(Q38657879)

5 September 2017

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title

Clinical pharmacokinetics of epidural and spinal anaesthesia (English)

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5 September 2017

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Burm AG

1

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5 September 2017

1 May 1989

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Clinical Pharmacokinetics

5 September 2017

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5 September 2017

16

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5 September 2017

5

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5 September 2017

283-311

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https://scigraph.springernature.com/pub.10.2165/00003088-198916050-00002

5 September 2017

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cites work

Is plasma binding of local anesthetics important?

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12 December 2020

Absorption of Lidocaine following Subarachnoid and Epidural Administration

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12 December 2020

A double-blind study of motor blockade in the lower limbs. Studies during spinal anaesthesia with hyperbaric and glucose-free 0.5% bupivacaine.

1 reference

12 December 2020

The effects of subarachnoid lidocaine and phenylephrine on spinal cord and cerebral blood flow in dogs.

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12 December 2020

The pH of local anesthetic solutions.

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12 December 2020

Spinal anesthesia with tetracaine--effect of added vasoconstrictors.

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12 December 2020

Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds.

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12 December 2020

Plasma concentrations of lidocaine and its principal metabolites during intermittent epidural anesthesia.

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12 December 2020

Subarachnoid anaesthesia with 0.5% bupivacaine: effects of density.

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12 December 2020

Prolonged neural blockade following regional analgesia with 2-chloroprocaine

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12 December 2020

Effect of increasing amounts of epinephrine during isobaric bupivacaine spinal anesthesia in elderly patients.

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12 December 2020

Lack of influence of cimetidine on bupivacaine levels during parturition.

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12 December 2020

Age and the spread of local anesthetic solutions in the epidural space.

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12 December 2020

Plasma lidocaine concentrations after caudal, lumbar epidural, axillary block, and intravenous regional anesthesia.

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12 December 2020

Comparison of pH-adjusted lidocaine solutions for epidural anesthesia.

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12 December 2020

Subarachnoid anaesthesia produced by hyperbaric lignocaine in elderly patients. Prolongation of effect with adrenaline

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12 December 2020

Lower limb reflex changes in segmental epidural analgesia

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12 December 2020

Spinal cord blood flow following sub-arachnoid lidocaine.

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12 December 2020

Distribution of local anesthetic solutions within the subarachnoid space.

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12 December 2020

Toxic effects of local anaesthetic agents on the central nervous system.

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12 December 2020

The effect of subarachnoid epinephrine and phenylephrine on spinal cord blood flow

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12 December 2020

Comparison of neural blockade and pharmacokinetics after subarachnoid lidocaine in the rhesus monkey. II: Effects of volume, osmolality, and baricity.

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12 December 2020

Accumulation of mepivacaine hydrochloride during caudal block.

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12 December 2020

Local anaesthetics and their current clinical use.

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12 December 2020

Epinephrine enhances analgesia produced by epidural bupivacaine during labor.

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12 December 2020

Plasma levels of 2-chloroprocaine in obstetric patients and their neonates after epidural anesthesia.

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12 December 2020

Persistent neurologic deficit and adhesive arachnoiditis following intrathecal 2-chloroprocaine injection

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12 December 2020

Transport of propranolol and lidocaine through the rat blood-brain barrier. Primary role of globulin-bound drug

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12 December 2020

Pharmacology of local anaesthetic agents. Pharmacokinetics of local anaesthetic agents

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12 December 2020

The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia II: Pharmacokinetics

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12 December 2020

Effect of pregnancy on bupivacaine-induced conduction blockade in the isolated rabbit vagus nerve.

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12 December 2020

Spinal cord and cerebral blood flow responses to subarachnoid injection of local anesthetics with and without epinephrine

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12 December 2020

Chloroprocaine neurotoxicity: four additional cases.

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12 December 2020

Spinal analgesia with hyperbaric bupivacaine: influence of age.

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12 December 2020

Pharmacokinetics of local anaesthetics

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12 December 2020

Safety and efficacy of epinephrine added to bupivacaine for lumbar epidural analgesia in obstetrics.

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12 December 2020

Vasoconstrictors in spinal anesthesia with tetracaine--a comparison of epinephrine and phenylephrine

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12 December 2020

The fate of intrathecal procaine and the spinal fluid level required for surgical anesthesia.

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12 December 2020

Lung Uptake of Lidocaine in Healthy Volunteers

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12 December 2020

Bupivacaine in children: pharmacokinetics following caudal anesthesia.

