(Q38355676)

2 September 2017

title

Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity (English)

1 reference

2 September 2017

Poor Cell Surface Expression of Human Melanocortin-4 Receptor Mutations Associated with Obesity (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

regulation of gene expression

23 December 2023

main subject

obesity

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12690102

23 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

23 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

23 December 2023

author name string

Wouter A. J. Nijenhuis

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12690102

23 December 2023

Keith M. Garner

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12690102

23 December 2023

Rea J. van Rozen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12690102

23 December 2023

Roger A. H. Adan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12690102

23 December 2023

language of work or name

English

0 references

publication date

9 April 2003

1 reference

full work available at URL

2 September 2017

http://www.jbc.org/article/S0021925820863479/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12690102

https://api.elsevier.com/content/article/PII:S0021925820863479?httpAccept=text/xml

23 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

https://api.elsevier.com/content/article/PII:S0021925820863479?httpAccept=text/plain

23 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

https://syndication.highwire.org/content/doi/10.1074/jbc.M211326200

23 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Journal of Biological Chemistry

23 December 2023

published in

1 reference

2 September 2017

volume

278

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2 September 2017

issue

25

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2 September 2017

page(s)

22939-22945

1 reference

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation

2 September 2017

cites work

2

1 reference

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Molecular characterization of the mouse agouti locus.

23 December 2023

3

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

23 December 2023

4

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Overexpression of Agrt leads to obesity in transgenic mice.

23 December 2023

5

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

23 December 2023

6

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

23 December 2023

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1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats

23 December 2023

8

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

23 December 2023

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1 reference

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

23 December 2023

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1 reference

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A frameshift mutation in MC4R associated with dominantly inherited human obesity

23 December 2023

11

1 reference

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A frameshift mutation in human MC4R is associated with a dominant form of obesity

23 December 2023

12

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans

23 December 2023

13

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Identification and functional analysis of novel human melanocortin-4 receptor variants

23 December 2023

14

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

23 December 2023

15

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

23 December 2023

16

1 reference

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Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children

23 December 2023

17

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity

23 December 2023

18

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

A Novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity

23 December 2023

19

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol

23 December 2023

20

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene

23 December 2023

21

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Functional characterization of mutations in melanocortin-4 receptor associated with human obesity

23 December 2023

23

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

A colorimetric assay for measuring activation of Gs- and Gq-coupled signaling pathways

23 December 2023

24

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptors

23 December 2023

25

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Deletions of the N-terminal regions of the human melanocortin receptors

23 December 2023

27

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Biochemical, biophysical, and pharmacological characterization of bacterially expressed human agouti-related protein

23 December 2023

28

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo

23 December 2023

29

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Characterization of Agouti-related protein binding to melanocortin receptors

23 December 2023

30

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Functional characterization of five V2 vasopressin receptor gene mutations

23 December 2023

32

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein

23 December 2023

34

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Ligand rescue of constitutively active mutant receptors

23 December 2023

36

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

23 December 2023

37

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

23 December 2023

38

1 reference

https://api.crossref.org/works/10.1074/JBC.M211326200

23 December 2023

Identifiers

1 reference

2 September 2017

1 reference