(Q38436671)

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Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2.

scientific article published on 03 August 2006

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28 December 2019

Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2 (English)

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28 December 2019

Rhett P. Ketterling

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28 December 2019

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Einerson RR

1

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28 December 2019

Law ME

2

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28 December 2019

Blair HE

3

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28 December 2019

Kurtin PJ

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28 December 2019

McClure RF

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28 December 2019

Flynn HC

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28 December 2019

Dogan A

8

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28 December 2019

Remstein ED

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28 December 2019

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3 August 2006

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28 December 2019

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28 December 2019

20

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28 December 2019

10

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28 December 2019

1790-1799

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28 December 2019

Adult B-cell lymphomas with burkitt-like morphology are phenotypically and genotypically heterogeneous with aggressive clinical behavior.

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Heterogeneous pattern of chromosomal breakpoints involving the MYC locus in multiple myeloma.

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Variable breakpoints in Burkitt lymphoma cells with chromosomal t(8;14) translocation separate c-myc and the IgH locus up to several hundred kb.

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Interphase fluorescence in situ hybridization for detection of 8q24/MYC breakpoints on routine histologic sections: validation in Burkitt lymphomas from three geographic regions

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Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc

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Homogeneous immunophenotype and paucity of secondary genomic aberrations are distinctive features of endemic but not of sporadic Burkitt's lymphoma and diffuse large B-cell lymphoma with MYC rearrangement

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Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3' side of MYC.

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21 January 2018

Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia

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21 January 2018

Sequence analysis of the MYC oncogene involved in the t(8;14)(q24;q11) chromosome translocation in a human leukemia T-cell line indicates that putative regulatory regions are not altered

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21 January 2018

A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia

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21 January 2018

Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC fusion transcript

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21 January 2018

Topological organization of the MYC/IGK locus in Burkitt's lymphoma cells assessed by nuclear halo preparations

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Characterization of chromosome 8 abnormalities by fluorescence in situ hybridization in childhood B-acute lymphoblastic leukemia/non-Hodgkin lymphoma

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Differential expression of the normal and of the translocated human c-myc oncogenes in B cells

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21 January 2018

Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription

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Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt

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A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma

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Gene regulation by proteins acting nearby and at a distance

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An enhancer stimulates transcription in trans when attached to the promoter via a protein bridge

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Interaction between transcription regulatory regions of prolactin chromatin

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Mechanisms of Igf2/H19 imprinting: DNA methylation, chromatin and long-distance gene regulation

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Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU.

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21 January 2018

Chromosomal loop anchorage sites appear to be evolutionarily conserved

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Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

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Nomenclature of the human immunoglobulin kappa (IGK) genes

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Nucleotide sequence of the intron of the germline human kappa immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer

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Human immunoglobulin kappa gene enhancer: chromatin structure analysis at high resolution

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The human CK gene segment and the kappa deleting element are closely linked

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Nomenclature of the human immunoglobulin lambda (IGL) genes

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One-megabase sequence analysis of the human immunoglobulin lambda gene locus

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Prognostic value of cytogenetics in multiple myeloma

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Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis

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Identifiers

10.1038/SJ.LEU.2404340

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16888615%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16888615%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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