(Q38849610)

English

Chronic oxidative stress causes estrogen-independent aggressive phenotype, and epigenetic inactivation of estrogen receptor alpha in MCF-7 breast cancer cells

scientific article published on 26 July 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

7 September 2017

Chronic oxidative stress causes estrogen-independent aggressive phenotype, and epigenetic inactivation of estrogen receptor alpha in MCF-7 breast cancer cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

1 reference

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author name string

Prathap Kumar S Mahalingaiah

1

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

Logeswari Ponnusamy

2

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

Kamaleshwar P Singh

3

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

language of work or name

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publication date

26 July 2015

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Europe PubMed Central

PubMed publication ID

7 September 2017

Breast Cancer Research and Treatment

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Europe PubMed Central

PubMed publication ID

7 September 2017

153

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Europe PubMed Central

PubMed publication ID

7 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

41-56

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

https://scigraph.springernature.com/pub.10.1007/s10549-015-3514-0

0 references

Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

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Estrogen receptor silencing induces epithelial to mesenchymal transition in human breast cancer cells

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Estrogen receptor signaling as a target for novel breast cancer therapeutics.

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Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cells

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Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer

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Estrogen receptor transcription and transactivation: Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action

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Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase

1 reference

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21 January 2018

Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells

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21 January 2018

Phosphorylation of ERK1/2 mitogen-activated protein kinase is associated with poor response to anti-hormonal therapy and decreased patient survival in clinical breast cancer

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Cracking the estrogen receptor's posttranslational code in breast tumors

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MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer

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MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1

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Distinct mechanisms of loss of estrogen receptor alpha gene expression in human breast cancer: methylation of the gene and alteration of trans-acting factors.

1 reference

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Oxidative stress pathways highlighted in tumor cell immortalization: association with breast cancer outcome

1 reference

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Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy

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Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase

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Chronic oxidative stress increases growth and tumorigenic potential of MCF-7 breast cancer cells

1 reference

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Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers

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Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells

1 reference

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Mechanisms of hormonal therapy resistance in breast cancer

1 reference

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Antineoplastic action of 5-aza-2'-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells

1 reference

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21 January 2018

The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor alpha-negative breast cancer cells to tamoxifen

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Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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21 January 2018

Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cells

1 reference

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21 January 2018

The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study

1 reference

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21 January 2018

A phosphorylation code for oestrogen receptor-alpha predicts clinical outcome to endocrine therapy in breast cancer

1 reference

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21 January 2018

miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer

1 reference

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21 January 2018

MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer

1 reference

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21 January 2018

An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples.

1 reference

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21 January 2018

Hypoxia reduces hormone responsiveness of human breast cancer cells

1 reference

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Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells

1 reference

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Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

1 reference

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21 January 2018

Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis

1 reference

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Role of oxidative stress and the microenvironment in breast cancer development and progression

1 reference

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Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells

1 reference

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Epigenetic information and estrogen receptor alpha expression in breast cancer

1 reference

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Epigenetic regulation of estrogen signaling in breast cancer

1 reference

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Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling

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Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers.

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Nuclear control of respiratory gene expression in mammalian cells

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Expression of mitochondrial transcription factor A in endometrial carcinomas: clinicopathologic correlations and prognostic significance

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Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

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Oxidant stress impaired DNA-binding of estrogen receptor from human breast cancer

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Epigallocatechin gallate induces telomere fragmentation in HeLa and 293 but not in MRC-5 cells

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Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer

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Promoter methylation status and expression of estrogen receptor alpha in familial breast cancer patients.

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Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells

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Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells.

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Demethylation of promoter C region of estrogen receptor alpha gene is correlated with its enhanced expression in estrogen-ablation resistant MCF-7 cells

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MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

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The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming

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The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells.

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Emerging connections between DNA methylation and histone acetylation.

1 reference

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Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor α

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ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line

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10.1007/S10549-015-3514-0

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

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