(Q38543755)

4 September 2017

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title

Continuous downstream processing for high value biological products: A Review (English)

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4 September 2017

Andrew L Zydney

1

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4 September 2017

publication date

7 July 2015

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Biotechnology and Bioengineering

4 September 2017

published in

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4 September 2017

volume

113

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4 September 2017

issue

3

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4 September 2017

page(s)

465-475

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Large-scale cell culture in biotechnology

4 September 2017

cites work

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A continuous multicolumn countercurrent solvent gradient purification (MCSGP) process

21 January 2018

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Quality by design: impact of formulation variables and their interactions on quality attributes of a lyophilized monoclonal antibody

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Evaluation of radial chromatography versus axial chromatography, practical approach.

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Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process.

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Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production

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Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography.

21 January 2018

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Viral clearance using monoliths

21 January 2018

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A membrane stirrer for product recovery and substrate feeding.

21 January 2018

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CFD simulation of an internal spin-filter: evidence of lateral migration and exchange flow through the mesh

21 January 2018

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Zonal rate model for axial and radial flow membrane chromatography. Part I: knowledge transfer across operating conditions and scales

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Cation exchange surface-mediated denaturation of an aglycosylated immunoglobulin (IgG1).

21 January 2018

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Periodic counter-current chromatography -- design and operational considerations for integrated and continuous purification of proteins.

21 January 2018

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Unfolding of a model protein on ion exchange and mixed mode chromatography surfaces

21 January 2018

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Unfolding and aggregation of a glycosylated monoclonal antibody on a cation exchange column. Part II. Protein structure effects by hydrogen deuterium exchange mass spectrometry.

21 January 2018

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Economics of recombinant antibody production processes at various scales: Industry-standard compared to continuous precipitation.

21 January 2018

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Internal virus polarization model for virus retention by the Ultipor(®) VF Grade DV20 membrane

21 January 2018

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Avoiding antibody aggregation during processing: establishing hold times.

21 January 2018

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Continuous downstream processing of biopharmaceuticals.

21 January 2018

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Industrialization of mAb production technology: the bioprocessing industry at a crossroads

21 January 2018

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Understanding and modeling alternating tangential flow filtration for perfusion cell culture

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Online control of the twin-column countercurrent solvent gradient process for biochromatography.

21 January 2018

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Application of high-performance tangential flow filtration (HPTFF) to the purification of a human pharmaceutical antibody fragment expressed in Escherichia coli

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Design of a UV-C irradiation process for the inactivation of viruses in protein solutions.

21 January 2018

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Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP).

21 January 2018

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Effects of cell culture conditions on antibody N-linked glycosylation--what affects high mannose 5 glycoform

21 January 2018

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Simulated moving bed chromatography for the separation of enantiomers

21 January 2018

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Continuous processing for production of biopharmaceuticals

21 January 2018

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Countercurrent tangential chromatography for large-scale protein purification

21 January 2018

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Acoustic cell filter: a proven cell retention technology for perfusion of animal cell cultures

21 January 2018

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Preparative continuous annular chromatography (P-CAC), a review.

21 January 2018

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A new large-scale manufacturing platform for complex biopharmaceuticals

21 January 2018

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Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells

21 January 2018

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Integrated continuous production of recombinant therapeutic proteins.

21 January 2018

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Bioreactor systems for the production of biopharmaceuticals from animal cells

21 January 2018

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Anion exchange membrane adsorbers for flow-through polishing steps: Part II. Virus, host cell protein, DNA clearance, and antibody recovery

21 January 2018

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A novel perfusion system for animal cell cultures by two step sequential sedimentation

21 January 2018

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Towards protein crystallization as a process step in downstream processing of therapeutic antibodies: screening and optimization at microbatch scale

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.25695

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4 September 2017

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