(Q38423724)

3 September 2017

1 reference

title

Next generation vaccines and vectors: Designing downstream processes for recombinant protein-based virus-like particles (English)

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3 September 2017

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Christopher Ladd Effio

series ordinal

1

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PubMed ID

25880158

3 September 2017

Jürgen Hubbuch

series ordinal

2

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3 September 2017

16 April 2015

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3 September 2017

Biotechnology Journal

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3 September 2017

10

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3 September 2017

5

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3 September 2017

715-727

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Virus-like particles-universal molecular toolboxes

3 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Development of the RTS,S/AS malaria candidate vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Vaccine efficacy against malaria by the combination of porcine parvovirus-like particles and vaccinia virus vectors expressing CS of Plasmodium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Aβ-HBc virus-like particles immunization without additional adjuvant ameliorates the learning and memory and reduces Aβ deposit in PDAPP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Preclinical efficacy and safety of an anti-IL-1β vaccine for the treatment of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Highly specific auto-antibodies against claudin-18 isoform 2 induced by a chimeric HBcAg virus-like particle vaccine kill tumor cells and inhibit the growth of lung metastases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Stimulating antitumor immunity with nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Active immunotherapy for chronic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Large-scale production and purification of VLP-based vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Development of virus-like particle technology from small highly symmetric to large complex virus-like particle structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Construction and characterization of virus-like particles: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Bioengineering virus-like particles as vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Inequalities in Human Papillomavirus (HPV)-associated cancers: implications for the success of HPV vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Decreased management of genital warts in young women in Australian general practice post introduction of national HPV vaccination program: results from a nationally representative cross-sectional general practice study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Effects in humans of intravenously administered endotoxin on soluble cell-adhesion molecule and inflammatory markers: a model of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Safety and immunogenicity of a candidate parvovirus B19 vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Acceptable levels of endotoxin in vaccine formulations during preclinical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Purification of virus-like particles of recombinant human papillomavirus type 11 major capsid protein L1 from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Disassembly and reassembly of yeast-derived recombinant human papillomavirus virus-like particles (HPV VLPs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

In vitro-reassembled plant virus-like particles for loading of polyacids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Structure of hepatitis E virion-sized particle reveals an RNA-dependent viral assembly pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

On the effect of thermodynamic equilibrium on the assembly efficiency of complex multi-layered virus-like particles (VLP): the case of rotavirus VLP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Disassembly and reassembly improves morphology and thermal stability of human papillomavirus type 16 virus-like particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Molecular energetics in the capsomere of virus-like particle revealed by molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Stabilization of human papillomavirus virus-like particles by non-ionic surfactants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Modeling the competition between aggregation and self-assembly during virus-like particle processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Human parvovirus B19 virus-like particles: In vitro assembly and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Selective flocculation and precipitation for the improvement of virus-like particle recovery from yeast homogenate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Purification and immunogenicity study of human papillomavirus 58 virus-like particles expressed in Pichia pastoris

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the hepatitis B surface antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Use of hollow fiber tangential flow filtration for the recovery and concentration of HIV virus-like particles produced in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Downstream processing of triple layered rotavirus like particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Exploitation of the adsorptive properties of depth filters for host cell protein removal during monoclonal antibody purification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Enterovirus 71 virus-like particle vaccine: improved production conditions for enhanced yield

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Evaluation of four virus recovery methods for detecting noroviruses on fresh lettuce, sliced ham, and frozen raspberries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Concentration and purification of enterovirus 71 using a weak anion-exchange monolithic column

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Inactivation and purification of cowpea mosaic virus-like particles displaying peptide antigens from Bacillus anthracis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Effective chikungunya virus-like particle vaccine produced in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

High-throughput screening techniques for rapid PEG-based precipitation of IgG4 mAb from clarified cell culture supernatant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

A single-use purification process for the production of a monoclonal antibody produced in a PER.C6 human cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Alternative separation steps for monoclonal antibody purification: combination of centrifugal partitioning chromatography and precipitation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Depletion theory and the precipitation of protein by polymer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Protein precipitation by polyethylene glycol: a generalized model based on hydrodynamic radius.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Size fractionation of double-stranded DNA by precipitation with polyethylene glycol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Polymethacrylate monoliths for preparative and industrial separation of biomolecular assemblies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

