(Q38658263)

5 September 2017

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title

Labetalol. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in hypertension and ischaemic heart disease (English)

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5 September 2017

arterial hypertension

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Goa KL

1

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5 September 2017

Benfield P

series ordinal

2

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5 September 2017

Sorkin EM

series ordinal

3

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5 September 2017

language of work or name

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1 May 1989

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5 September 2017

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5 September 2017

37

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5 September 2017

583-627

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5 September 2017

5

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https://scigraph.springernature.com/pub.10.2165/00003495-198937050-00002

5 September 2017

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cites work

Pharmacological effects of labetalol in man

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12 December 2020

Labetalol compared with propranolol in the treatment of black hypertensive patients

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12 December 2020

Metabolism of labetalol by animals and man.

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12 December 2020

Determination of labetalol in human plasma by high-performance liquid chromatography

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12 December 2020

IV. Labetalol in the management of severe hypertension

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12 December 2020

Labetalol in the treatment of hypertension in elderly and younger patients

1 reference

12 December 2020

Monotherapy with labetalol in the treatment of mild hypertension: A double-blind study

1 reference

12 December 2020

Intravenous labetalol and intravenous diazoxide in severe hypertension complicating pregnancy

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12 December 2020

Intrinsic activity of labetalol on guinea-pig isolated trachea

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12 December 2020

LABETALOL AND PLATELET FUNCTION IN PRE-ECLAMPSIA

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12 December 2020

The effects of enzyme induction and enzyme inhibition on labetalol pharmacokinetics

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12 December 2020

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12 December 2020

The evaluation of labetalol in the treatment of hypertension complicating pregnancy

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12 December 2020

Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy.

1 reference

12 December 2020

Comparative trial of labetalol and acebutolol, alone or associated with dihydralazine, in treatment of essential hypertension

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12 December 2020

Short- and long-term (six-year) hemodynamic effects of labetalol in essential hypertension.

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12 December 2020

Labetalol steady-state pharmacokinetics in hypertensive patients

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12 December 2020

Controlled comparison of labetalol and propranolol in the management of severe hypertension

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12 December 2020

Haemodynamic effects of intravenous labetalol in hypertensive patients with obstructive coronary heart disease complicated by acute myocardial infarction of recent origin

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12 December 2020

Acute effect of an antihypertensive drug, labetalol, on uteroplacental blood flow.

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12 December 2020

Elimination kinetics of labetalol in severe renal failure

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12 December 2020

Effects of combined alpha- and beta-blockade by labetalol in patients with coronary artery disease

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12 December 2020

A review of the animal pharmacology of labetalol, a combined alpha- and beta-adrenoceptor-blocking drug

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12 December 2020

Effects of atenolol, labetalol and propranolol on the peripheral circulation in hypertensive patients without obstructive vascular disease

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12 December 2020

Antihypertensive therapy with diuretics and beta-blockers at fixed dosage: comparison between the combinations labetalol plus chlorthalidone and atenolol plus chlorthalidone

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12 December 2020

Comparison of antihypertensive efficacy and perinatal safety of labetalol and methyldopa in the treatment of hypertension in pregnancy: a randomized controlled trial

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12 December 2020

Use of labetalol in the treatment of severe hypertension during pregnancy

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12 December 2020

Comparison of the Effects of Labetalol and Hydrochlorothiazide on the Ventilatory Function of Hypertensive Patients with Asthma and Propranolol Sensitivity

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12 December 2020

Interaction of clonidine and labetalol in hypertension

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12 December 2020

Proceedings: The effects of AH 5158 on the overflow of transmitter and the uptake of (3H)-(--)-noradrenaline in the cat spleen

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12 December 2020

Systemic, pulmonary, and coronary hemodynamic effects of labetalol in hypertensive subjects.

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12 December 2020

Acute effect of labetalol on hypertensive brachial artery.

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12 December 2020

Treatment of severe hypertension with labetalol compared with methyldopa and furosemide. Results of a long-term, double-blind, multicenter trial

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12 December 2020

Labetalol to control blood pressure after cerebrovascular surgery

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12 December 2020

Labetalol as monotherapy in hypertensive black patients.

