(Q38773880)

6 September 2017

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title

Biology of the protein kinase C family (English)

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6 September 2017

C A O'Brian

1

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6 September 2017

N E Ward

series ordinal

2

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6 September 2017

publication date

1 December 1989

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Cancer and Metastasis Reviews

6 September 2017

published in

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6 September 2017

volume

8

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6 September 2017

issue

3

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6 September 2017

page(s)

199-214

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Inositol phospholipids and cell surface receptor function

6 September 2017

cites work

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https://api.crossref.org/works/10.1007%2FBF00047337

Inositol trisphosphate and diacylglycerol: two interacting second messengers

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00047337

The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047337

A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047337

Mechanisms of multidrug resistance and implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047337

Purification of phosphatidylinositol-specific phospholipase C from rat liver

21 January 2018

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12 December 2020

Vinculin, a cytoskeletal substrate of protein kinase C.

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12 December 2020

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12 December 2020

The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.

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12 December 2020

The complete primary structure of protein kinase C--the major phorbol ester receptor

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12 December 2020

The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes

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12 December 2020

Partial down-regulation of protein kinase C in C3H 10T 1/2 mouse fibroblasts transfected with the human Ha-ras oncogene

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12 December 2020

Phosphorylation of the 20,000-dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase. Phosphorylation sites and effects of phosphorylation

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12 December 2020

ras-transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites

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12 December 2020

Transient protection of cultured human cells against antitumor agents by 12-O-tetradecanoylphorbol-13-acetate.

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12 December 2020

Calcium as an intracellular mediator of hormone action: intracellular phospholipid signaling systems.

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12 December 2020

Inositol phospholipids and cell surface receptor function

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12 December 2020

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

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12 December 2020

Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements

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12 December 2020

ras GTPase activating protein: signal transmitter and signal terminator

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12 December 2020

Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase

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12 December 2020

Cysteine-rich regions conserved in amino-terminal halves of raf gene family products and protein kinase C

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12 December 2020

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

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12 December 2020

Role of specific interactions between protein kinase C and triphenylethylenes in inhibition of the enzyme

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12 December 2020

Epidermal growth factor binding and protein kinase C activities in human breast cancer cell lines: possible quantitative relationship

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12 December 2020

Circumvention of multiple-drug resistance in human cancer cells by thioridazine, trifluoperazine, and chlorpromazine.

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12 December 2020

Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells.

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12 December 2020

A monoclonal antibody recognising the site of limited proteolysis of protein kinase C. Inhibition of down-regulation in vivo.

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12 December 2020

Phorbol ester and epidermal growth factor receptors in human breast cancer

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12 December 2020

Subcellular distribution of protein kinase C in rat colonic epithelial cells with different proliferative activities

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12 December 2020

Triphenylethylenes: a new class of protein kinase C inhibitors

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12 December 2020

Inositol phosphates: synthesis and degradation

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12 December 2020

Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21

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12 December 2020

The regulation of protein kinase C by chenodeoxycholate, deoxycholate and several structurally related bile acids.

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12 December 2020

The bile acid analog fusidic acid can replace phosphatidylserine in the activation of protein kinase C by 12-O-tetradecanoylphorbol 13-acetate in vitro

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12 December 2020

Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter

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12 December 2020

Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats

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12 December 2020

Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid

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12 December 2020

Phorbol ester induction of 8-lipoxygenase in inbred SENCAR (SSIN) but not C57BL/6J mice correlated with hyperplasia, edema, and oxidant generation but not ornithine decarboxylase induction

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12 December 2020

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

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12 December 2020

Determination of tamoxifen and biologically active metabolites in human breast tumours and plasma

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12 December 2020

Calcium-independent activation of hypothalamic type I protein kinase C by unsaturated fatty acids

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12 December 2020

Antiproliferative properties of phorbol ester tumour promoters

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12 December 2020

Activation of rat brain protein kinase C by lipid oxidation products

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12 December 2020

Studies and perspectives of protein kinase C.

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12 December 2020

Cloning and expression of multiple protein kinase C cDNAs

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12 December 2020

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. I. Purification and general properties

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12 December 2020

Effects of tumor promoters on growth and on cellular redistribution of phospholipid/Ca2+-dependent protein kinase in human breast cancer cells

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12 December 2020

Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells

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12 December 2020

Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue

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12 December 2020

Phorbol esters induce multidrug resistance in human breast cancer cells

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12 December 2020

Binding of protein kinase C to napthalenesulfonamide- and phenothiazine-agarose columns: evidence for direct interactions between protein kinase C and cationic amphiphilic inhibitors of the enzyme

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12 December 2020

Purification to homogeneity of protein kinase C from bovine brain-identity with the phorbol ester receptor

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12 December 2020

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C

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12 December 2020

Phorbol esters inhibit the proliferation of MCF-7 cells. Possible implication of protein kinase C

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12 December 2020

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca2+-Dependent Protein Kinase

