(Q38360180)

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Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate-1 (IRS-1) but fail to mediate the biological effects of insulin. Evidence that IRS-1 phosphorylation is not sufficient for normal insulin action

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Europe PubMed Central

PubMed publication ID

2 September 2017

Two naturally occurring mutant insulin receptors phosphorylate insulin receptor substrate-1 (IRS-1) but fail to mediate the biological effects of insulin. Evidence that IRS-1 phosphorylation is not sufficient for normal insulin action (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

phosphorylation

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Krook A

1

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Europe PubMed Central

PubMed publication ID

2 September 2017

Moller DE

2

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Europe PubMed Central

PubMed publication ID

2 September 2017

Dib K

3

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

O'Rahilly S

4

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Europe PubMed Central

PubMed publication ID

2 September 2017

language of work or name

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publication date

1 March 1996

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Europe PubMed Central

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2 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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2 September 2017

271

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Europe PubMed Central

PubMed publication ID

2 September 2017

12

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Europe PubMed Central

PubMed publication ID

2 September 2017

7134-7140

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Europe PubMed Central

PubMed publication ID

2 September 2017

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Induction of insulitis in athymic (nude) mice. The effect of NOD thymus and pancreas transplantation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Gender and insulin sensitivity in the heart and in skeletal muscles. Studies using positron emission tomography.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Activation of phosphatidylinositol 3-kinase by insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Signal transduction by receptors with tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.12.7134

21 January 2018

Identifiers

10.1074/JBC.271.12.7134

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

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