of (2‘-5‘)oligo(A). Endonuclease activation and inhibition of protein synthesis in intact cells

1 reference

12 December 2020

Uterine cellular changes in 2',5'-oligoadenylate synthetase during the bovine estrous cycle and early pregnancy

1 reference

12 December 2020

Induction of 2.5 OAS gene expression and activity is not sufficient for IFN-gamma-induced neuroblastoma cell differentiation.

1 reference

12 December 2020

Cordycepin analogues of 2-5A and its derivatives. Chemical synthesis and biological activity

1 reference

12 December 2020

The (2'-5')Oligoadenylate (pppA2'-5'A2'-5'A) Synthetase and Protein Kinase(s) from Interferon-Treated Cells

1 reference

12 December 2020

1 reference

12 December 2020

Comparison of pharmacokinetic behaviors of two human interferons (Lb-IFN-alpha and Re-IFN-alpha A) in cynomolgus monkeys by 2'-5' oligoadenylate synthetase assay

1 reference

12 December 2020

Inhibition of protein synthesis by double-stranded RNA in reticulocyte lysates: Evidence for activation of an endoribonuclease

1 reference

12 December 2020

Conformation analysis of 3'-fluorinated A(2'-5')A(2'-5')A fragments. Relation between conformation and biological activity.

1 reference

12 December 2020

2-5A-dependent RNase molecules dimerize during activation by 2-5A.

1 reference

12 December 2020

Paracrine activities of porcine trophoblastic interferons.

1 reference

12 December 2020

Regulation of Gene Expression in Chick Oviduct

1 reference

12 December 2020

Oligoribonucleotides containing 2',5'-phosphodiester linkages exhibit binding selectivity for 3',5'-RNA over 3',5'-ssDNA.

1 reference

12 December 2020

Radioimmune and radiobinding assays for A2'p5'A2'p5'A, pppA2'p5'A, and related oligonucleotides

1 reference

12 December 2020

Modulation of 2',5'-oligoadenylate synthetase in patients treated with alpha-interferon: effects of dose, schedule, and route of administration

1 reference

12 December 2020

Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera

1 reference

12 December 2020

Human lung cancer nodules in organotypic culture: no evidence of correlation between the antiproliferative effects of interferons and the induction of 2',5'-oligoadenylate synthetase.

1 reference

12 December 2020

RNase L and increased endoribonuclease activities in the mononuclear cells of patients with chronic myelogenous leukemia

1 reference

12 December 2020

Assay of (2'-5')-oligo(A) synthesized in vitro and the analysis of naturally occurring (2'-5')-oligo(A) from intact cells

1 reference

12 December 2020

Presence of 2'-5' a synthetase in dog liver

1 reference

12 December 2020

2′,5′-oligoadenylate synthetase gene expression in revertants of ras-transformed NIH3T3 fibroblasts

1 reference

12 December 2020

Induction of 2′5′-oligoadenylate synthetase activity and a new protein by chick interferon

1 reference

12 December 2020

A proliferation-related constraint on endogenous and interferon-induced 2-5A synthetase activity in normal and neoplastic Syrian hamster cells

1 reference

12 December 2020

Growth inhibition of human acute promyelocytic leukemia NB-4 cells by interferons and all-trans retinoic acid: trans-modulation of inducible gene expression pathways

1 reference

12 December 2020

Monoclonal antibodies to 5'-triphospho-(2'-5')adenyladenosine oligonucleotides

1 reference

12 December 2020

n-Decyl-NHpppA2'p5'A2'p5'A A phosphatase-resistant, active pppA2'p5'A2'p5'A analog.

1 reference

12 December 2020

Evolution of the genetic apparatus

1 reference

12 December 2020

Synthesis, properties and use of beta-alanyltyrosine derivatives of 2',5'-oligoadenylate 5'-triphosphate

1 reference

12 December 2020

Increased stability and antiviral activity of 2'-O-phosphoglyceryl derivatives of (2'-5')oligo(adenylate).

