(Q38586903)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26370700%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26370700%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26370700%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

author name string

Paul Fernyhough

series ordinal

1

1 reference

4 September 2017

publication date

1 November 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26370700%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

published in

Current diabetes report

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26370700%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26370700%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26370700%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

page(s)

89

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26370700%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s11892-015-0671-9

24 February 2020

exact match

0 references

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PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

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The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

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Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats

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Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

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Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

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12 December 2020

Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities

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12 December 2020

Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment

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Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors

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12 December 2020

The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy

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Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

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12 December 2020

Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

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The Crabtree effect: a review

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Critical dependence of neurons on mitochondrial dynamics

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Insulin inhibits AMPK activity and phosphorylates AMPK Ser⁴⁸⁵/⁴⁹¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle

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12 December 2020

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

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12 December 2020

The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

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12 December 2020

Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease

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12 December 2020

Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia

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12 December 2020

Reactive, degenerative, and proliferative Schwann cell responses in experimental galactose and human diabetic neuropathy

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12 December 2020

Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

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12 December 2020

Fine structure of myelinated mechanical nociceptor endings in cat hairy skin

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12 December 2020

Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain.

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12 December 2020

Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes

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12 December 2020

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

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12 December 2020

PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond

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12 December 2020

Resveratrol stimulates AMP kinase activity in neurons

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12 December 2020

Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes

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12 December 2020

Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation

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12 December 2020

PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload

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12 December 2020

Sural nerve pathology in diabetic patients with minimal but progressive neuropathy

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12 December 2020

GDNF levels in the lower lip skin in a rat model of trigeminal neuropathic pain: implications for nonpeptidergic fiber reinnervation and parasympathetic sprouting

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Ischemic conduction failure and energy metabolism in experimental diabetic neuropathy.

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Diabetic neuropathy--a review

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C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons

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12 December 2020

AMPK: a key regulator of energy balance in the single cell and the whole organism.

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12 December 2020

Pathology and pathogenetic mechanisms of diabetic neuropathy.

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12 December 2020

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

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12 December 2020

Biochemistry and molecular cell biology of diabetic complications

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12 December 2020

Actin-ATP hydrolysis is a major energy drain for neurons.

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12 December 2020

Quantitation of epidermal nerves in diabetic neuropathy

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12 December 2020

Comparable myelinated nerve pathology in feline and human diabetes mellitus

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12 December 2020

ADP regulates movements of mitochondria in neurons

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12 December 2020

Aldose reductase drives hyperacetylation of Egr-1 in hyperglycemia and consequent upregulation of proinflammatory and prothrombotic signals.

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12 December 2020

A study of the peripheral nerves in diabetic subjects during ischaemia

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12 December 2020

Glucose neurotoxicity

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12 December 2020

Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models

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12 December 2020

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

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12 December 2020

Subcellular localization of Nox4 and regulation in diabetes

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12 December 2020

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

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12 December 2020

Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491.

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Deficient nonpeptidergic epidermis innervation and reduced inflammatory pain in glial cell line-derived neurotrophic factor family receptor alpha2 knock-out mice.

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12 December 2020

Restorative effects of neurotrophin treatment on diabetes-induced cutaneous axon loss in mice

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12 December 2020

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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12 December 2020

Dystrophic axonal swellings develop as a function of age and diabetes in human dorsal root ganglia.

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12 December 2020

Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy

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12 December 2020

Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture

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12 December 2020

Endogenous NGF and nerve impulses regulate the collateral sprouting of sensory axons in the skin of the adult rat

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12 December 2020

Impulse conduction increases mitochondrial transport in adult mammalian peripheral nerves in vivo

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12 December 2020

Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy.

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12 December 2020

The skin as a neurotrophic organ

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12 December 2020

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

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12 December 2020

Evidence that endogenous beta nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats

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12 December 2020

High glucose downregulates endothelial progenitor cell number via SIRT1.

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12 December 2020

Terminal arbor degeneration--a novel lesion produced by the antineoplastic agent paclitaxel

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12 December 2020

Mitochondria, oxidants, and aging

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12 December 2020

Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy

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12 December 2020

Microtubule deacetylases, SirT2 and HDAC6, in the nervous system

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12 December 2020

Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects

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12 December 2020

Hyperglycemia- and neuropathy-induced changes in mitochondria within sensory nerves.

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12 December 2020

Electron microscopy of cutaneous nerves and receptors

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12 December 2020

Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice

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12 December 2020

Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy

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12 December 2020

Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

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12 December 2020

Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system.

