(Q38637632)

5 September 2017

title

Anti-DNA antibodies--quintessential biomarkers of SLE. (English)

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5 September 2017

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David S Pisetsky

1

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5 September 2017

language of work or name

English

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publication date

19 November 2015

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Nature Reviews Rheumatology

5 September 2017

published in

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5 September 2017

volume

12

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5 September 2017

issue

2

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5 September 2017

page(s)

102-110

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

5 September 2017

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Anti-DNA antibodies: aspects of structure and pathogenicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Systemic lupus erythematosus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Comparison of antibody repertoires produced by HIV-1 infection, other chronic and acute infections, and systemic autoimmune disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Mechanisms of B cell autoimmunity in SLE.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The use of laboratory tests in the diagnosis of SLE

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The anti-DNA antibody: origin and impact, dogmas and controversies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

A DNA-reacting factor in serum of a patient with lupus erythematosus diffusus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Complement fixation with cell nuclei and DNA in lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Secondary structure in denatured DNA is responsible for its reaction with antinative DNA antibodies of systemic lupus erythematosus sera

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Standardization of anti-DNA antibody assays

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Chromatin: constructing the big picture

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The nucleosome: from genomic organization to genomic regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Structural dynamics of nucleosomes at single-molecule resolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisolone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Antinucleosome antibodies as a marker of active proliferative lupus nephritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The spectrum of anti-chromatin/nucleosome autoantibodies: independent and interdependent biomarkers of disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Review: antinucleosome antibodies: a critical reflection on their specificities and diagnostic impact

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Circulating nucleic acids in plasma/serum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Cell-free nucleic acids as biomarkers in cancer patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The origin and properties of extracellular DNA: from PAMP to DAMP.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The translocation of nuclear molecules during inflammation and cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Analysing cell-free plasma DNA and SLE disease activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Elevated plasma cfDNA may be associated with active lupus nephritis and partially attributed to abnormal regulation of neutrophil extracellular traps (NETs) in patients with systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Anti-dsDNA antibodies as a classification criterion and a diagnostic marker for systemic lupus erythematosus: critical remarks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Comparison of three anti-dsDNA assays: performance and correlation with systemic lupus erythematosus disease activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Four Anti-dsDNA Antibody Assays in Relation to Systemic Lupus Erythematosus Disease Specificity and Activity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Immunology of DNA. II. The effect of size and structure of the antigen on the farr assay

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Changes in Farr radioimmunoassay and EliA fluorescence immunoassay anti-dsDNA in relation to exacerbation of SLE.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The influence of polyvalency on the binding properties of antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The Shape of Immunoglobulin G Molecules in Solution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Reaction of systemic lupus erythematosus antinative DNA antibodies with native DNA fragments from 20 to 1,200 base pairs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Binding of monoclonal anti-native DNA autoantibodies to DNA of varying size and conformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The influence of DNA size on the binding of anti-DNA antibodies in the solid and fluid phase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

DNA/anti-DNA complexes: correlation of size and complement fixation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Genetic and structural evidence for antigen selection of anti-DNA antibodies.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Binding properties of human anti-DNA antibodies to cloned human DNA fragments

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Selective binding of anti-DNA antibodies to native dsDNA fragments of differing sequence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Characterization of antibodies to bacterial double-stranded DNA in the sera of normal human subjects.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Antibodies to dsDNA are produced during primary BK virus infection in man, indicating that anti-dsDNA antibodies may be related to virus replication in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The binding of sera of patients with SLE to bacterial and mammalian DNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The effect of polyamines on the binding of anti-DNA antibodies from patients with SLE and normal human subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Antibodies to polynucleotides in human sera: antigenic specificity and relation to disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Circulating DNA:anti-DNA complexes in systemic lupus erythematosus. Detection and characterization by ultracentrifugation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

DNA levels in circulating immune complexes decrease at severe SLE flares-correlation with complement component C1q

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Lupus nephritis: enigmas, conflicting models and an emerging concept