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12 December 2020

The treatment of hypertension by labetalol--a new alpha- and beta-adrenoreceptor blocking agent

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12 December 2020

Effect of food on the bioavailability of labetalol

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12 December 2020

Bullous lichen planus caused by labetalol

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12 December 2020

Transfer of labetalol into amniotic fluid and breast milk in lactating women.

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12 December 2020

[Hemodynamic effects of labetalol on the humeral artery of the hypertensive patient. A double-blind study versus placebo]

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12 December 2020

The use of labetalol for attenuation of the hypertensive response to endotracheal intubation in preeclampsia

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12 December 2020

Fever induced by labetalol

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12 December 2020

The effects of treatments with labetalol and hydrochlorothiazide on ventilatory function of asthmatic hypertensive patients with demonstrated bronchosensitivity to propranolol

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12 December 2020

Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta

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12 December 2020

A comparison of labetalol and prazosin combined with atenolol in non-responders to atenolol plus hydrochlorothiazide in uncomplicated hypertension

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12 December 2020

Effect of labetalol on human platelet function

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12 December 2020

Labetalol in the treatment of stable exertional angina pectoris: a comparison with nifedipine

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12 December 2020

Haemodynamic dose-response effects of intravenous labetalol in acute myocardial infarction

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12 December 2020

Drug Kinetics and Hepatic Blood Flow

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12 December 2020

Hemodynamic effects of labetalol in patients with combined hypertension and left ventricular failure

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12 December 2020

Cold sensitivity in essential hypertension: the effect of beta- and combined alpha- and beta-blockade

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12 December 2020

The disposition and dynamics of labetalol in patients on dialysis

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12 December 2020

Low starting dose labetalol--a new approach for the elderly hypertensive

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12 December 2020

Effects of Labetalol on Plasma Renin, Aldosterone, and Catecholamines in Hypertensive Patients

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12 December 2020

The use of labetalol in Japan: results of multicentre clinical trials

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12 December 2020

Clinical evaluation of labetalol alone and combined with chlorthalidone in essential hypertension: a double-blind multicentre controlled study

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12 December 2020

Labetalol by continuous intravenous infusion in severe hypertension

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12 December 2020

The Combined Alpha- and Beta-Adrenergic Blocker Labetalol and Propranolol in the Treatment of High Blood Pressure: Similarities and Differences

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12 December 2020

Labetalol: bioavailability, drug plasma levels, plasma renin and catecholamines in acute and chronic treatment of resistant hypertension

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12 December 2020

Labetalol-induced toxic myopathy

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12 December 2020

Labetalol in general practice: a review

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12 December 2020

Effects of combined alpha and beta adrenoceptor blockade in patients with angina pectoris. A double blind study comparing labetalol with placebo

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12 December 2020

"Third drug" trial: comparative study of antihypertensive agents added to treatment when blood pressure remains uncontrolled by a beta blocker plus thiazide diuretic

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12 December 2020

Comparison of the effects of single doses of atenolol and labetalol on airways obstruction in patients with hypertension and asthma

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12 December 2020

Treatment of hypertension in the elderly with labetalol

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12 December 2020

Effects of combined alpha- and beta-receptor blockade on peripheral circulation in essential hypertension

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12 December 2020

Changes in blood pressure and thermographic values resulting from use of a beta-blocker plus diuretic and of an alpha-beta-blocker plus diuretic.

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12 December 2020

Labetalol does not alter the placental and fetal blood flow or maternal prostanoids in pre-eclampsia.