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12 December 2020

Vesicular glycolysis provides on-board energy for fast axonal transport

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12 December 2020

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

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12 December 2020

Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies.

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12 December 2020

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

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12 December 2020

Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex

1 reference

12 December 2020

Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium

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12 December 2020

Experimental diabetic autonomic neuropathy

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12 December 2020

New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

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12 December 2020

The facilitative glucose transporter GLUT3: 20 years of distinction

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12 December 2020

Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle

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12 December 2020

PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis

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12 December 2020

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

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12 December 2020

High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway

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12 December 2020

Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy

1 reference

12 December 2020

SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.

1 reference

12 December 2020

Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF

1 reference

12 December 2020

Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents.

1 reference

12 December 2020

Aldose reductase, still a compelling target for diabetic neuropathy

1 reference

12 December 2020

A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort.

1 reference

12 December 2020

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

1 reference

12 December 2020

Degeneration of the Golgi and neuronal loss in dorsal root ganglia in diabetic BioBreeding/Worcester rats

1 reference

12 December 2020

Ultrastructure and cytochemistry of human cutaneous nerves. With special reference to the ultrastructural localization of the specific and nonspecific cholinesterases in human skin

1 reference

12 December 2020

Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction

1 reference

12 December 2020

Surrogate markers of small fiber damage in human diabetic neuropathy.

1 reference

12 December 2020

AMPK activation: a therapeutic target for type 2 diabetes?

1 reference

12 December 2020

Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart

1 reference

12 December 2020

AMP-activated protein kinase and its downstream transcriptional pathways

1 reference

12 December 2020

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

1 reference

12 December 2020

Mitochondrial loss indicates early axonal damage in small fiber neuropathies

1 reference

12 December 2020

Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies

1 reference

12 December 2020

Protective effects of peroxisome proliferator-activated receptors gamma coactivator-1alpha against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia.

1 reference

12 December 2020

Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?

1 reference

12 December 2020

Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia.

1 reference

12 December 2020

Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation

1 reference

12 December 2020

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

1 reference

12 December 2020

Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation

1 reference

12 December 2020

Neuropathology and pathogenesis of diabetic autonomic neuropathy

1 reference

12 December 2020

Mechanisms of distal axonal degeneration in peripheral neuropathies.

1 reference

12 December 2020

Impaired neurovascular repair in subjects with diabetes following experimental intracutaneous axotomy

1 reference

12 December 2020

Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats

1 reference

12 December 2020

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

1 reference

12 December 2020

Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs

1 reference

12 December 2020

Sensory neuropathy attributable to loss of Bcl-w

1 reference

12 December 2020

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

1 reference

12 December 2020

Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice

1 reference

12 December 2020

Histone deacetylases and their role in motor neuron degeneration

1 reference

12 December 2020

Mitochondria in the diabetic heart

1 reference

12 December 2020

Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats

1 reference

12 December 2020

Mitochondrial response to nutrient availability and its role in metabolic disease.

1 reference

12 December 2020

Neurotrophin-3 prevents mitochondrial dysfunction in sensory neurons of streptozotocin-diabetic rats

1 reference

12 December 2020

Mitotoxicity in distal symmetrical sensory peripheral neuropathies

1 reference

12 December 2020

Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes.

1 reference

12 December 2020

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

1 reference

12 December 2020

Supply and demand in cerebral energy metabolism: the role of nutrient transporters

1 reference

12 December 2020

Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways

1 reference

12 December 2020

Development of selective axonopathy in adult sensory neurons isolated from diabetic rats: role of glucose-induced oxidative stress

1 reference

12 December 2020

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

1 reference

12 December 2020

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

1 reference

12 December 2020

Light and electron microscopic distribution of nerve growth factor receptor-like immunoreactivity in the skin of the rat lower lip

1 reference

12 December 2020

Synaptic ultrastructural alterations anticipate the development of neuroaxonal dystrophy in sympathetic ganglia of aged and diabetic mice

1 reference

12 December 2020

Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.

1 reference

12 December 2020

Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia.

1 reference

12 December 2020

Mitochondrial stress and the pathogenesis of diabetic neuropathy

1 reference

12 December 2020

Balancing contractility and energy production: the role of myocyte enhancer factor 2 (MEF2) in cardiac hypertrophy

1 reference

12 December 2020

PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy.

1 reference

12 December 2020