A novel stationary phase derivatized from hydrophilic gigaporous polystyrene-based microspheres for high-speed protein chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Recent advances in bioprocessing application of membrane chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Purification and analysis of polyhistidine-tagged human parvovirus B19 VP1 and VP2 expressed in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Affinity purification of viral protein having heterogeneous quaternary structure: modeling the impact of soluble aggregates on chromatographic performance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Purification and concentration of non-infectious West Nile virus-like particles and infectious virions using a pseudo-affinity Cellufine Sulfate column

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Chromatographically-purified capsid proteins of red-spotted grouper nervous necrosis virus expressed in Saccharomyces cerevisiae form virus-like particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Rapid and simplified purification of recombinant adeno-associated virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Ion-exchange chromatography of hepatitis B virus surface antigen from a recombinant Chinese hamster ovary cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Purification of recombinant adenovirus type 3 dodecahedric virus-like particles for biomedical applications using short monolithic columns

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Secreted production of assembled Norovirus virus-like particles from Pichia pastoris

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Generation of a parvovirus B19 vaccine candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

An automated microscale chromatographic purification of virus-like particles as a strategy for process development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Principles and applications of steric exclusion chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

A monolith purification process for virus-like particles from yeast homogenate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Aqueous two-phase systems: A viable platform in the manufacturing of biopharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

High-throughput screening-based selection and scale-up of aqueous two-phase systems for pDNA purification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Continuous aqueous two-phase extraction of human antibodies using a packed column.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

21 January 2018

Integrated bioprocesses

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Rotavirus-like particles primary recovery from insect cells in aqueous two-phase systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Effect of different operating modes and biomass concentrations on the recovery of recombinant hepatitis B core antigen from thermal-treated unclarified Escherichia coli feedstock

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Purification of His-tagged hepatitis B core antigen from unclarified bacterial homogenate using immobilized metal affinity-expanded bed adsorption chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Reduced surface area chromatography for flow-through purification of viruses and virus like particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

One-step chromatographic purification of human papillomavirus type 16 L1 protein from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Enhanced production of Chikungunya virus-like particles using a high-pH adapted spodoptera frugiperda insect cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Efficient disulfide bond formation in virus-like particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

A quantitative description of in vitro assembly of human papillomavirus 16 virus-like particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Influenza M1 VLPs containing neuraminidase induce heterosubtypic cross-protection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Quality by design for biopharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Utilizing dynamic light scattering as a process analytical technology for protein folding and aggregation monitoring in vaccine manufacturing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

High throughput screening based selection of phases for aqueous two-phase system-centrifugal partitioning chromatography of monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Virus-like particle formulation optimization by miniaturized high-throughput screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Norwalk virus assembly and stability monitored by mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Interrogating viral capsid assembly with ion mobility-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Quantitative real-time single particle analysis of virions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

A tool for selective inline quantification of co-eluting proteins in chromatography using spectral analysis and partial least squares regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Continuous purification of influenza virus using simulated moving bed chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Adenovirus purification by two-column, size-exclusion, simulated countercurrent chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Chikungunya virus-like particles are more immunogenic in a lethal AG129 mouse model compared to glycoprotein E1 or E2 subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Next generation dengue vaccines: a review of candidates in preclinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

HPV vaccines: preclinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Improved characteristics and protective efficacy in an animal model of E. coli-derived recombinant double-layered rotavirus virus-like particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

International community ramps up Ebola vaccine effort

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

A recombinant viruslike particle influenza A (H7N9) vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Safety and immunogenicity of a Sf9 insect cell-derived respiratory syncytial virus fusion protein nanoparticle vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Update on vaccination clinical trials for HPV-related disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Efficacy of the HPV-16/18 vaccine: final according to protocol results from the blinded phase of the randomized Costa Rica HPV-16/18 vaccine trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Immunogenicity and safety of the candidate RTS,S/AS01 vaccine in young Nigerian children: a randomized, double-blind, lot-to-lot consistency trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

HPV vaccines to prevent cervical cancer and genital warts: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Robust manufacturing and comprehensive characterization of recombinant hepatitis E virus-like particles in Hecolin(®).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Purification of recombinant nucleocapsid protein of Newcastle disease virus from unclarified feedstock using expanded bed adsorption chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Characterization and downstream processing of HIV-1 core and virus-like-particles produced in serum free medium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Anion-exchange membrane chromatography for purification of rotavirus-like particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

Purification of norovirus-like particles (VLPs) by ion exchange chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400392

21 January 2018

Identifiers

DOI

10.1002/BIOT.201400392

1 reference

3 September 2017

1 reference

PubMed ID

25880158