(Q38347059)

English

Lectin-based drug design: combined strategy to identify lead compounds using STD NMR spectroscopy, solid-phase assays and cell binding for a plant toxin model.

scientific article published on March 2010

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scholarly article

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17 January 2020

Lectin-based drug design: combined strategy to identify lead compounds using STD NMR spectroscopy, solid-phase assays and cell binding for a plant toxin model (English)

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17 January 2020

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ChEBI release 2020-05-28

Hans-Joachim Gabius

4

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17 January 2020

João P Ribeiro

1

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17 January 2020

2

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17 January 2020

Francisco Javier Cañada

3

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17 January 2020

Jesús Jiménez-Barbero

7

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17 January 2020

author name string

Anna Paola Butera

5

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17 January 2020

Ricardo José Alves

6

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17 January 2020

publication date

1 March 2010

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17 January 2020

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17 January 2020

5

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17 January 2020

3

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17 January 2020

415-9, 314

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17 January 2020

Medicinal Chemistry Based on the Sugar Code: Fundamentals of Lectinology and Experimental Strategies with Lectins as Targets

1 reference

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NMR investigations of protein-carbohydrate interactions: insights into the topology of the bound conformation of a lactose isomer and beta-galactosyl xyloses to mistletoe lectin and galectin-1.

1 reference

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21 January 2018

Branching mode in complex-type triantennary N-glycans as regulatory element of their ligand properties

1 reference

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21 January 2018

Towards defining the role of glycans as hardware in information storage and transfer: basic principles, experimental approaches and recent progress.

1 reference

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Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

1 reference

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7 January 2021

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NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors

1 reference

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7 January 2021

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Probing the cons and pros of lectin-induced immunomodulation: case studies for the mistletoe lectin and galectin-1.

1 reference

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7 January 2021

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Evidence for stimulation of tumor proliferation in cell lines and histotypic cultures by clinically relevant low doses of the galactoside-binding mistletoe lectin, a component of proprietary extracts

1 reference

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7 January 2021

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Ribosome-inactivating proteins

1 reference

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7 January 2021

based on heuristic

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Further refinement of the description of the ligand-binding characteristics for the galactoside-binding mistletoe lectin, a plant agglutinin with immunomodulatory potency

1 reference

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7 January 2021

based on heuristic

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Microcalorimetric indications for ligand binding as a function of the protein for galactoside-specific plant and avian lectins

1 reference

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7 January 2021

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Computational and Experimental NMR Definition of Differences in the Conformational Behavior of Free and Lectin-Bound Glycomimetic Aza/Carba-Lactosides

1 reference

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7 January 2021

based on heuristic

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Synthesis and conformational analysis of (alpha-D-galactosyl)phenylmethane and alpha-,beta-difluoromethane analogues: interactions with the plant lectin viscumin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Glycan tagging to produce bioactive ligands for a surface plasmon resonance study via immobilization on different surfaces.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Monomer/dimer equilibrium of the AB-type lectin from mistletoe enables combination of toxin/agglutinin activities in one protein: analysis of native and citraconylated proteins by ultracentrifugation/gel filtration and cell biological consequences o

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

inferred from DOI database lookup

AB-type lectin (toxin/agglutinin) from mistletoe: differences in affinity of the two galactoside-binding Trp/Tyr-sites and regulation of their functionality by monomer/dimer equilibrium.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Glycosyldisulfides from dynamic combinatorial libraries as O-glycoside mimetics for plant and endogenous lectins: their reactivities in solid-phase and cell assays and conformational analysis by molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

inferred from DOI database lookup

Domain versatility in plant AB-toxins: evidence for a local, pH-dependent rearrangement in the 2gamma lectin site of the mistletoe lectin by applying ligand derivatives and modelling

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

inferred from DOI database lookup

Small angle neutron scattering as sensitive tool to detect ligand-dependent shape changes in a plant lectin with beta-trefoil folding and their dependence on the nature of the solvent

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

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Determination of the binding specificity of an integral membrane protein by saturation transfer difference NMR: RGD peptide ligands binding to integrin alphaIIbbeta3.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

inferred from DOI database lookup

Mistletoe lectin I in complex with galactose and lactose reveals distinct sugar-binding properties

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Lactose-containing starburst dendrimers: influence of dendrimer generation and binding-site orientation of receptors (plant/animal lectins and immunoglobulins) on binding properties

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein-carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targets

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Calix[n]arene-based glycoclusters: bioactivity of thiourea-linked galactose/lactose moieties as inhibitors of binding of medically relevant lectins to a glycoprotein and cell-surface glycoconjugates and selectivity among human adhesion/growth-regula

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Carbamate-linked lactose: design of clusters and evidence for selectivity to block binding of human lectins to (neo)glycoproteins with increasing degree of branching and to tumor cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Synthesis of bivalent lactosides based on terephthalamide, N,N'-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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α-O-Linked Glycopeptide Mimetics: Synthesis, Conformation Analysis, and Interactions with Viscumin, a Galactoside-Binding Model Lectin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

inferred from DOI database lookup

Substitutions in theN-Glycan Core as Regulators of Biorecognition: The Case of Core-Fucose and Bisecting GlcNAc Moieties†

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Human galectins as sensors for apoptosis/necrosis-associated surface changes of granulocytes and lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

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Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900476

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.200900476

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20094999%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20094999%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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