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12 December 2020

Concentrations of Bupivacaine in the CSF following subdural application (author's transl)

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12 December 2020

The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents. II.

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12 December 2020

Plasma bupivacaine concentrations in children during caudal epidural analgesia.

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12 December 2020

Neural blockade and pharmacokinetics following subarachnoid lidocaine in the rhesus monkey. I. Effects of epinephrine.

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12 December 2020

Hemodynamic drug interaction: peridural lidocaine and intravenous ephedrine.

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12 December 2020

Age and epidural dose response in adult men.

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12 December 2020

Effect of intrathecal bupivacaine on somatosensory evoked potentials following dermatomal stimulation.

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12 December 2020

Spinal cord blood flow during spinal anesthesia in dogs: the effects of tetracaine, epinephrine, acute blood loss, and hypercapnia

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12 December 2020

[Blood and cerebrospinal fluid levels of bupivacaine in spinal anesthesia]

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12 December 2020

Propranolol reduces bupivacaine clearance.

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12 December 2020

Spinal cord effects of epinephrine.

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12 December 2020

Systemic absorption of mepivacaine in commonly used regional block procedures.

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12 December 2020

Observed and predicted accumulation of local anaesthetic agents during continuous extradural analgesia

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12 December 2020

Binding of anilide-type local anesthetics in human plasma. I. Relationships between binding, physicochemical properties, and anesthetic activity.

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12 December 2020

The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents. I. An experimental study in cats.

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12 December 2020

Postoperative pain prevention by continuous epidural infusion. A study of the clinical effects and the plasma concentrations obtained.

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12 December 2020

Differential effect of plasma protein binding of bupivacaine on its in vivo transfer into the brain and salivary gland of rats.

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12 December 2020

Local anaesthetic plasma levels in children

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12 December 2020

Increased brain uptake of lidocaine during bicuculline-induced status epilepticus in rats.

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12 December 2020

Epidural anesthesia with lidocaine and bupivacaine: effects of epinephrine on the plasma concentration profiles.

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12 December 2020

H2 antagonists and bupivacaine clearance.

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12 December 2020

Comparative maternal, fetal, and neonatal effects of chloroprocaine with and without epinephrine for epidural anesthesia in obstetrics.

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12 December 2020

Effects of concentration of local anaesthetic drugs in extradural block.

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12 December 2020

A dose-response study of bupivacaine for spinal anesthesia.

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12 December 2020

Alpha 1-acid glycoprotein and albumin in human serum bupivacaine binding.

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12 December 2020

Effects of beta-adrenoceptor antagonists on the pharmacokinetics of lignocaine

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12 December 2020

Bupivacaine levels in plasma and cerebrospinal fluid following peridural administration.

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12 December 2020

Extradural analgesia revisited. A statistical study.

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12 December 2020

Venous blood concentrations after subarachnoid administration of bupivacaine.

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12 December 2020

Epidural anesthesia with bupivacaine: effects of age on neural blockade and pharmacokinetics.

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12 December 2020

An intradermal study of the local anaesthetic and vascular effects of the isomers of bupivacaine

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12 December 2020

Plasma drug binding: implications for anesthesiologists

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12 December 2020

Pharmacokinetics and neural blockade after subarachnoid lidocaine in the rhesus monkey. III. Effects of phenylephrine.

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12 December 2020

Pharmacology of local anaesthetic agents

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12 December 2020

Circulatory effects of peridural block. IV. Comparison of the effects of epinephrine and phenylephrine

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12 December 2020

Adverse effects of local anaesthetics

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12 December 2020

Citanest...a clinical and laboratory study. 1.

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12 December 2020

Evaluation of the toxicity of local anaesthetic agents in man

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12 December 2020

Bupivacaine-induced cardiac arrhythmias in sheep.

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12 December 2020

COMPARATIVE EVALUATION IN PERIDURAL ANESTHESIA OF LIDOCAINE, MEPIVACAINE AND L-67, A NEW LOCAL ANESTHETIC AGENT.

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12 December 2020

Pharmacokinetics of Intravenous Procaine Infusion in Humans

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12 December 2020

Local anesthetic drugs: penetration from the spinal extradural space into the neuraxis.

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12 December 2020

Bupivacaine carbonate and bupivacaine hydrochloride: a comparison of blood concentrations during epidural blockade for vaginal surgery.

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12 December 2020

Peripheral neurotoxicity of 2-chloroprocaine and bisulfite in the cat.