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12 December 2020

Alpha-adrenoceptor blockade by labetalol during long-term dosing

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12 December 2020

Treatment of hypertension following endotracheal intubation. A study comparing the efficacy of labetalol, practolol and placebo

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12 December 2020

Pharmacological basis for antihypertensive effects of intravenous labetalol

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12 December 2020

Evolution of renal function under chronic oral administration of labetalol

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12 December 2020

Renal haemodynamics after chronic treatment with labetalol and propranolol

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12 December 2020

Comparison of beta-adrenoceptor blockers and calcium antagonists in hypertension

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12 December 2020

Effect of single doses of labetalol, metoprolol, and placebo on ventilatory function in patients with bronchial asthma: interaction with isoproterenol

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12 December 2020

Prolactin stimulation by intravenous labetalol is mediated inside the central nervous system

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12 December 2020

Clinical Evaluation of Intravenous Labetalol for the Treatment of Hypertensive Urgency

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12 December 2020

Labetalol blockade of central α- and β-noradrenergic receptors in rat brain homogenates

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12 December 2020

Effect of labetalol on indices of myocardial necrosis in patients with suspected acute infarction

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12 December 2020

A comparison of labetalol, acebutolol, and lidocaine for controlling the cardiovascular responses to endotracheal intubation for oral surgical procedures

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12 December 2020

The short term effects of propranolol, atenolol and labetalol on antipyrine kinetics in normal subjects

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12 December 2020

Side-effects with long-term labetalol: an open study of 251 patients in a single centre

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12 December 2020

Review of long-term treatment with labetalol

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12 December 2020

Intravenous labetalol for treatment of postoperative hypertension.

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12 December 2020

The effect of labetalol on contractility of human myometrial preparations

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12 December 2020

Mean steady-state plasma concentrations of labetalol in patients undergoing antihypertensive therapy

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12 December 2020

The response of plasma catecholamines to intravenous labetalol: a comparison with sodium nitroprusside

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12 December 2020

I.v. labetalol in the treatment of hypertension following coronary-artery surgery

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12 December 2020

A comparative study of the effects of adrenoceptor antagonists on platelet aggregation and thromboxane generation

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12 December 2020

Hemodynamic effects of intravenous labetalol in essential hypertension.

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12 December 2020

Endocrine and Metabolic Effects of Labetalol in Man

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12 December 2020

Raynaud's phenomenon caused by beta-receptor blocking drugs. Improvement after treatment with a combined alpha- and beta-blocker

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12 December 2020

Effect of labetalol and propranolol on human cutaneous vasoconstrictor response to adrenaline

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12 December 2020

Cutaneous reaction to labetalol

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12 December 2020

Effects of labetalol on left ventricular mass and function in hypertension — An assessment by serial echocardiography

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12 December 2020

Systemic and coronary hemodynamics of labetalol in normotensive patients with ischemic heart disease.

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12 December 2020

Hypertension in pregnancy: evaluation of two beta blockers atenolol and labetalol

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12 December 2020

Some haemodynamic effects of compound AH 5158 compared with propranolol, propranolol plus hydrallazine, and diazoxide: the use of AH 5158 in the treatment of hypertension

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12 December 2020

Hemodynamic effects of labetalol in healthy volunteers

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12 December 2020

Beneficial effect of labetalol in hypertensive patients with angina pectoris.

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12 December 2020

Intrinsic sympathomimetic activity of labetalol

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12 December 2020

Combined labetalol plus flunarizine treatment for arterial hypertension

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12 December 2020

Effect of labetalol on plasma catecholamines at rest and during increased sympathetic activity

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12 December 2020

Role of labetalol in acute myocardial infarction

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12 December 2020

Comparison of labetalol and propranolol in hypertension

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12 December 2020

The influence of food on the oral and intravenous pharmacokinetics of a high clearance drug: a study with labetalol

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12 December 2020

Chronic effects of labetalol, pindolol, and propranolol on calf blood flow in intermittent claudication.

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12 December 2020

A comparative trial of labetalol and hydralazine in the acute management of severe hypertension complicating pregnancy

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12 December 2020

Decreased first-pass metabolism of labetalol in chronic liver disease

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12 December 2020

Labetalol, a combined alpha- and beta-blocker, in hypertension of pregnancy.

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12 December 2020

Properties of labetalol, a combined alpha- and beta-blocking agent, relevant to the treatment of myocardial ischemia

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12 December 2020

Comparative haemodynamic dose response effects of propranolol and labetalol in coronary heart disease

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12 December 2020

Intravenous labetalol in the treatment of severe hypertension and hypertensive emergencies

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12 December 2020

Response of the systemic pulmonary circulation to labetalol at rest and during exercise

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12 December 2020

Experience with labetalol in hypertension.