1 reference

12 December 2020

Raman spectroscopic measurement of base stacking in solutions of adenosine, AMP, ATP, and oligoadenylates

1 reference

12 December 2020

Interferon action: Two (2′-5′) (A)n synthetases specified by distinct mRNAs in Ehrlich ascites tumor cells treated with interferon

1 reference

12 December 2020

Interferon-independent activation of (2'-5') oligoadenylate synthetase in Friend erythroleukemia cell variants exposed to HMBA.

1 reference

12 December 2020

Staurosporine inhibits interferon alpha-induced gene expression in Friend erythroleukemia cells through a PKC independent pathway

1 reference

12 December 2020

Immune and virus-induced interferons may activate cells by different derepressional mechanisms

1 reference

12 December 2020

Interferon, double-stranded RNA and mRNA degradation

1 reference

12 December 2020

Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells

1 reference

12 December 2020

Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product

1 reference

12 December 2020

Novel 2',5'-oligoadenylates synthesized in interferon-treated, vaccinia virus-infected cells

1 reference

12 December 2020

24 Enzymic synthesis, purification, and fractionation of (2′-5′)-oligoadenylic acid

1 reference

12 December 2020

Extensive diversity of branched-RNA-linked multicopy single-stranded DNAs in clinical strains of Escherichia coli

1 reference

12 December 2020

Interferon-mediated Antiviral State in Human MRC5 Cells in the Absence of Detectable Levels of 2-5A Synthetase and Protein Kinase

1 reference

12 December 2020

Catalytic cleavage of an RNA target by 2-5A antisense and RNase L.

1 reference

12 December 2020

Association of IDDM and attenuated response of 2',5'-oligoadenylate synthetase to yellow fever vaccine

1 reference

12 December 2020

2′5′ Obgoadenylate synthetase, an interferon induced enzyme: direct assay methods for the products, 2′5′ ohgoadenylates and 2′5′ co-oligonucleotides

1 reference

12 December 2020

Production of two human 2',5'-oligoadenylate synthetase enzymes in Escherichia coli

1 reference

12 December 2020

Binding of Tat Protein to TAR Region of Human Immunodeficiency Virus Type 1 Blocks TAR-Mediated Activation of (2′-5′)Oligoadenylate Synthetase

1 reference

12 December 2020

Photochemical crosslinking in oligonucleotide-protein complexes between a bromine-substituted 2-5A analog and 2-5A-dependent RNase by ultraviolet lamp or laser

1 reference

12 December 2020

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA

1 reference

12 December 2020

Synthesis and biological activity of uronic acid analogues of 2-5A[5'-O-triphosphoryladenylyl(2----5')adenylyl-(2'----5')adenosine]

1 reference

12 December 2020

Cleavage of oligoribonucleotides by the 2',5'-oligoadenylate- dependent ribonuclease L

1 reference

12 December 2020

Inhibition of CFU-E in rat bone marrow perfused with 2'-5'-oligoadenylate core

1 reference

12 December 2020

34 Assay of double-stranded RNA-dependent endonuclease activity

1 reference

12 December 2020

HIV-1 reverse transcriptase: inhibition by 2',5'-oligoadenylates.

1 reference

12 December 2020

Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase

1 reference

12 December 2020

Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix

1 reference

12 December 2020

Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA

1 reference

12 December 2020

Two molecular weight forms of human 2',5'-oligoadenylate synthetase have different activation requirements.

1 reference

12 December 2020

Respective role of each of the purine N7 nitrogens of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine in binding to and activation of the RNase L of mouse cells

1 reference

12 December 2020

Serum 2′-5′-Oligoadenylate Synthetase Levels and Clinical Response to Interferon-β Therapy in Women with Genital Human Papillomavirus Infection

1 reference

12 December 2020

[Induction of atypical interferon after heat shock].

