(Q38775522)

6 September 2017

Clipping the Wings of Glioblastoma: Modulation of WNT as a Novel Therapeutic Strategy (English)

1 reference

6 September 2017

1 reference

Abigail K Suwala

1

1 reference

6 September 2017

Allison Hanaford

series ordinal

2

1 reference

6 September 2017

Ulf D Kahlert

series ordinal

3

1 reference

6 September 2017

Jaroslaw Maciaczyk

series ordinal

4

1 reference

6 September 2017

15 March 2016

1 reference

Journal of Neuropathology & Experimental Neurology

6 September 2017

1 reference

6 September 2017

75

1 reference

6 September 2017

5

1 reference

6 September 2017

388-396

1 reference

Evolution of the Karnosky Performance Status throughout life in glioblastoma patients.

6 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Survival effect of first- and second-line treatments for patients with primary glioblastoma: a cohort study from a prospective registry, 1997-2010.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Survival outcome of early versus delayed bevacizumab treatment in patients with recurrent glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Brain tumor stem cells: Molecular characteristics and their impact on therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Effect of Notch expression in glioma stem cells on therapeutic response to chemo-radiotherapy in recurrent glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Essential role of the Hedgehog signaling pathway in human glioma-initiating cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Isolation and characterization of cancer stem like cells in human glioblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Differential profiling studies of N-linked glycoproteins in glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

The role of NFAT transcription factors in integrin-mediated carcinoma invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt/beta-catenin signaling in oral tissue development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Alternative wnt signaling is initiated by distinct receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

β-Catenin-dependent pathway activation by both promiscuous "canonical" WNT3a-, and specific "noncanonical" WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 dependency

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Ryk is essential for Wnt-5a-dependent invasiveness in human glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and MMP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Potential canonical wnt pathway activation in high-grade astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Identification of human brain tumour initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

The multifaceted role of MTDH/AEG-1 in cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt activation is implicated in glioblastoma radioresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/β-catenin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Upregulation of Wnt5a promotes epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Induction and regulation of epithelial-mesenchymal transitions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Glioblastoma multiforme formation and EMT: role of FoxM1 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

An overview of epithelio-mesenchymal transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

O2 regulates stem cells through Wnt/β-catenin signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt activation promotes neuronal differentiation of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt-5a has tumor suppressor activity in thyroid carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-κB-inducing kinase (NIK) and noncanonical NF-κB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Role of Wnt5a in the proliferation of human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

APC mutations in sporadic medulloblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Downregulation of WIF-1 by hypermethylation in astrocytomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt inhibitory factor-1 regulates glioblastoma cell cycle and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Epigenetic regulation of wnt pathway antagonists in human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

DNA demethylation reactivates a subset of imprinted genes in uniparental mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Casein kinase 2α regulates glioblastoma brain tumor-initiating cell growth through the β-catenin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt/beta-Catenin pathway in human glioma: expression pattern and clinical/prognostic correlations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

β-catenin and Gli1 are prognostic markers in glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Proteomic analysis of cerebrospinal fluid: toward the identification of biomarkers for gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Canonical Wnt pathway inhibitor ICG-001 induces cytotoxicity of multiple myeloma cells in Wnt-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Structure-activity relationship and properties optimization of a series of quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Phase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

The Aurora kinases inhibitor VE-465 is a novel treatment for glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Aurora-A inhibition offers a novel therapy effective against intracranial glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

AURKA governs self-renewal capacity in glioma-initiating cells via stabilization/activation of β-catenin/Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Antitumor effect of aspirin in glioblastoma cells by modulation of β-catenin/T-cell factor-mediated transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Nuclear translocation of β-catenin is essential for glioma cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

A phase I trial of enzastaurin in patients with recurrent gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Synergistic antiglioma activity of radiotherapy and enzastaurin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

BASI, a potent small molecular inhibitor, inhibits glioblastoma progression by targeting microRNA-mediated β-catenin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Regulation of glycogen synthase kinase-3 beta (GSK-3β) by the Akt pathway in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

GSK3β regulates Bcl2L12 and Bcl2L12A anti-apoptosis signaling in glioblastoma and is inhibited by LiCl

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

WNT signalling pathways as therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Regulation of mesenchymal stromal cells through fine tuning of canonical Wnt signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Making new contacts: the mTOR network in metabolism and signalling crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Wnt-Notch signalling crosstalk in development and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Current Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible Crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

A method to determine the ability of drugs to diffuse through the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Over-expression of ROR2 and Wnt5a cooperatively correlates with unfavorable prognosis in patients with non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2FNLW013

21 January 2018

Identifiers

DOI

10.1093/JNEN/NLW013

1 reference

6 September 2017

1 reference