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12 December 2020

Comparison of labetalol and clonidine in hypertension

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12 December 2020

Comparative effects of adimolol, labetalol and propranolol on heart rate and blood pressure in man.

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12 December 2020

A long-term study of labetalol in general practice

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12 December 2020

Single-dose pharmacokinetics of labetalol in healthy young men

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12 December 2020

Long-term use of labetalol

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12 December 2020

Comparison of labetalol and dihydralazine in hypertensive emergencies of pregnancy.

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12 December 2020

Oral labetalol in the management of stable angina pectoris in normotensive patients

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12 December 2020

Drug therapy in patients undergoing peritoneal dialysis. Clinical pharmacokinetic considerations

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12 December 2020

A comparison of labetalol plus hospitalization versus hospitalization alone in the management of preeclampsia remote from term

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12 December 2020

Monotherapy with labetalol compared with propranolol. Differential effects by race

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12 December 2020

Long-term experiences with labetalol.

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12 December 2020

Labetalol and hydrochlorothiazide in hypertension. Labetalol/Hydrochlorothiazide Multicenter Study Group

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12 December 2020

Magnitude and mechanisms of the antihypertensive action of labetalol, including ambulatory assessment

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12 December 2020

Labetalol therapy in patients with systemic hypertension and angina pectoris: effects of combined alpha and beta adrenoceptor blockade

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12 December 2020

Effects of labetalol and propranolol on the peripheral circulation in hypertensive patients.

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12 December 2020

Some further evidence for partial agonist activity of labetalol

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12 December 2020

An analysis of the blood pressure response to labetalol in hypertensive patients

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12 December 2020

Labetalol in the treatment of patients with hypertension and renal function impairment

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12 December 2020

Intravenous labetalol in severe hypertension

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12 December 2020

Propranolol vs metoprolol vs labetalol: a comparative study in essential hypertension

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12 December 2020

Antihypertensive and metabolic effects of increasing doses of atenolol and labetalol. A comparative study in primary hypertension

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12 December 2020

Labetalol: A Review of Its Pharmacology, Pharmacokinetics, Clinical Uses and Adverse Effects

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12 December 2020

Improved liquid-chromatographic assay of labetalol in plasma

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12 December 2020

Induced hypotension with labetalol for orthognathic surgery

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12 December 2020

Hemodynamic and coronary effects of intravenous labetalol in coronary artery disease.

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12 December 2020

Comparison of the clinical pharmacokinetics and concentration-effect relationships for medroxalol and labetalol

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12 December 2020

Double-blind trial comparing labetalol with atenolol in the treatment of systemic hypertension with angina pectoris

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12 December 2020

Use of labetalol in trauma

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12 December 2020

Intravenous labetalol in the management of resistant hypertensive emergency.

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12 December 2020

A comparison of glyceryl trinitrate and labetalol as hypotensive agents in microsurgery of the middle ear.

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12 December 2020

Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings]

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12 December 2020

Labetalol: a review of its pharmacology and therapeutic use in hypertension

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12 December 2020

Rising multiple-dose pharmacokinetics of labetalol in hypertensive patients

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12 December 2020

Labetalol in resistant hypertension.

1 reference

12 December 2020

[Maternal effects and perinatal safety of labetalol in the treatment of hypertension in pregnancy. Comparison with methyldopa in a randomized cooperative trial]

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12 December 2020

[Arterial hypertension in the elderly. Double-blind study versus placebo of the efficacy and tolerability of an alpha-beta blocker: labetalol]

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12 December 2020

Treatment of severe hypertension with intravenous labetalol

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12 December 2020

Comparison of labetalol and prazosin in hypertensive patients using automated ambulatory monitoring

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12 December 2020

Effect of indoramin, labetalol and alinidine on sympathetic function in normal man.