1 reference

12 December 2020

Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras

1 reference

12 December 2020

The cordycepin analogue of 2,5A and its threo isomer. Chemical synthesis, conformation and biological activity

1 reference

12 December 2020

Induction of 2',5'-oligoadenylate synthetase by retinoic acid in two transformed human cell lines

1 reference

12 December 2020

An interferon-induced cellular enzyme is incorporated into virions

1 reference

12 December 2020

2′5′oligo(A) polymerase activity in serum of mice infected with EMC virus or treated with interferon

1 reference

12 December 2020

Elevated Levels of (2′-5′)Oligoadenylic Acid Polymerase Activity in Growth-Arrested Human Lymphoblastoid Namalva Cells

1 reference

12 December 2020

The catalysis of nucleotide polymerization by compounds of divalent lead

1 reference

12 December 2020

The recognition of viral RNA by mammalian ribosomes. An effect of interferon

1 reference

12 December 2020

Loss of heterozygosity on chromosome 1q in human breast cancer

1 reference

12 December 2020

Biological and clinical effects of the oral immunomodulator 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride in patients with malignancy

1 reference

12 December 2020

Formation of tubuloreticular inclusions in human lymphoma cells compared to the induction of 2'-5'-oligoadenylate synthetase by leucocyte interferon in dose-effect and kinetic studies

1 reference

12 December 2020

Inhibition of HIV-1 replication and activation of RNase L by phosphorothioate/phosphodiester 2',5'-oligoadenylate derivatives

1 reference

12 December 2020

Heterogeneous Nuclear RNA Promotes Synthesis of (2′,5′)Oligoadenylate and Is Cleaved by the (2′,5′)Oligoadenylate-Activated Endoribonuclease

1 reference

12 December 2020

Regulation of interferon-alpha-inducible cellular genes in human immunodeficiency virus-infected monocytes

1 reference

12 December 2020

Stimulation of 2',5'-oligoadenylate synthetase activity in sheep endometrium during pregnancy, by intrauterine infusion of ovine trophoblast protein-1, and by intramuscular administration of recombinant bovine interferon-alpha I1

1 reference

12 December 2020

Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes

1 reference

12 December 2020

Mechanism of pppA(2'p5‘A)n2'p5‘AOH synthesis in extracts of interferon-treated HeLa cells

1 reference

12 December 2020

Oligoadenylate and cyclic AMP: interrelation and mutual regulation.

1 reference

12 December 2020

Hormonal Regulation of Ovalbumin Synthesis in the Chick Oviduct

1 reference

12 December 2020

Purification of 2',5'-oligoadenylate synthetase from rabbit reticulocytes

1 reference

12 December 2020

Modulation of antiviral activity of interferon and 2',5'-oligoadenylate synthetase gene expression by mild hyperthermia (39.5 degrees C) in cultured human cells

1 reference

12 December 2020

Synthesis and characterization of composite nucleic acids containing 2', 5'-oligoriboadenylate linked to antisense DNA

1 reference

12 December 2020

Anti-mitogenic Function of Interferon-Induced (2′-5′)Oligo(adenylate) and Growth-Related Variations in Enzymes that Synthesize and Degrade This Oligonucleotide

1 reference

12 December 2020

Immune interferon inhibits proliferation and induces 2'-5'-oligoadenylate synthetase gene expression in human vascular smooth muscle cells

1 reference

12 December 2020

2',5'-Oligoadenylate synthetase levels in patients with multiple myeloma receiving maintenance therapy with interferon alpha 2b do not correlate with clinical response

1 reference

12 December 2020

Transcriptional activation of human (2'-5')oligoadenylate synthetase gene expression by the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate in type-I-interferon-treated HL-60 and HeLa cells

1 reference

12 December 2020

Alteration of nuclear (2'-5')oligoriboadenylate synthetase and nuclease activities preceding replication of human immunodeficiency virus in H9 cells.

