(Q38878480)

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The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.

scientific article published on 7 May 2015

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25947085%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1 (English)

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7 March 2020

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7 March 2020

Ruey-Hwang Chou

5

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7 March 2020

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7 March 2020

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Ling-Chu Chang

1

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7 March 2020

Yung-Luen Yu

2

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7 March 2020

Chin-Yu Liu

3

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7 March 2020

Min-Tsang Hsieh

6

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7 March 2020

Hui-Yi Lin

7

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7 March 2020

Hsin-Yi Hung

8

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7 March 2020

Li-Jiau Huang

9

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7 March 2020

Sheng-Chu Kuo

11

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7 March 2020

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7 May 2015

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7 March 2020

Cancer Chemotherapy and Pharmacology

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7 March 2020

75

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7 March 2020

6

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7 March 2020

1303-1315

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7 March 2020

Cancer statistics, 2015

1 reference

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Differences in practice patterns and costs between small cell and non-small cell lung cancer patients in Japan

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On and around microtubules: an overview

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Microtubule-binding agents: a dynamic field of cancer therapeutics

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Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues

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21 January 2018

Microtubule-targeted anticancer agents and apoptosis

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21 January 2018

Microtubules in apoptosis induction: are they necessary?

1 reference

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21 January 2018

Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis

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21 January 2018

CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?

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21 January 2018

Mammalian cyclin-dependent kinases

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21 January 2018

Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe.

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21 January 2018

Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins

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21 January 2018

Biological properties of citrus flavonoids pertaining to cancer and inflammation

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21 January 2018

Two mitosis-specific antibodies, MPM-2 and phospho-histone H3 (Ser28), allow rapid and precise determination of mitotic activity.

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21 January 2018

Cell cycle checkpoints: preventing an identity crisis

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21 January 2018

DNA breaks and chromosome pulverization from errors in mitosis

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21 January 2018

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

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21 January 2018

Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

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The role of MAPK pathways in the action of chemotherapeutic drugs

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Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2.

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21 January 2018

Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity

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The cellular geography of aurora kinases

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21 January 2018

Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents

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21 January 2018

Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis

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21 January 2018

Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

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21 January 2018

Role of JNK activation in apoptosis: a double-edged sword

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21 January 2018

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

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21 January 2018

JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint.

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21 January 2018

Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration

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21 January 2018

Cell death: critical control points

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How do microtubule-targeted drugs work? An overview

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21 January 2018

Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs)

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21 January 2018

Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics

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21 January 2018

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

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Phosphorylation of FADD is critical for sensitivity to anticancer drug-induced apoptosis

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Changes in FADD levels, distribution, and phosphorylation in TNFalpha-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent

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10.1007/S00280-015-2765-0

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7 March 2020

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7 March 2020

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