(Q38455632)

3 September 2017

title

Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600. (English)

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3 September 2017

main subject

Streptomyces platensis

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(Z)-N-[2-hydroxy-3-(hydroxymethyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-7-[(2S)-2-hydroxy-3-methylidene-1-bicyclo[2.2.2]octanyl]-4,4-dimethyl-5-oxohept-6-enamide

1 reference

(6Z)-N-{2-hydroxy-3-[(methylsulfanyl)carbonyl]-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl}-7-{2-hydroxy-5-methylidenebicyclo[2.2.2]octan-1-yl}-4,4-dimethyl-5-oxohept-6-enimidic acid

1 reference

3-[[(Z)-7-[(1S,3S,5S,7R)-3,9-dimethyl-2-oxatricyclo[3.3.1.03,7]nonan-5-yl]-4,4-dimethyl-5-oxohept-6-enoyl]amino]-2-hydroxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybenzoic acid

1 reference

2,4-dihydroxy-3-[3-[(1S,5S)-5-methyl-9-methylidene-4-oxo-5-tricyclo[6.2.2.01,6]dodec-2-enyl]propanoylamino]benzoic acid

1 reference

(Z)-N-[2-hydroxy-3-(hydroxymethyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-7-[(2R)-2-hydroxy-5-methylidene-1-bicyclo[2.2.2]octanyl]-4,4-dimethyl-5-oxohept-6-enamide

1 reference

N-[2-hydroxy-3-(hydroxymethyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-4,4-dimethyl-7-(3-methylidene-1-bicyclo[2.2.2]octanyl)-5-oxoheptanamide

1 reference

(6Z)-N-[2-hydroxy-3-(methoxycarbonyl)-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl]-7-{2-hydroxy-5-methylidenebicyclo[2.2.2]octan-1-yl}-4,4-dimethyl-5-oxohept-6-enimidic acid

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Zhiguo Yu

1

1 reference

3 September 2017

Mostafa E Rateb

2

1 reference

3 September 2017

Michael J Smanski

3

1 reference

3 September 2017

Ryan M Peterson

4

1 reference

3 September 2017

Ben Shen

5

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3 September 2017

publication date

30 January 2013

1 reference

full work available at URL

3 September 2017

https://www.nature.com/articles/ja20131.pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1038/ja.2013.1?email=unpaywall_01@example.com

published in

The Journal of Antibiotics

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3 September 2017

volume

66

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3 September 2017

issue

5

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3 September 2017

page(s)

291-294

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https://api.unpaywall.org/v2/10.1038/ja.2013.1?email=unpaywall_01@example.com

3 September 2017

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19 March 2024

access restriction status

open access

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inferred from online access status

cites work

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

1 reference

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

21 January 2018

1 reference

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

21 January 2018

1 reference

Platensimycin: a promising antimicrobial targeting fatty acid synthesis.

21 January 2018

1 reference

Platensimycin and platencin: promising antibiotics for future application in human medicine

21 January 2018

1 reference

Platensimycin and its relatives: a recent story in the struggle to develop new naturally derived antibiotics

21 January 2018

1 reference

Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis

21 January 2018

1 reference

Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis

21 January 2018

1 reference

Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensis

21 January 2018

1 reference

Isolation, structure and biological activities of platencin A(2)-A(4) from Streptomyces platensis

21 January 2018

1 reference

Platensimycin and platencin congeners from Streptomyces platensis

21 January 2018

1 reference

Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin.

21 January 2018

1 reference

Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners.

21 January 2018

1 reference

Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis.

21 January 2018

1 reference

Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners.

21 January 2018

1 reference

Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation

21 January 2018

1 reference

Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy

21 January 2018

1 reference

Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity

21 January 2018

1 reference

Structure of homoplatensimide A: a potential key biosynthetic intermediate of platensimycin isolated from Streptomyces platensis

21 January 2018

1 reference

7 January 2021

inferred from DOI database lookup

Structure and Semisynthesis of Platensimide A, Produced byStreptomyces platensis

1 reference

7 January 2021

inferred from DOI database lookup

Isolation, enzyme-bound structure, and activity of platensimycin A1 from Streptomyces platensis

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/JA.2013.1

1 reference

Dimensions Publication ID

3 September 2017

1020514852

0 references

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