1 reference

12 December 2020

2',5'-oligoadenylate synthetase in interferon-alpha- and acyclovir-treated herpes simplex virus-infected cells

1 reference

12 December 2020

Resistance of melanoma cell lines to interferons correlates with reduction of IFN-induced tyrosine phosphorylation. Induction of the anti-viral state by IFN is prevented by tyrosine kinase inhibitors.

1 reference

12 December 2020

Adenovirus virus-associated RNA and translation control

1 reference

12 December 2020

Increased sensitivity of cell-free protein synthesis to double-stranded RNA after interferon treatment

1 reference

12 December 2020

Lymphocytic 2',5'-oligoadenylate synthetase is insensitive to dsRNA and interferon stimulation in autoimmune BB rats

1 reference

12 December 2020

A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon

1 reference

12 December 2020

The origin and early evolution of life: prebiotic chemistry, the pre-RNA world, and time.

1 reference

12 December 2020

Activation of 2-5A-dependent RNase by analogs of 2-5A (5'-O-triphosphoryladenylyl(2'----5')adenylyl(2'----5')adenosine ) using 2',5'-tetraadenylate (core)-cellulose

1 reference

12 December 2020

Stringent control in E. coli

1 reference

12 December 2020

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1 reference

12 December 2020

Different mechanisms regulate the IFN-inducible expression of 40 kDa human 2'-5' oligo (A) synthetase in HeLa and Molt 4 cells

1 reference

12 December 2020

Mechanisms of action of human interferons. Induction of 2'5'-oligo(A) polymerase.

1 reference

12 December 2020

Molecular characterization of a patient with del(1)(q23-q25).

1 reference

12 December 2020

5'-O-Monophosphoryladenylyl(2' goes to 5')adenylyl(2' goes to 5')adenosine is an antagonist of the action of 5'-O-triphosphoryladenylyl-(2' goes to 5')adenylyl(2' goes to 5')adenosine and double-stranded RNA.

1 reference

12 December 2020

Configuration of the interferon-alpha/beta receptor complex determines the context of the biological response

1 reference

12 December 2020

Increased levels of (2'-5')oligo(A) polymerase activity in human lymphoblastoid cells treated with glucocorticoids

1 reference

12 December 2020

Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA

1 reference

12 December 2020

Nuclease activation by double-stranded RNA and by 2′,5′-oligoadenylate in extracts of interferon-treated chick cells

1 reference

12 December 2020

Interferon Stimulates the Expression of 2′,5′ -Oligoadenylate Synthetase and MHC Class I Antigens in Insulin-Producing Cells

1 reference

12 December 2020

Diabetes mellitus and autoimmunity in patients with the congenital rubella syndrome

1 reference

12 December 2020

Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships

1 reference

12 December 2020

2',5'-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits

1 reference

12 December 2020

The 2-5A system in control and interferon-treated K/BALB cells infected with encephalomyocarditis virus.

1 reference

12 December 2020

Interferons, double-stranded RNA, and RNA degradation. Isolation and characterization of homogeneous human (2'-5')(a)n synthetase

1 reference

12 December 2020

Activation of interferon-inducible 2'-5' oligoadenylate synthetase by adenoviral VAI RNA.

1 reference

12 December 2020

A new and potent 2-5A analogue which does not require a 5'-polyphosphate to activate mouse L-cell RNase L

1 reference

12 December 2020

Mechanism of interferon action. Effect of double-stranded RNA and the 5'-O-monophosphate form of 2',5'-oligoadenylate on the inhibition of reovirus mRNA translation in vitro

1 reference

12 December 2020

Evidence that types I and II interferons have different receptors

1 reference

12 December 2020

The crystal and molecular structure of a dinucleoside phosphate: β-adenosine-2'-β-uridine-5'-phosphoric acid

1 reference

12 December 2020

Accumulation of 2',5'-oligoadenylates in encephalomyocarditis virus-infected mice

1 reference

12 December 2020

(2'-5') Oligoadenylate synthetase in the maturation of rabbit reticulocytes

1 reference

12 December 2020

Effect of glucose on antiviral activity of interferon

1 reference

12 December 2020

Recombinant interferon-beta 2 (interleukin-6) induces myeloid differentiation.