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12 December 2020

Epidural anesthetic dose responses in patients 20 to 80 years old.

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12 December 2020

A double-blind comparison of carbonated lidocaine and lidocaine hydrochloride in epidural anaesthesia.

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12 December 2020

Pharmacokinetics of lidocaine and bupivacaine following subarachnoid administration in surgical patients: simultaneous investigation of absorption and disposition kinetics using stable isotopes.

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12 December 2020

Effects of posture on the spread of isobaric and hyperbaric amethocaine.

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12 December 2020

QUALITY OF EPIDURAL BLOCKADE. I. INFLUENCE OF PHYSICAL FACTORS

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12 December 2020

Comparison of carbonated bupivacaine and bupivacaine hydrochloride for extradural anaesthesia.

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12 December 2020

Effects of H-2 antagonists on the elimination of bupivacaine.

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12 December 2020

Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans

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12 December 2020

Hepatic clearance of local anesthetics in man.

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12 December 2020

Clinical Effects of Carticaine, a New Local Anesthetic. A Survey and a Double-Blind Investigation Comparing Carticaine with Lidocaine in Epidural Analgesia

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12 December 2020

Effect of adrenaline on the systemic absorption of local anaesthetic drugs.

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12 December 2020

Evaluation of etidocaine in extradural block

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12 December 2020

Comparison of bupivacaine and etidocaine in extradural blockade

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12 December 2020

Bupivacaine for intercostal nerve blocks in children: blood concentrations and pharmacokinetics

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12 December 2020

Caudal anesthesia with lidocaine or bupivacaine: plasma local anesthetic concentration and extent of sensory spread in old and young patients.

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12 December 2020

Lung uptake of lidocaine in man as influenced by anaesthesia, mepivacaine infusion or lung insufficiency.

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12 December 2020

Subarachnoid bupivacaine decreases spinal cord blood flow in dogs.

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12 December 2020

Pharmacokinetic Aspects of Intravenous Regional Anesthesia

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12 December 2020

Determinants of Etidocaine Concentration in the Blood

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12 December 2020

Effect of epidural bupivacaine on somatosensory evoked potentials after dermatomal stimulation.

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12 December 2020

Clinical pharmacokinetics of local anaesthetics.

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12 December 2020

Differential neural effects of epidural anesthetics.

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12 December 2020

Differential sensitivities of mammalian nerve fibers during pregnancy.

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12 December 2020

Differential sensitivity of fast and slow fibers in mammalian nerve. III. Effect of etidocaine and bupivacaine on fast/slow fibers

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12 December 2020

Spinal analgesia using bupivacaine 0·5% plain Variation in the extent of the block with patient age

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12 December 2020

Spinal analgesia with bupivacaine, mepivacaine and tetracaine.

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12 December 2020

Plasma levels of 2-chloroprocaine and lack of sequelae following an apparent inadvertent intravenous injection.

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12 December 2020

Studies on the absorption, distribution and metabolism of labelled prilocaine and lidocaine in some animal species.

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12 December 2020

Blood Concentration of Lidocaine after Spinal Anaesthesia Using Lidocaine and Lidocaine with Adrenaline

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12 December 2020

Plasma concentrations of lidocaine and bupivacaine after subarachnoid administration.

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12 December 2020

The rate of procaine hydrolysis in serum of normal subjects and diseased patients.

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12 December 2020

Thoracic Epidural Analgesia —II: Prolongation in the Early Postoperative Period by Continuous Injection of 1.0% Bupivacaine

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12 December 2020

Does spinal anesthesia anesthetize the spinal cord?

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12 December 2020

Spinal anaesthesia with hyperbaric tetracaine: effect of age and body mass

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12 December 2020

Distribution of Local Anesthetics in Man Following Peridural Anesthesia

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12 December 2020

[Comparative studies on the blood level of mepivacaine following f resorption from various tissues]

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12 December 2020

Epinephrine prolongs lidocaine spinal: pain in the operative site the most accurate method of determining local anesthetic duration.

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12 December 2020

Lidocaine constricts or dilates rat arterioles in a dose-dependent manner.

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12 December 2020

Bupivacaine disposition in mother, fetus, and neonate after spinal anesthesia for cesarean section.

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12 December 2020

Pharmacokinetics of lignocaine and bupivacaine in surgical patients following epidural administration. Simultaneous investigation of absorption and disposition kinetics using stable isotopes.

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12 December 2020

Etidocaine: clinical evaluation for intercostal nerve block and lumbar epidural block

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12 December 2020

Factors influencing serum protein binding of lidocaine in humans.

