(Q38631279)

4 September 2017

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title

Clinical pharmacology of 5-fluorouracil (English)

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4 September 2017

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Diasio RB

1

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PubMed ID

2656050

4 September 2017

Harris BE

series ordinal

2

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4 September 2017

1 April 1989

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Clinical Pharmacokinetics

4 September 2017

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4 September 2017

16

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4 September 2017

215-237

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4 September 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003088-198916040-00002

4 September 2017

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cites work

The influence of cimetidine on the pharmacokinetics of 5-fluorouracil

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12 December 2020

Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase

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12 December 2020

Pharmacokinetic rationale for the interaction of 5-fluorouracil and misonidazole in humans

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12 December 2020

Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion

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12 December 2020

Dissociation of 5-fluorouracil-induced DNA fragmentation from either its incorporation into DNA or its cytotoxicity in murine T-lymphoma (S-49) cells

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12 December 2020

The effect of prednisolone and other factors on the catabolism of 5-fluorouracil in rats

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12 December 2020

N-chenodeoxycholyl-2-fluoro-beta-alanine: a biliary metabolite of 5-fluorouracil in humans

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12 December 2020

Biliary sclerosis in patients receiving hepatic arterial infusions of floxuridine

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12 December 2020

THE PHOTOCHEMISTRY OF 5-FLUOROURACIL

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12 December 2020

Protracted ambulatory venous infusion of 5-fluorouracil

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12 December 2020

Fluorouracil therapy in patients with carcinoma of the large bowel: a pharmacokinetic comparison of various rates and routes of administration

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12 December 2020

Inhibition of transfer RNA function by replacement of uridine and uridine-derived nucleosides with 5-fluorouridine

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12 December 2020

Studies on fluorinated pyrimidines. IX. The degradation of 5-fluorouracil-6-C14

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12 December 2020

Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil

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12 December 2020

DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair

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12 December 2020

Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy

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12 December 2020

Clinical pharmacology of hepatic arterial chemotherapy

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12 December 2020

Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography

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12 December 2020

The cell biology of multiple drug resistance

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12 December 2020

Cell surface alterations associated with exposure of leukemia L1210 cells to fluorouracil

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12 December 2020

Studies on fluorinated pyrimidines. XI. In vitro studies on tumor resistance

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12 December 2020

Nucleotide formation as adeterminant of 5-fluorouracil response in mouse leukemias

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12 December 2020

Circadian rhythm of rat liver dihydropyrimidine dehydrogenase. Possible relevance to fluoropyrimidine chemotherapy

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12 December 2020

Nonlinear pharmacokinetics for the elimination of 5-fluorouracil after intravenous administration in cancer patients

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12 December 2020

Biologic effect of 5-fluoro-2′-deoxyuridine incorporation in L1210 deoxyribonucleic acid

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12 December 2020

Quantitative analysis of 5-fluorouracil in human serum by selected ion monitoring gas chromatography--mass spectrometry

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12 December 2020

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

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12 December 2020

Cytotoxicity and the inhibition of ribosomal RNA processing in human colon carcinoma cells

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12 December 2020

DNA repair following incorporation of 5-fluorouracil into DNA of mouse bone marrow cells

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12 December 2020

The effect of leucovorin on the therapeutic index of fluorouracil in cancer patients

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12 December 2020

Hypoxic cell radiosensitizers as potential adjuvants to conventional chemotherapy for the treatment of cancer

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12 December 2020

Allopurinol modulation of high-dose fluorouracil toxicity

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12 December 2020

The co-purification and common identity of cholyl CoA:glycine- and cholyl CoA:taurine-N-acyltransferase activities from bovine liver

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12 December 2020

A mathematical model of the kinetics of 5-fluorouracil and its catabolites in freshly isolated rat hepatocytes.