1 reference

12 December 2020

The human (2'-5') oligo A synthetase gene, structure of its two enzyme products and quick cell blot for clinical monitoring of its activation by interferons

1 reference

12 December 2020

Serum interferon level and (2'-5')oligoadenylate synthetase activity in lymphocytes during clinical interferon application

1 reference

12 December 2020

Concerning the mechanism of action of interferon

1 reference

12 December 2020

Synthesis and biological activity of 5'-capped derivatives of 5'-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine

1 reference

12 December 2020

1 reference

12 December 2020

Investigations on the interferon-induced 2'-5' oligoadenylate system using analytical capillary isotachophoresis

1 reference

12 December 2020

A sensitive assay for the IFN-regulated 2-5A synthetase enzyme

1 reference

12 December 2020

Phosphorothioate analogues of 2',5'-oligoadenylate. Activation of 2',5'-oligoadenylate-dependent endoribonuclease by 2',5'-phosphorothioate cores and 5'-monophosphates

1 reference

12 December 2020

Interferon-induced synthesis of 2-5A-dependent RNase in mouse JLS-V9R cells

1 reference

12 December 2020

Transcriptional regulation of interferon-responsive genes is closely linked to interferon receptor occupancy.

1 reference

12 December 2020

The binding of the 69- and 100-kD forms of 2',5'-oligoadenylate synthetase to different polynucleotides

1 reference

12 December 2020

(2'-5')-Oligo-3'-deoxynucleotides: selective binding to single-stranded RNA but not DNA.

1 reference

12 December 2020

A hybrid protein kinase-RNase in an interferon-induced pathway?

1 reference

12 December 2020

2',5'-Oligoadenylate:antisense chimeras--synthesis and properties

1 reference

12 December 2020

Interferon, double-stranded RNA, and RNA degradation: activation of an endonuclease by (2'-5')An

1 reference

12 December 2020

Preparation of the individual diastereomers of adenylyl-(2'-5')-P-thioadenylyl-(2'-5')-adenosine and their 5'-phosphorylated derivatives

1 reference

12 December 2020

Cordycepin analogs of ppp5'A2'p5'A2'p5'A (2-5A) inhibit protein synthesis through activation of the 2-5A-dependent endonuclease

1 reference

12 December 2020

Induction of an antiviral state by interferon in the absence of elevated levels of 2,5-oligo(A) synthetase and eIF-2 kinase

1 reference

12 December 2020

Role of 2',5'-oligo(adenylic acid) polymerase in the degradation of ribonucleic acid linked to double-stranded ribonucleic acid by extracts of interferon-treated cells

1 reference

12 December 2020

Rapid chemical synthesis and circular dichroism properties of some 2′-5′-linked oligoriboadenylates

1 reference

12 December 2020

Activation of human and mouse 2-5A synthetases and mouse protein P1 kinase by nucleic acids. Structure-activity relationships and correlations with inhibition of protein synthesis and interferon induction

1 reference

12 December 2020

Interferon action: binding of viral RNA to the 40-kilodalton 2'-5'-oligoadenylate synthetase in interferon-treated HeLa cells infected with encephalomyocarditis virus

1 reference

12 December 2020

Oligonucleotide structural parameters that influence binding of 5'-O-triphosphoadenylyl-(2'----5')-adenylyl-(2'----5')-adenosine to the 5'-O-triphosphoadenylyl-(2'----5')-adenylyl-(2'----5')-adenosine dependent endoribonuclease: chain length, phosph

1 reference

12 December 2020

Human trophoblast interferons

1 reference

12 December 2020

A simple and convenient synthesis of 3′-5′- or 2′-5′-linked oligoribonucleotide by polymerization of unprotected ribonucleoside using phosphorus tris-azole

1 reference

12 December 2020

5'-modified agonist and antagonist (2'-5')(A)n analogues: synthesis and biological activity

1 reference

12 December 2020

Synthesis of (2'-5')(A)n from ATP. Characteristics of the reaction catalyzed by (2'-5')(A)n synthetase purified from mouse Ehrlich ascites tumor cells treated with interferon

1 reference

12 December 2020

Phosphorothioate analogues of (2'-5')(A)4: agonist and antagonist activities in intact cells.

