(Q38714811)

English

Crocin Inhibits Oxidative Stress and Pro-inflammatory Response of Microglial Cells Associated with Diabetic Retinopathy Through the Activation of PI3K/Akt Signaling Pathway

scientific article published on 25 February 2017

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

5 September 2017

Crocin Inhibits Oxidative Stress and Pro-inflammatory Response of Microglial Cells Associated with Diabetic Retinopathy Through the Activation of PI3K/Akt Signaling Pathway (English)

1 reference

Europe PubMed Central

5 September 2017

microglial inhibitor

0 references

1 reference

based on heuristic

inferred from title

diabetic retinopathy

1 reference

based on heuristic

inferred from title

author name string

Xinguang Yang

1

1 reference

Europe PubMed Central

5 September 2017

Fuquan Huo

2

1 reference

Europe PubMed Central

5 September 2017

Bei Liu

3

1 reference

Europe PubMed Central

5 September 2017

Jing Liu

4

1 reference

Europe PubMed Central

5 September 2017

Tao Chen

5

1 reference

Europe PubMed Central

5 September 2017

Junping Li

6

1 reference

Europe PubMed Central

5 September 2017

Zhongqiao Zhu

7

1 reference

Europe PubMed Central

5 September 2017

Bochang Lv

8

1 reference

Europe PubMed Central

5 September 2017

publication date

25 February 2017

1 reference

Europe PubMed Central

5 September 2017

Journal of Molecular Neuroscience

1 reference

Europe PubMed Central

5 September 2017

61

1 reference

Europe PubMed Central

5 September 2017

4

1 reference

Europe PubMed Central

5 September 2017

581-589

1 reference

Europe PubMed Central

5 September 2017

https://scigraph.springernature.com/pub.10.1007/s12031-017-0899-8

0 references

Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Early microglia activation in a mouse model of chronic glaucoma

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Evaluation of antibody-dependent cell cytotoxicity using lactate dehydrogenase (LDH) measurement

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Inflammatory neurodegeneration and mechanisms of microglial killing of neurons

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

The pathobiology of diabetic complications: a unifying mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Synapse remodeling, compliments of the complement system

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Microglia: biology and pathology

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

The role of microglia in diabetic retinopathy

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Diabetic retinopathy: targeting vasoregression

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Effect of linalool on morphine tolerance and dependence in mice.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Botanical compounds: effects on major eye diseases

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Microglia and central nervous system immunity.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Tetramethylpyrazine, a natural alkaloid, attenuates pro-inflammatory mediators induced by amyloid β and interferon-γ in rat brain microglia

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Crocin Upregulates CX3CR1 Expression by Suppressing NF-κB/YY1 Signaling and Inhibiting Lipopolysaccharide-Induced Microglial Activation

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Saffron supplement maintains morphology and function after exposure to damaging light in mammalian retina

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Protective effect of saffron extract and crocin on reactive oxygen species-mediated high glucose-induced toxicity in PC12 cells

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Retinal ganglion cell neuronal damage in diabetes and diabetic retinopathy.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Crocin prevents retinal ischaemia/reperfusion injury-induced apoptosis in retinal ganglion cells through the PI3K/AKT signalling pathway

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Crocin suppresses tumor necrosis factor-alpha-induced cell death of neuronally differentiated PC-12 cells

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Time-dependent retinal ganglion cell loss, microglial activation and blood-retina-barrier tightness in an acute model of ocular hypertension.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Phosphorylation of Akt Mediates Anti-Inflammatory Activity of 1-p-Coumaroyl β-D-Glucoside Against Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Microglia instruct subventricular zone neurogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Neuroprotective effects of crocin against traumatic brain injury in mice: Involvement of notch signaling pathway.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA.

1 reference

https://api.crossref.org/works/10.1007%2FS12031-017-0899-8

21 January 2018

MiR-378 overexpression attenuates high glucose-suppressed osteogenic differentiation through targeting CASP3 and activating PI3K/Akt signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early reduction of microglia activation by irradiation in a model of chronic glaucoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetic retinopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophages: their myelinotrophic or neurotoxic actions depend upon tissue oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thioredoxin Binding Protein-2 Regulates Autophagy of Human Lens Epithelial Cells under Oxidative Stress via Inhibition of Akt Phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinopathy, glucose, and insulin in an elderly population. The Rotterdam Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crocin suppresses LPS-stimulated expression of inducible nitric oxide synthase by upregulation of heme oxygenase-1 via calcium/calmodulin-dependent protein kinase 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crocin protects retinal ganglion cells against H2O2-induced damage through the mitochondrial pathway and activation of NF-κB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saffron and natural carotenoids: Biochemical activities and anti-tumor effects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28238066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12031-017-0899-8

1 reference

Europe PubMed Central

5 September 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

5 September 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q38714811&oldid=2107709194"