(Q38588066)

4 September 2017

title

Microenvironment in metastasis: roadblocks and supportive niches (English)

1 reference

4 September 2017

Maren Pein

1

1 reference

4 September 2017

Thordur Oskarsson

series ordinal

2

1 reference

4 September 2017

publication date

16 September 2015

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American Journal of Physiology - Cell Physiology

4 September 2017

published in

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4 September 2017

volume

309

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4 September 2017

issue

10

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4 September 2017

page(s)

C627-38

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A CXCL1 paracrine network links cancer chemoresistance and metastasis

4 September 2017

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Genes that mediate breast cancer metastasis to the brain

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A pooled analysis of bone marrow micrometastasis in breast cancer

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Reactive gliosis and the multicellular response to CNS damage and disease.

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Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

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Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

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Diversity, topographic differentiation, and positional memory in human fibroblasts

21 January 2018

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The perivascular niche microenvironment in brain tumor progression

21 January 2018

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Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Molecular basis of metastasis.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

21 January 2018

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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.

21 January 2018

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Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics

21 January 2018

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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

High-throughput live-cell imaging reveals differential inhibition of tumor cell proliferation by human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Classifying collective cancer cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Metastasis prevention by targeting the dormant niche

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The perivascular niche regulates breast tumour dormancy.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Circulating tumor cells as a window on metastasis biology in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Natural History of Early, Localized Prostate Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Microenvironmental regulation of metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

21 January 2018

Fibroblasts in cancer

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

A multigenic program mediating breast cancer metastasis to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Dormancy of mammary carcinoma after mastectomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Real-time imaging reveals the single steps of brain metastasis formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Tumor self-seeding by circulating cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Framework models of tumor dormancy from patient-derived observations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Matrix crosslinking forces tumor progression by enhancing integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Interactions between cancer stem cells and their niche govern metastatic colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Genes that mediate breast cancer metastasis to lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Normal genetically mosaic mice produced from malignant teratocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Role of fibulin-5 in metastatic organ colonization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Metastasis: from dissemination to organ-specific colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Extracellular matrix components in breast cancer progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Metastatic stem cells: sources, niches, and vital pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Extracellular matrix players in metastatic niches

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The distribution of secondary growths in cancer of the breast. 1889

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

21 January 2018

Cancer micrometastases

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Tumour-educated macrophages promote tumour progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The metastatic niche: adapting the foreign soil

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Mechanisms of bone metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Cancer as an overhealing wound: an old hypothesis revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The metastatic niche and stromal progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Mechanisms of disseminated cancer cell dormancy: an awakening field

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Epithelial-mesenchymal transitions in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Tumor metastasis: molecular insights and evolving paradigms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Serpins promote cancer cell survival and vascular co-option in brain metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Origins of metastatic traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Cancer to bone: a fatal attraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Regulation of scar formation by vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Latent bone metastasis in breast cancer tied to Src-dependent survival signals

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

Is cancer a disease of self-seeding?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00145.2015

10.1152/AJPCELL.00145.2015

21 January 2018

Identifiers

DOI

1 reference

4 September 2017

1 reference