1 reference

12 December 2020

Protein synthesis in cell-free systems: an effect of interferon

1 reference

12 December 2020

Type I Conceptus Interferons: Maternal Recognition of Pregnancy Signals and Potential Therapeutic Agents

1 reference

12 December 2020

Oligonucleotide structural features involved in binding to and activation of the 2-5A-dependent endoribonuclease of L cells.

1 reference

12 December 2020

Virus interference. I. The interferon

1 reference

12 December 2020

Protection of HeLa‐T4 + cells against human immunodeficiency virus (HIV) infection after stable transfection with HIV LTR‐2‘,5‘‐oligoadenylate synthetase hybrid gene 1

1 reference

12 December 2020

Control of the ppp(a2'p)nA system in HeLa cells. Effects of interferon and virus infection

1 reference

12 December 2020

Differential gene expression of IFN-alpha and tumor necrosis factor-alpha in peripheral blood mononuclear cells from patients with AIDS related complex and AIDS

1 reference

12 December 2020

Modulation of nuclear matrix-associated 2',5'-oligoadenylate metabolism and ribonuclease L activity in H9 cells by human immunodeficiency virus

1 reference

12 December 2020

Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts

1 reference

12 December 2020

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA.

1 reference

12 December 2020

Lectins modulate the internalization of recombinant interferon-alpha A and the induction of 2',5'-oligo(A) synthetase.

1 reference

12 December 2020

Regulation of Bovine Endometrial Secretion of Prostaglandins and Synthesis of 2′,5′-Oligoadenylate Synthetase by Interferon-α Molecules

1 reference

12 December 2020

Synthesis and Breakdown of pppA2'p5'A2'p5'A and Transient Inhibition of Protein Synthesis in Extracts from Interferon-Treated and Control Cells

1 reference

12 December 2020

Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences

1 reference

12 December 2020

Inhibition of mouse fibroblast interferon by gangliosides. Differential effects on biological activity and on induction of (2'--5')oligoadenylate synthetase

1 reference

12 December 2020

Induction of intracellular and plasma 2',5'-oligoadenylate synthetase by pentostatin

1 reference

12 December 2020

Infection with Moloney murine sarcoma virus inhibits myogenesis and alters the myogenic-associated (2'-5')oligoadenylate synthetase expression and activity

1 reference

12 December 2020

Why do nucleic acids have 3′5′ phosphodiester bonds?

1 reference

12 December 2020

Suppression of Interferon-induced Oligo-2',5'-adenylate Synthetase Induction in Persistent Infection

1 reference

12 December 2020

Arachidonic acid regulates the binding of human interferon in human skin fibroblasts

1 reference

12 December 2020

RNA Double Helix and the Evolution of the 3′,5′ Linkage

1 reference

12 December 2020

2',5'-Oligoadenylate (2-5A) binding protein (RNase L) changes in AIDS and mammalian cells/tissues

1 reference

12 December 2020

Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro.

1 reference

12 December 2020

Porcine Conceptus Proteins: Antiviral Activity and Effect on 2′,5′-Oligoadenylate Synthetase1

1 reference

12 December 2020

Respective role of each of the purine N-6 amino groups of 5'-O-triphosphoryladenylyl(2'----5')adenylyl(2----5')adenosine in binding to and activation of RNase L.

1 reference

12 December 2020

Synthesis and biological activities of a phosphorodithioate analog of 2',5'-oligoadenylate

1 reference

12 December 2020

Interferon-gamma is not an antiviral, but a growth-promoting factor for T lymphocytes.

