(Q38631773)

English

The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase

scientific article published on 13 July 2011

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Statements

scholarly article

1 reference

Europe PubMed Central

4 September 2017

The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase (English)

1 reference

Europe PubMed Central

4 September 2017

Cytomegalovirus

0 references

author name string

Thomas Goldner

1

1 reference

Europe PubMed Central

4 September 2017

Guy Hewlett

2

1 reference

Europe PubMed Central

4 September 2017

Nicole Ettischer

3

1 reference

Europe PubMed Central

4 September 2017

Helga Ruebsamen-Schaeff

4

1 reference

Europe PubMed Central

4 September 2017

Holger Zimmermann

5

1 reference

Europe PubMed Central

4 September 2017

Peter Lischka

6

1 reference

Europe PubMed Central

4 September 2017

language of work or name

0 references

publication date

13 July 2011

1 reference

Europe PubMed Central

4 September 2017

Journal of Virology

1 reference

Europe PubMed Central

4 September 2017

85

1 reference

Europe PubMed Central

4 September 2017

10884-10893

1 reference

Europe PubMed Central

4 September 2017

20

1 reference

Europe PubMed Central

4 September 2017

Antiviral drug resistance of human cytomegalovirus

1 reference

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6 September 2017

New developments in the management of cytomegalovirus infection after solid organ transplantation

1 reference

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6 September 2017

International consensus guidelines on the management of cytomegalovirus in solid organ transplantation

1 reference

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Cytomegalovirus resistance testing: pitfalls and problems for the clinician

1 reference

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Retrograde axon transport of herpes simplex virus and pseudorabies virus: a live-cell comparative analysis

1 reference

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6 September 2017

Herpesvirus assembly: an update

1 reference

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6 September 2017

Drug targets in cytomegalovirus infection

1 reference

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6 September 2017

Antiviral strategies to combat cytomegalovirus infections in transplant recipients

1 reference

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6 September 2017

Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates

1 reference

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6 September 2017

Congenital cytomegalovirus (CMV) infection and hearing deficit

1 reference

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6 September 2017

Impact of 2-bromo-5,6-dichloro-1-beta-D-ribofuranosyl benzimidazole riboside and inhibitors of DNA, RNA, and protein synthesis on human cytomegalovirus genome maturation

1 reference

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6 September 2017

Cytomegalovirus

1 reference

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6 September 2017

Analysis of human cytomegalovirus oriLyt sequence requirements in the context of the viral genome

1 reference

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6 September 2017

Dramatic effects of 2-bromo-5,6-dichloro-1-beta-D-ribofuranosyl benzimidazole riboside on the genome structure, packaging, and egress of guinea pig cytomegalovirus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

Functional map of human cytomegalovirus AD169 defined by global mutational analysis

1 reference

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6 September 2017

A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

Human cytomegalovirus terminase as a target for antiviral chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

A novel transferable nuclear export signal mediates CRM1-independent nucleocytoplasmic shuttling of the human cytomegalovirus transactivator protein pUL69

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

A novel nonnucleoside inhibitor specifically targets cytomegalovirus DNA maturation via the UL89 and UL56 gene products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

The terminase subunits pUL56 and pUL89 of human cytomegalovirus are DNA-metabolizing proteins with toroidal structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

6 September 2017

Optimized recombinant dense bodies of human cytomegalovirus efficiently prime virus specific lymphocytes and neutralizing antibodies without the addition of adjuvant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

14 September 2017

The gene product of human cytomegalovirus open reading frame UL56 binds the pac motif and has specific nuclease activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

14 September 2017

In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

14 September 2017

The essential human cytomegalovirus gene UL52 is required for cleavage-packaging of the viral genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

14 September 2017

Interaction of the putative human cytomegalovirus portal protein pUL104 with the large terminase subunit pUL56 and its inhibition by benzimidazole-D-ribonucleosides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

14 September 2017

Analysis of the quaternary structure of the putative HCMV portal protein PUL104.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

14 September 2017

Interactions among antiviral drugs acting late in the replication cycle of human cytomegalovirus

1 reference

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Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action

1 reference

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25 September 2017

Insertion of an EYFP-pp71 (UL82) coding sequence into the human cytomegalovirus genome results in a recombinant virus with enhanced viral growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187482

23 June 2018

The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA.

1 reference

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23 June 2018

Design, synthesis, and antiviral activity of certain 2,5,6-trihalo-1-(beta-D-ribofuranosyl)benzimidazoles

1 reference

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23 June 2018

Leflunomide: a small step forward in meeting the urgent need for treatment of drug-resistant cytomegalovirus infection.

1 reference

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31 August 2018

Putative functional domains of human cytomegalovirus pUL56 involved in dimerization and benzimidazole D-ribonucleoside activity.

1 reference

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31 August 2018

UL74 of human cytomegalovirus contributes to virus release by promoting secondary envelopment of virions

1 reference

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31 August 2018

Deletion of open reading frame UL26 from the human cytomegalovirus genome results in reduced viral growth, which involves impaired stability of viral particles

1 reference

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31 August 2018

Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli

1 reference

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31 August 2018

High Frequency of Spontaneous Helicaseprimase Inhibitor (BAY 57–1293) Drug-Resistant Variants in Certain Laboratory Isolates of HSV-1

1 reference

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3 December 2018

Cytomegalovirus in hematopoietic stem cell transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21752907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First report of successful treatment of multidrug-resistant cytomegalovirus disease with the novel anti-CMV compound AIC246

1 reference

https://pubmed.ncbi.nlm.nih.gov/21752907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid microneutralization assay for the measurement of neutralizing antibody reactive with human cytomegalovirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21752907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: correlation with CMV disease and effect of ganciclovir prophylaxis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21752907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiviral treatment of cytomegalovirus infection and resistant strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/21752907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.05265-11

1 reference

Europe PubMed Central

4 September 2017

1 reference

Europe PubMed Central

4 September 2017

1 reference

Europe PubMed Central

4 September 2017

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