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12 December 2020

Circadian pattern of continuous FUDR infusion reduces toxicities

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12 December 2020

On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice

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12 December 2020

Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer

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12 December 2020

Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism

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12 December 2020

The pharmacology of the fluoropyrimidines

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12 December 2020

Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism

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12 December 2020

Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid

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12 December 2020

Evidence from rat hepatocytes of an unrecognized pathway of 5-fluorouracil metabolism with the formation of a glucuronide derivative

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12 December 2020

Purification and properties of dihydrothymine dehydrogenase from rat liver

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12 December 2020

Combination chemotherapy: The interaction of methotrexate and 5-fluorouracil

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12 December 2020

Disposition of 5-fluorouracil after intravenous bolus doses of a commercial formulation to cancer patients

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12 December 2020

A basis for fluoropyrimidine-induced antagonism to methotrexate in Ehrlich ascites tumor cells in vitro

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12 December 2020

Nonlinear pharmacokinetic characteristics of 5-fluorouracil (5-FU) in colorectal cancer patients

1 reference

12 December 2020

Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites Tumours

1 reference

12 December 2020

Modulation of 5-fluorouracil catabolism in isolated rat hepatocytes with enhancement of 5-fluorouracil glucuronide formation

1 reference

12 December 2020

Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection

1 reference

12 December 2020

5-fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate-resistant KB cells

1 reference

12 December 2020

Fluoropyrimidine-mediated changes in small nuclear RNA

1 reference

12 December 2020

Kinetics and Mechanisms of Drug Action on Microorganisms XXIII: Microbial Kinetic Assay for Fluorouracil in Biological Fluids and Its Application to Human Pharmacokinetics

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12 December 2020

Degradation of pyrimidines and pyrimidine analogs--pathways and mutual influences

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12 December 2020

Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells

1 reference

12 December 2020

The toxicity of fluoroacetate and the tricarboxylic acid cycle. 1949.

1 reference

12 December 2020

Nonlinear pharmacokinetic models for 5-fluorouracil in man: intravenous and intraperitoneal routes

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12 December 2020

Toxicities and complications of implanted pump hepatic arterial and intravenous floxuridine infusion

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12 December 2020

5-Fluorouracil-metronidazole combination therapy in metastatic colorectal cancer. Clinical, pharmacokinetic and in vitro cytotoxicity studies

1 reference

12 December 2020

Schedule-dependent antitumor effects of methotrexate and 5-fluorouracil

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12 December 2020

The effect of 5-fluorouracil on DNA chain elongation in intact bone marrow cells.

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12 December 2020

Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion

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12 December 2020

5-Fluoro-2'-deoxyuridine incorporation in L1210 DNA

1 reference

12 December 2020

A sensitive method for determination of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in human plasma by high-pressure liquid chromatography

1 reference

12 December 2020

A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil

1 reference

12 December 2020

Comparative determinations of 5-fluorouracil in plasma using GC/MS and HPLC

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12 December 2020

Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil

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12 December 2020

Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion

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12 December 2020

Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients

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12 December 2020

1 reference

12 December 2020

DNA lesions in human neoplastic cells and cytotoxicity of 5-fluoropyrimidines

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12 December 2020

Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate

1 reference

12 December 2020

The use of intraperitoneal chemotherapy in the treatment of ovarian cancer

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12 December 2020

Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells

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12 December 2020

On the action of fluorouracil on leukemia cells

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12 December 2020

Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

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12 December 2020

Pharmacology of intraperitoneal infusion 5-fluorouracil and mitomycin-C

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12 December 2020

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile

1 reference

12 December 2020

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity

1 reference

12 December 2020

Effect of human renal and hepatic disease on the pharmacokinetics of anticancer drugs

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12 December 2020

Modulation of 5-fluorouracil toxicity by allopurinol in man

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12 December 2020

Clinical pharmacology of oral and intravenous 5-fluorouracil (NSC-19893).

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12 December 2020

5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling

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12 December 2020

Effect of 5-fluorouracil and thymidine on the transmembrane potential and zeta potential of HeLa cells

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12 December 2020

Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry

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12 December 2020

Plasma levels of 5-fluorouracil after oral and intravenous administration in cancer patients

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12 December 2020

Antineoplastic drugs: clinical pharmacology and therapeutic use.

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12 December 2020

Methods for thymidylate synthase pharmacodynamics: serial biopsy, free and total TS, FdUMP and dUMP, and H4PteGlu and CH2-H4PteGlu assays

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12 December 2020

Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.

