(Q38722026)

English

Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins

scientific article published on 10 January 2017

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins (English)

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

phosphorylation

0 references

molecular chaperones

0 references

10

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

author name string

Ran Li

1

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Fengjie Yuan

2

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Wan Fu

3

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Luyao Zhang

4

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Nan Zhang

5

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Yanan Wang

6

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Ke Ma

7

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Xue Li

8

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Lina Wang

9

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Ying Zhao

11

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

language of work or name

0 references

publication date

10 January 2017

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

292

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

7

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

2830-2841

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Structural and functional basis of protein phosphatase 5 substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Autophagy at the crossroads of catabolism and anabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Hidden behind autophagy: the unconventional roles of ATG proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Beclin-1 is required for chromosome congression and proper outer kinetochore assembly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Autophagy suppresses interleukin-1β (IL-1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

The role of Atg proteins in autophagosome formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

AMPK-dependent phosphorylation of ULK1 induces autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Autophagy and the Integrated Stress Response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

The role of the Atg1/ULK1 complex in autophagy regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Regulation mechanisms and signaling pathways of autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Akt and CHIP coregulate tau degradation through coordinated interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Hierarchy of Atg proteins in pre-autophagosomal structure organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Molecular chaperones and protein kinase quality control.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

23 June 2018

ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

31 August 2018

Cdc37: a protein kinase chaperone?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5314178

31 August 2018

Overlapping sites of tetratricopeptide repeat protein binding and chaperone activity in heat shock protein 90

1 reference

https://pubmed.ncbi.nlm.nih.gov/28073914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M116.762443

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 February 2018

http://europepmc.org/abstract/PMC/5314178

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q38722026&oldid=1780520635"