(Q38629870)

English

Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways

scientific article published on 19 March 2008

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scholarly article

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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Chris J Scotton

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Annette Gilchrist

4

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Rachel C. Chambers

5

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4 January 2020

author name string

Xiaoling Deng

1

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4 January 2020

Paul F Mercer

2

1 reference

Europe PubMed Central

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4 January 2020

publication date

19 March 2008

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Europe PubMed Central

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4 January 2020

Molecular Biology of the Cell

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

19

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

6

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

2520-2533

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

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Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury

1 reference

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A role for proteinase-activated receptor-1 in inflammatory bowel diseases

1 reference

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6 September 2017

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Role of coagulation cascade proteases in lung repair and fibrosis.

1 reference

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6 September 2017

Extracellular mediators in atherosclerosis and thrombosis: lessons from thrombin receptor knockout mice

1 reference

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6 September 2017

Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

The specificities of protein kinase inhibitors: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Rho GTPases in cell biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Lipid rafts and signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

The biological functions of A-kinase anchor proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Thrombin signalling and protease-activated receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Antagonists of the receptor-G protein interface block Gi-coupled signal transduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

The many faces of G protein signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Regulation of the MAP kinase cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

6 September 2017

PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

14 September 2017

Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

14 September 2017

Diversity in function and regulation of MAP kinase pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

14 September 2017

Design and use of C-terminal minigene vectors for studying role of heterotrimeric G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

25 September 2017

G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

25 September 2017

Heterotrimeric G proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

25 September 2017

Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

23 June 2018

Release of transforming growth factor-beta 1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2397294

23 June 2018

Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E07-07-0720

21 January 2018

Endothelial cytoskeletal reorganization in response to PAR1 stimulation is mediated by membrane rafts but not caveolae.

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E07-07-0720

21 January 2018

Altered vascular injury responses in mice deficient in protease-activated receptor-1.

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E07-07-0720

21 January 2018

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1 reference

https://api.crossref.org/works/10.1091%2FMBC.E07-07-0720

21 January 2018

The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E07-07-0720

21 January 2018

Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E07-07-0720

21 January 2018

Signaling mechanisms involved in protease-activated receptor-1-mediated interleukin-6 production by human gingival fibroblasts

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E07-07-0720

21 January 2018

The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice

1 reference

https://api.crossref.org/works/10.1091%2FMBC.E07-07-0720

21 January 2018

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18353977

12 December 2020

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inferred from PubMed ID database lookup

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Novel roles for chemokines and fibroblasts in interstitial fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18353977

12 December 2020

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inferred from PubMed ID database lookup

Thrombin Induces Proteinase-activated Receptor-1 Gene Expression in Endothelial Cells via Activation of Gi-linked Ras/Mitogen-activated Protein Kinase Pathway

1 reference

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Clinical significance of MCP-1 levels in BALF and serum in patients with interstitial lung diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18353977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18353977

12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18353977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1091/MBC.E07-07-0720

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

release_xztrp4lpsfcnzaqrubpnbi6vsa

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https://api.fatcat.wiki/v0/release/xztrp4lpsfcnzaqrubpnbi6vsa

24 November 2022

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18353977%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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