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Glomerular Autoimmune Multicomponents of Human Lupus Nephritis In Vivo (2): Planted Antigens.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Exposure of chromatin and not high affinity for dsDNA determines the nephritogenic impact of anti-dsDNA antibodies in (NZBxNZW)F1 mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature in murine lupus nephritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Molecular basis of DNA recognition in the immune system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Recognition of cytosolic DNA by cGAS and other STING-dependent sensors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Regulation of the interferon-alpha production induced by RNA-containing immune complexes in plasmacytoid dendritic cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Human lupus autoantibodies against NMDA receptors mediate cognitive impairment.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Anti-dsDNA and Antichromatin Antibody Isotypes in Serologically Active Clinically Quiescent Systemic Lupus Erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Use of a novel elution regimen reveals the dominance of polyreactive antinuclear autoantibodies in lupus kidneys

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

The complement system in systemic lupus erythematosus: an update

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Cell-bound complement activation products in systemic lupus erythematosus: comparison with anti-double-stranded DNA and standard complement measurements

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Distinct features of circulating microparticles and their relationship to clinical manifestations in systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Galectin-3 binding protein links circulating microparticles with electron dense glomerular deposits in lupus nephritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Ro/SS-A and La/SS-B antibody level variation in patients with Sjögren's syndrome and systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Serial analysis of Ro/SSA and La/SSB antibody levels and correlation with clinical disease activity in patients with systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Are autoantibodies the targets of B-cell-directed therapy?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Cytokine induction by circulating immune complexes and signs of in-vivo complement activation in systemic lupus erythematosus are associated with the occurrence of anti-Sjögren's syndrome A antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Autoantibodies associated with RNA are more enriched than anti-dsDNA antibodies in circulating immune complexes in SLE

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2015.151

Specific detection of circulating DNA:anti-DNA immune complexes in human systemic lupus erythematosus sera using murine monoclonal anti-DNA antibody

31 March 2020

1 reference

12 December 2020

Deficient expression of antibodies specific for bacterial DNA by patients with systemic lupus erythematosus

1 reference

12 December 2020

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays

1 reference

12 December 2020

Monogamous bivalency of IgG antibodies. I. Deficiency of branched ABHI-active oligosaccharide chains on red cells of infants causes the weak antiglobulin reactions in hemolytic disease of the newborn due to ABO incompatibility

1 reference

12 December 2020

The Specificity and Applications of Antibodies to Helical Nucleic Acid

1 reference

12 December 2020

DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells.

1 reference

12 December 2020

Residues that mediate DNA binding of autoimmune antibodies

1 reference

12 December 2020

New serological methods for the detection of the L.E. factor

1 reference

12 December 2020

Spontaneous expression of antibodies to DNA of various species origin in sera of normal subjects and patients with systemic lupus erythematosus

1 reference

12 December 2020

Antidouble stranded DNA antibody assays in systemic lupus erythematosus: correlations of longitudinal antibody measurements

1 reference

12 December 2020

Systemic lupus erythematosus: prototype of immune complex nephritis in man.

1 reference

12 December 2020

Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus

1 reference

12 December 2020

Studies of the physical biochemistry and complement-fixing properties of DNA/anti-DNA immune complexes

1 reference

12 December 2020

Independent expression of autoantibodies in systemic lupus erythematosus

1 reference

12 December 2020

Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus.

1 reference

12 December 2020

Dna isolated from DNA/anti-DNA antibody immune complexes in systemic lupus erythematosus is rich in guanine-cytosine content

1 reference

12 December 2020

On the biological origin of anti-double-stranded (ds) DNA antibodies: systemic lupus erythematosus-related anti-dsDNA antibodies are induced by polyomavirus BK in lupus-prone (NZBxNZW) F1 hybrids, but not in normal mice

1 reference

12 December 2020

Correlation between clinical activity of systemic lupus erythematosus and the amounts of DNA in DNA/anti-DNA antibody immune complexes

1 reference

12 December 2020

[Demonstration in the blood of patients with disseminated lupus erythematosus a substance determining a precipitation reaction with desoxyribonucleic acid]

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2015.151

1 reference

Dimensions Publication ID

5 September 2017

1040701685

0 references

1 reference