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12 December 2020

Altered neural conduction with epidural bupivacaine.

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12 December 2020

Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers.

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12 December 2020

An intradermal study of the local anaesthetic and vascular effects of the isomers of mepivacaine

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12 December 2020

A correlation of the differential penetration and the systemic toxicity of lidocaine, mepivacaine and prilocaine in man.

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12 December 2020

Motor paralysis increases brain uptake of lidocaine during status epilepticus.

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12 December 2020

Dose-dependent effects of bupivacaine on rat muscle arterioles.

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12 December 2020

Spinal anaesthesia with hyperbaric bupivacaine. Effects of age on neural blockade and pharmacokinetics.

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12 December 2020

The effect of mepivacaine and lidocaine on forearm resistance and capacitance vessels in man

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12 December 2020

Quality of epidural blockade. 3. Carbonated local anaesthetic solutions.

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12 December 2020

Bupivacaine binding to plasma protein fractions

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12 December 2020

Lidocaine and bupivacaine mixtures for epidural blockade.

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12 December 2020

Obstetric analgesia. Clinical pharmacokinetic considerations

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12 December 2020

Spinal anesthesia with glucose-free bupivacaine: effects of age on neural blockade and pharmacokinetics.

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12 December 2020

THE INTRAVENOUS TOXICITY OF LOCAL ANESTHETIC AGENTS IN MAN.

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12 December 2020

Maternal, fetal, and neonatal effects of lidocaine with and without epinephrine for epidural anesthesia in obstetrics.

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12 December 2020

The impairment of lignocaine clearance by propranolol--major contribution from enzyme inhibition

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12 December 2020

Effects of adrenaline and the concentration of solution on extradural block with etidocaine

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12 December 2020

Clinical observations suggesting a changing site of action during induction and recession of spinal and epidural anesthesia.

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12 December 2020

THE SYSTEMIC ABSORPTION OF LOCAL ANALGESIC DRUGS

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12 December 2020

Role of epinephrine in regional block anesthesia with etidocaine: a double-blind study

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12 December 2020

Uptake and elimination of local anesthetics during spinal anesthesia

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12 December 2020

Influence of age on spinal anaesthesia with isobaric 0.5% bupivacaine.

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12 December 2020

Effect of baricity on spinal anaesthesia with amethocaine.

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12 December 2020

Plasma concentrations of lidocaine associated with cervical, thoracic, and lumbar epidural anesthesia.

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12 December 2020

Effect of added epinephrine on spinal anesthesia with lidocaine.

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12 December 2020

The spread of lidocaine and I-131 solution in the epidural space

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12 December 2020

Prolongation of isobaric bupivacaine spinal anesthesia with epinephrine and clonidine for hip surgery in the elderly.

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12 December 2020

Epinephrine does not prolong lidocaine spinal anesthesia in term parturients.

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12 December 2020

A sheep preparation for studying interactions between blood flow and drug disposition. II: Experimental applications.

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12 December 2020

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12 December 2020

A comparison of intravenous and subarachnoid lidocaine pharmacokinetics in the rhesus monkey.

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12 December 2020

Comparison of the clinical effectiveness of lidocaine hydrocarbonate and lidocaine hydrochloride with and without epinephrine in epidural anaesthesia.

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12 December 2020

Kinetics of local anesthetic esters and the effects of adjuvant drugs on 2-chloroprocaine hydrolysis.

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12 December 2020

Spinal cord blood flow following subarachnoid tetracaine.

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12 December 2020

Blood concentrations of lidocaine, mepivacaine and bupivacaine during caudal analgesia in children.

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12 December 2020

A comparison of the hydrochloride and carbonated salts of lignocaine for caudal analgesia in out-patients

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12 December 2020

Local spinal cord blood flow and glucose utilization during spinal anesthesia with bupivacaine in conscious rats

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12 December 2020

Spread of analgesic solutions in the epidural space and their site of action: a statistical study.

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12 December 2020

The spread of solutions injected into the epidural space. A study using epidurograms in patients with the lumbosciatic syndrome.

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12 December 2020

The pharmacokinetics and metabolism of the anilide local anaesthetics in neonates. III. Mepivacaine.