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12 December 2020

Antihypertensive effectiveness of intravenous labetalol in accelerated hypertension

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12 December 2020

Labetalol in the treatment of elderly patients with mild essential hypertension

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12 December 2020

A comparison of the effects of combined or separate alpha- and beta-blockade in the treatment of hypertension in the acute stage of myocardial infarction

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12 December 2020

Haemodynamic and metabolic effects of combined adrenergic alpha- and beta-receptor blockade with labetalol in the exercising human forearm.

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12 December 2020

Diazoxide and labetalol in acute hypertension during haemodialysis

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12 December 2020

Pharmacological characterization of the presynaptic alpha-adrenoceptors regulating cholinergic activity in the guinea-pig ileum

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12 December 2020

On the combination of alpha- and beta-adrenoceptor blockade in hypertension

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12 December 2020

Intravenous labetalol in the management of severe hypertension and hypertensive emergencies

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12 December 2020

Beta blockade by oral propranolol and labetalol

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12 December 2020

Multiclinic comparison of labetalol to metoprolol in treatment of mild to moderate systemic hypertension

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12 December 2020

Pharmacokinetics and pharmacodynamic studies of labetalol in hypertensive subjects

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12 December 2020

Influence of labetalol, propranolol and practolol in patients with asthma

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12 December 2020

Labetalol as a hypotensive agent for middle ear microsurgery.

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12 December 2020

Characterization and localization of [3H]-clonidine binding in membranes prepared from guinea-pig spleen

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12 December 2020

Comparison of the effects of propranolol and labetalol on renal haemodynamics at rest and during exercise in essential hypertension

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12 December 2020

Labetalol infusion in hypertensive emergencies

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12 December 2020

Effects of long-term therapy with labetalol on lipoprotein metabolism in patients with mild hypertension

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12 December 2020

Effects of chronic alpha and beta adrenoceptor blockade with labetalol on plasma catecholamines and renal function in hypertension

1 reference

12 December 2020

Direct vasodilatation by labetalol in anaesthetized dogs

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12 December 2020

Evaluation of I.V. labetalol for treatment of posttraumatic hyperdynamic state

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12 December 2020

Multicenter clinical evaluation of long-term efficacy and safety of labetalol in treatment of hypertension

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12 December 2020

Circulatory effects of labetalol during halothane anaesthesia

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12 December 2020

A double-blind comparison of verapamil and labetalol in hypertensive patients with coexisting chronic obstructive airways disease

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12 December 2020

Acute Hemodynamic Effects of Labetalol in Severe Hypertension

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12 December 2020

Effect of labetalol on preload in acute myocardial infarction with systemic hypertension.

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12 December 2020

Study of single and multiple dose pharmacokinetic/pharmacodynamic modeling of the antihypertensive effects of labetalol

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12 December 2020

Pharmacokinetics of labetalol in healthy volunteers

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12 December 2020

Bioavailability of labetalol increases with age.

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12 December 2020

Labetalol, beta blockers, and acute deterioration of chronic airway obstruction.

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12 December 2020

Diazoxide vs labetalol: a cross-over comparison of short-term effects in hypertension

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12 December 2020

Comparison of the effects of labetalol and hydrochlorothiazide on the ventilatory function of hypertensive patients with mild chronic obstructive pulmonary disease

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12 December 2020

Labetalol disposition and concentration-effect relationships during pregnancy

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12 December 2020

Antihypertensive and metabolic effects of nifedipine and labetalol alone and in combination in primary hypertension.

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12 December 2020

A study of labetalol in patients of European, West Indian and West African origin

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12 December 2020

Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors

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12 December 2020

Acute effect of labetalol on blood pressure in relation to the sympathetic nervous system and plasma renin activity

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12 December 2020

The alpha- and beta-adrenoceptor blocking potencies of labetalol and its individual stereoisomers in anaesthetized dogs and in isolated tissues

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12 December 2020

Clinical Pharmacokinetics of Labetalol

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12 December 2020

Labetalol infusion in acute myocardial infarction with systemic hypertension

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12 December 2020

10.2165/00003495-198937050-00002

Identifiers

DOI

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Dimensions Publication ID

5 September 2017

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