(Q38779945)

6 September 2017

title

Toxin-antitoxin systems in bacterial growth arrest and persistence (English)

1 reference

6 September 2017

Rebecca Page

1

1 reference

6 September 2017

Wolfgang Peti

series ordinal

2

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6 September 2017

publication date

1 March 2016

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6 September 2017

published in

Nature Chemical Biology

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6 September 2017

volume

12

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6 September 2017

issue

4

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6 September 2017

page(s)

208-214

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https://scigraph.springernature.com/pub.10.1038/nchembio.2044

6 September 2017

exact match

0 references

cites work

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Hypothetical functions of toxin-antitoxin systems

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Mini-F plasmid genes that couple host cell division to plasmid proliferation

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Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells

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Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained

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Toxins-antitoxins: diversity, evolution and function

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Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system

21 January 2018

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Lon-dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid-free segregant bacteria.

21 January 2018

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Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution

21 January 2018

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Bacterial persistence as a phenotypic switch

21 January 2018

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Bacterial persistence: a model of survival in changing environments

21 January 2018

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Mechanism of killer gene activation. Antisense RNA-dependent RNase III cleavage ensures rapid turn-over of the stable hok, srnB and pndA effector messenger RNAs

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

sRNAs in bacterial type I and type III toxin-antitoxin systems

21 January 2018

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Multiple hok genes on the chromosome of Escherichia coli

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison-antidote system

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

MazF Cleaves Cellular mRNAs Specifically at ACA to Block Protein Synthesis in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Doc toxin is a kinase that inactivates elongation factor Tu

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Molecular mechanism of bacterial persistence by HipA.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Three Dimensional Structure of the MqsR:MqsA Complex: A Novel TA Pair Comprised of a Toxin Homologous to RelE and an Antitoxin with Unique Properties

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

RelE toxins from bacteria and Archaea cleave mRNAs on translating ribosomes, which are rescued by tmRNA.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

YoeB-ribosome structure: a canonical RNase that requires the ribosome for its specific activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Characterization of YafO, an Escherichia coli toxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Molecular basis of ribosome recognition and mRNA hydrolysis by the E. coli YafQ toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Structure of the Proteus vulgaris HigB-(HigA)2-HigB Toxin-Antitoxin Complex

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Defining the mRNA recognition signature of a bacterial toxin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The Crystal Structure of the Intact E. coli RelBE Toxin-Antitoxin Complex Provides the Structural Basis for Conditional Cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

A novel family of Escherichia coli toxin-antitoxin gene pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Bacterial persistence by RNA endonucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

HipBA-promoter structures reveal the basis of heritable multidrug tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Internalization of Salmonella by macrophages induces formation of nonreplicating persisters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Molecular mechanisms underlying bacterial persisters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Bacterial toxin-antitoxin systems: Translation inhibitors everywhere

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Doc of Prophage P1 Is Inhibited by Its Antitoxin Partner Phd through Fold Complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Structural basis for protein phosphatase 1 regulation and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Intrinsically disordered proteins in cellular signalling and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Sequences and topology: disorder, modularity, and post/pre translation modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The solution structure of ParD, the antidote of the ParDE toxin-antitoxin module, provides the structural basis for DNA and toxin binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Intrinsically disordered segments affect protein half-life in the cell and during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Disorder- and dynamics-based regulatory mechanisms in toxin-antitoxin modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Conditional cooperativity of toxin - antitoxin regulation can mediate bistability between growth and dormancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Mechanisms of Toxin Inhibition and Transcriptional Repression by Escherichia coli DinJ-YafQ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Structure of the Escherichia coli Antitoxin MqsA (YgiT/b3021) Bound to Its Gene Promoter Reveals Extensive Domain Rearrangements and the Specificity of Transcriptional Regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Activated ClpP kills persisters and eradicates a chronic biofilm infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Structural Basis of mRNA Recognition and Cleavage by Toxin MazF and Its Regulation by Antitoxin MazE in Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Structural and functional analysis of the kid toxin protein from E. coli plasmid R1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

Co-evolution of quaternary organization and novel RNA tertiary interactions revealed in the crystal structure of a bacterial protein-RNA toxin-antitoxin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2044

The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family

21 January 2018

1 reference

12 December 2020

Corepression of the P1 addiction operon by Phd and Doc.

1 reference

12 December 2020

Mechanism of post-segregational killing: Sok antisense RNA interacts with Hok mRNA via its 5'-end single-stranded leader and competes with the 3'-end of Hok mRNA for binding to the mok translational initiation region

1 reference

12 December 2020

Antitoxin MqsA helps mediate the bacterial general stress response

1 reference

12 December 2020

The Bacterial Toxin RelE Displays Codon-Specific Cleavage of mRNAs in the Ribosomal A Site

1 reference

12 December 2020

hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.2044

1 reference

6 September 2017

1 reference