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12 December 2020

Pharmacokinetics of fluorouracil in humans

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12 December 2020

Comparison of liquid- and gas-liquid chromatographic assays of 5-fluorouracil in plasma

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12 December 2020

Interaction between 5-fluorouracil and DNA of human colon adenocarcinoma

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12 December 2020

Reevaluation of the maximum tolerated dose of continuous venous infusion of 5-fluorouracil with pharmacokinetics

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12 December 2020

Lethality associated with incorporation of 5-fluorouracil into preribosomal RNA

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12 December 2020

Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas

1 reference

12 December 2020

Determination of 5-fluorouracil (NSC-19893) plasma levels in rats and man by isotope dilution-mass fragmentography

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12 December 2020

5-Fluoro-2′-Deoxyuridylate: Covalent Complex with Thymidylate Synthetase

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12 December 2020

Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase

1 reference

12 December 2020

Experience with continuous regional chemotherapy and hepatic resection as treatment of hepatic metastases from colorectal primaries. A prospective randomized study

1 reference

12 December 2020

Studies of a Mutation Affecting Pyrimidine Degradation in Inbred Mice

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12 December 2020

DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli

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12 December 2020

5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity

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12 December 2020

Effect of uracil on metabolism of 5-fluorouracil in vitro

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12 December 2020

Mechanism for exclusion of 5-fluorouracil from DNA

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12 December 2020

Nucleotide levels and incorporation of 5-fluorouracil and uracil into DNA of cells treated with 5-fluorodeoxyuridine

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12 December 2020

Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response

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12 December 2020

5-Fluorouracil incorporation in DNA of human breast carcinoma cells

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12 December 2020

Regional and systemic chemotherapy for colorectal metastases to the liver

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12 December 2020

Effects of 5-fluoro-2'-deoxyuridine on DNA metabolism in HeLa cells

1 reference

12 December 2020

Alteration of the secondary structure of newly synthesized DNA from murine bone marrow cells by 5-fluorouracil

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12 December 2020

Studies in 2-acetylaminofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma.

1 reference

12 December 2020

The combination of 5-fluorouracil with misonidazole in patients with advanced colorectal cancer

1 reference

12 December 2020

Studies on drug transport by normal human leukocytes

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12 December 2020

Enhancement of chemotherapy agents

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12 December 2020

Utilization of 5-fluoro-2'-deoxyuridine triphosphate and 5-fluoro-2'-deoxycytidine triphosphate in DNA synthesis by DNA polymerases alpha and beta from calf thymus

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12 December 2020

The incorporation of 5-fluoro-2'-deoxyuridine into DNA of mammalian tumor cells.

1 reference

12 December 2020

Determination of 5-fluorouracil in plasma by GC/MS using an internal standard. Applications to pharmacokinetics

1 reference

12 December 2020

Metabolism of 5-fluorouracil to an N-cholyl-2-fluoro-beta-alanine conjugate: previously unrecognized role for bile acids in drug conjugation

1 reference

12 December 2020

Permeability of Ehrlich Cells to Uracil, Thymine and Fluorouracil

1 reference

12 December 2020

Comparative physiologic dispositions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia

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12 December 2020

STUDIES ON RESISTANCE AGAINST 5-FLUOROURACIL. IV. EVIDENCE FOR AN ALTERED URIDINE KINASE IN RESISTANT CELLS.

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12 December 2020

Enzymes of uracil catabolism in normal and neoplastic human tissues

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12 December 2020

Partial purification and characterization of dihydropyrimidinases from calf and rat liver

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12 December 2020

The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase alpha in the metabolism of FUdR in human tumor cells

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12 December 2020

Advantages and limitations of pharmacokinetic studies in the rationalization of anticancer therapy: methotrexate and 5-FU.

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12 December 2020

Dihydrofluorouracil, a fluorouracil catabolite with antitumor activity in murine and human cells

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12 December 2020

THE PHYSIOLOGIC DISPOSITION OF 5-FLUOROURACIL AND 5-FLUORO-2'-DEOXYURIDINE IN MAN

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12 December 2020

Studies on resistance against 5-fluorouracil. I. Enzymes of the uracil pathway during development of resistance

1 reference

12 December 2020

Studies on fluorinated pyrimidines. X. In vivo studies on tumor resistance

1 reference

12 December 2020

10.2165/00003088-198916040-00002

Identifiers

DOI

1 reference

PubMed ID

2656050

Dimensions Publication ID

4 September 2017

0 references

1 reference

PubMed ID

2656050