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12 December 2020

Grand mal seizures after 2-chloroprocaine epidural anesthesia in a patient with plasma cholinesterase deficiency

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12 December 2020

Effects of patient age, pH of cerebrospinal fluid, and vasopressors on onset and duration of spinal anesthesia

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12 December 2020

The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia I: block characteristics and cardiovascular effects

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12 December 2020

Pharmacokinetics of bupivacaine following caudal anesthesia in infants.

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12 December 2020

Distribution of Local Anesthetic Agents in the Neuraxis of the Dog

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12 December 2020

Influence of intravenously administered ephedrine on splanchnic haemodynamics and clearance of lidocaine

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12 December 2020

Ageing and epidural dose requirements: segmental spread and predictability of epidural analgesia in youth and extreme age

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12 December 2020

Effects of smoking and chronic hepatitis B on lidocaine and indocyanine green kinetics.

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12 December 2020

Spinal anesthesia with hyperbaric lidocaine and bupivacaine: effects of epinephrine on the plasma concentration profiles.

1 reference

12 December 2020

Spinal anesthesia with hyperbaric bupivacaine: effect of added vasoconstrictors.

1 reference

12 December 2020

[Effect of glucose concentration in bupivacaine solutions on the distribution of local anesthetics in cerebrospinal fluid during spinal anesthesia]

1 reference

12 December 2020

METABOLISM OF PROCAINE IN CEREBROSPINAL FLUID CONTAMINATED WITH BLOOD.

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12 December 2020

The pharmacokinetics and metabolism of the anilide local anaesthetics in neonates. I. Lignocaine.

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12 December 2020

Spinal anesthesia: bupivacaine compared with tetracaine.

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12 December 2020

Factors affecting plasma levels of lignocaine and prilocaine

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12 December 2020

A sheep preparation for studying interactions between blood flow and drug disposition. III: Effects of general and spinal anaesthesia on regional blood flow and oxygen tensions.

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12 December 2020

Blood levels of mepivacaine during continuous epidural anesthesia.

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12 December 2020

Influence of age on vascular absorption of lidocaine from the epidural space

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12 December 2020

The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep

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12 December 2020

Intrathecal and epidural administration of opioids

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12 December 2020

Differential nerve blocking activity of amino-ester local anaesthetics.

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12 December 2020

The effect of concentration on vasoactivity of bupivacaine and lignocaine

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12 December 2020

Cardiovascular pharmacology of local anaesthetics

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12 December 2020

Effect of thoracic epidural bupivacaine on somatosensory evoked potentials after dermatomal stimulation.

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12 December 2020

The spread of drugs used for spinal anesthesia.

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12 December 2020

Effect of Epinephrine Concentration on Lidocaine Disposition during Epidural Anesthesia

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12 December 2020

Arterial and venous plasma levels of bupivacaine following epidural and intercostal nerve blocks

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12 December 2020

Pharmacokinetic and clinical pharmacological studies with mepivacaine and prilocaine

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12 December 2020

Lumbar Epidural Anaesthesia With Bupivacaine in Old Patients: Effect of Speed and Direction of Injection

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12 December 2020

Etidocaine--a new long-acting anesthetic agent: a clinical evaluation

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12 December 2020

Pharmacokinetics of lignocaine in children following caudal anaesthesia.

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12 December 2020

Simultaneous Systemic and Hepatic Hemodynamic Measurements During High Peridural Anesthesia In Normal Man

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12 December 2020

Epidural blockade for cesarean section comparing lidocaine hydrocarbonate and lidocaine hydrochloride.

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12 December 2020

Mechanism of action of extradural analgesia

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12 December 2020

Disposition and placental transfer of etidocaine in pregnancy

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12 December 2020

Bupivacaine and Other Amide Local Anesthetics Inhibit the Hydrolysis of Chloroprocaine by Human Serum

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12 December 2020

Effect of adrenaline on extradural anaesthesia and plasma bupivacaine concentrations during caesarean section

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12 December 2020

Influence of viral hepatitis on the disposition of two compounds with high hepatic clearance: lidocaine and indocyanine green

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12 December 2020

Prolongation of lidocaine spinal anesthesia with epinephrine and phenylephrine.

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12 December 2020

Lidocaine plasma protein binding.

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12 December 2020

Effect of pH-adjustment of bupivacaine on onset and duration of epidural analgesia in parturients

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12 December 2020

Differential sensitivities of mammalian nerve fibers to local anesthetic agents.

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12 December 2020

10.2165/00003088-198916050-00002

Identifiers

DOI

1 reference

PubMed ID

2663301

Dimensions Publication ID

5 September 2017

0 references

1 reference

PubMed ID

2663301