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12 December 2020

Activation of protein kinase C by non-phorbol tumor promoter, mezerein

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12 December 2020

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

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12 December 2020

Protein kinase C phosphorylates human platelet inositol trisphosphate 5'-phosphomonoesterase, increasing the phosphatase activity

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12 December 2020

Effect of tamoxifen, a nonsteroidal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary

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12 December 2020

Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain

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12 December 2020

Overproduction of protein kinase C causes disordered growth control in rat fibroblasts

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12 December 2020

Decreased protein kinase C activity in psoriatic versus normal epidermis

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12 December 2020

Tumor promoter phorbol 12-myristate 13-acetate induces a clastogenic factor in human lymphocytes

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12 December 2020

Studies on protein kinase C and colon carcinogenesis

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12 December 2020

31 Calcium-activated, phospholipid-dependent protein kinase (protein kinase C) from rat brain

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12 December 2020

Selective activation of the gamma-subspecies of protein kinase C from bovine cerebellum by arachidonic acid and its lipoxygenase metabolites

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12 December 2020

In vitro inhibition of rat brain protein kinase C by rhodamine 6G. Profound effects of the lipid cofactor on the inhibition of the enzyme

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12 December 2020

Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase

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12 December 2020

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

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12 December 2020

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA.

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12 December 2020

Activation of protein kinase C by tumor promoting phorbol esters, teleocidin and aplysiatoxin in the absence of added calcium

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12 December 2020

Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis

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12 December 2020

Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60.

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12 December 2020

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase

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12 December 2020

Further characterization of tumor-promoter-mediated activation of protein kinase C

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12 December 2020

Specific and direct binding of protein kinase C to an immobilized tamoxifen analogue

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12 December 2020

Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: Teleocidin and debromoaplysiatoxin

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12 December 2020

Receptors for epidermal growth factor and other polypeptide mitogens

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12 December 2020

Purification and characterization of three types of protein kinase C from rabbit brain cytosol

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12 December 2020

Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium.

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12 December 2020

Regulatory mechanisms in the control of protein kinases.

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12 December 2020

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain

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12 December 2020

Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase

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12 December 2020

Binding of protein kinase C to N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide through its ATP binding site

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12 December 2020

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

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12 December 2020

Potential tumor-promoting activity of bile acids in rat glandular stomach

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12 December 2020

The cytosolic phorboid receptor correlates with hormone dependency in six mammary carcinoma cell lines

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12 December 2020

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

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12 December 2020

Calcium and phospholipid-dependent protein kinase activity in mouse epidermis cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds

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12 December 2020

Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine

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12 December 2020

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

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12 December 2020

Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases

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12 December 2020

Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell

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12 December 2020

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity

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12 December 2020

Promoting effect of bile acids on the chemical transformation of C3H/10T1/2 fibroblasts in vitro.

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12 December 2020

Protein kinase C phosphorylates pp60src at a novel site.

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12 December 2020

Protein kinase C catalyzes phosphorylation of guanylate cyclase in vitro

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12 December 2020

Down-regulation of protein kinase C and of an endogenous 80-kDa substrate in transformed fibroblasts.

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12 December 2020

Synthesis of a substrate of protein kinase C and its corresponding phosphopeptide.

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12 December 2020

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

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12 December 2020

Studies of the mechanism of action and regulation of cAMP-dependent protein kinase

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12 December 2020

A thousand and one protein kinases

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12 December 2020

Magnetic resonance studies of the effect of the regulatory subunit on metal and substrate binding to the catalytic subunit of bovine heart protein kinase

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12 December 2020

Promoting Effect of Sodium Deoxycholate on Colon Adenocarcinomas in Germfree Rats2

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12 December 2020

Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids

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12 December 2020

Tamoxifen in advanced breast cancer

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12 December 2020

Inositol 1,3,4,5-tetrakisphosphate induces Ca2+ sequestration in rat liver cells

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12 December 2020

Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase.

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12 December 2020

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease

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12 December 2020

Immunochemical identification of protein kinase C isozymes as products of discrete genes

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12 December 2020

Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways

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12 December 2020

Inhibition of protein kinase C by tamoxifen

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12 December 2020

Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family

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12 December 2020

Nutrition in the prevention of neoplastic disease in the elderly

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12 December 2020

Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells

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12 December 2020

Role of protein kinase C in phosphorylation of vinculin in adriamycin-resistant HL-60 leukemia cells.

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12 December 2020

Absence of protein kinase C in nuclei of EL4 mouse thymoma cells

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12 December 2020

Immunological quantitation of phospholipid/Ca2+-dependent protein kinase of human mammary carcinoma cells: inverse relationship to estrogen receptors

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12 December 2020

Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells

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12 December 2020

Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product

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12 December 2020

Substrate specificity of phospholipid/Ca2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein

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12 December 2020

Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas

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12 December 2020

Identifiers

DOI

10.1007/BF00047337

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Dimensions Publication ID

6 September 2017

1049468287

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