1 reference

12 December 2020

Expression of the 2-5A system during the cell cycle.

1 reference

12 December 2020

The nuclear matrix: structure and composition

1 reference

12 December 2020

Influence of the phosphodiester linkage (3'-5', 2'-5', and 5'-5') on the conformation of dinucleoside monophosphate.

1 reference

12 December 2020

Regulation of ppp(A2'p)nA-dependent RNase levels during interferon treatment and cell differentiation

1 reference

12 December 2020

Activation of 2',5'-oligoadenylate synthetase activity on induction of HL-60 leukemia cell differentiation

1 reference

12 December 2020

Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action

1 reference

12 December 2020

Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway

1 reference

12 December 2020

Involvement of interferon-system in the regulation of cell growth and differentiation

1 reference

12 December 2020

Determination of 2'-5'-oligoadenylate synthetase in serum and peripheral blood mononuclear cells before and after subcutaneous application of recombinant interferon beta and gamma

1 reference

12 December 2020

Degradation of rRNA in interferon-treated vaccinia virus-infected cells

1 reference

12 December 2020

Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus

1 reference

12 December 2020

Nonenzymatic template-directed synthesis of informational macromolecules.

1 reference

12 December 2020

Cell cycle regulation (G1) by autocrine interferon and dissociation between autocrine interferon and 2',5'-oligoadenylate synthetase expression

1 reference

12 December 2020

Interferon action: isolation of nuclease F, a translation inhibitor activated by interferon-induced (2'-5') oligo-isoadenylate

1 reference

12 December 2020

Inhibition of protein synthesis directed by added viral and cellular messenger RNAs in extracts of interferon-treated Ehrlich ascites tumor cells. Location and dominance of the inhibitor(s)

1 reference

12 December 2020

Efficient oligoadenylate synthesis catalyzed by uranyl ion complex in aqueous solution

1 reference

12 December 2020

An efficient and stereoselective synthesis of 2',5'-oligo-(SP)-thioadenylates

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

A heterodimeric nuclear protein complex binds two palindromic sequences in the proximal enhancer of the human erbB-2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Synthesis of adenylyl-(2′→5′)-adenylyl-(2′→5′)-adenosine (2-5A core)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Origin of life: The RNA world

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

The tetraisopropyldisiloxane-1,3-diyl: a versatile protecting group for the synthesis of adenylyl-(2′→5′)-adenylyl-(2′→5′)-adenosine (2-5a core)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Synthesis and Activity of Oligonucleotides Containing a Biologically Active Nucleoside at the 2′End

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Synthesis and Biological Activity of 3′-Modified 2′-5′ Adenylate Trimers

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Nucleotides. Part. XXXII. Synthesis of 2?-5? Connected oligonucleotides. Prodrugs for antiviral and antitumoral nucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Nucleotides. Part XXXI. Modified Oligomeric 2?-5? A Analogues: Synthesis of 2?-5? oligonucleotides with 9-(3?-azido-3?-deoxy-?-D-xylofuranosyl)adenine and 9-(3?-amino-3?-deoxy-?-D-xylofuranosyl)adenine as modified nucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Nucleotides. Part XXXIVSynthesis of Modified Oligomeric 2?-5?A Analogues: Potential Antiviral Agents

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Solid Phase Synthesis of 2′, 5′-Oligoadenylates Containing 3′-Fluorinated Ribose

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Selective Binding of RNA, but Not DNA, by Complementary 2‘,5‘-Linked DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Assessment of competing 2′«5′ versus 3′«5′ stackings in solution structure of branched-RNA by 1H- & 31 P-NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

Pseudo-rotation in the hydrolysis of phosphate esters

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900167-8

7 January 2021

10.1016/S0163-7258(97)00167-8

Identifiers

DOI

1 reference

2 September 2017

1 reference

PubMed ID

9623881