(Q38885079)

7 September 2017

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title

The epidermal growth factor receptor pathway in chronic kidney diseases (English)

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7 September 2017

Laura R Harskamp

1

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7 September 2017

Ron T Gansevoort

series ordinal

2

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7 September 2017

Harry van Goor

series ordinal

3

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7 September 2017

Esther Meijer

series ordinal

4

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7 September 2017

language of work or name

English

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publication date

4 July 2016

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Nature Reviews Nephrology

7 September 2017

published in

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7 September 2017

volume

12

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7 September 2017

issue

8

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7 September 2017

page(s)

496-506

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The epidermal growth factor (EGF).

7 September 2017

cites work

1 reference

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ErbB receptors: directing key signaling networks throughout life

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Expression of epidermal growth factor and its receptor in normal and diseased human kidney: an immunohistochemical and in situ hybridization study

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Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

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Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia

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ErbB4 modulates tubular cell polarity and lumen diameter during kidney development

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Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types

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Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation.

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Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form

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Betacellulin-induced beta cell proliferation and regeneration is mediated by activation of ErbB-1 and ErbB-2 receptors

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Cloning and biological activity of epigen, a novel member of the epidermal growth factor superfamily

21 January 2018

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Transformation of polarized epithelial cells by apical mistrafficking of epiregulin

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EGFR signaling in renal fibrosis

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Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker

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Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury

21 January 2018

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Urinary EGF Receptor Ligand Excretion in Patients with Autosomal Dominant Polycystic Kidney Disease and Response to Tolvaptan

21 January 2018

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Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

The epidermal growth factor receptor ligands at a glance

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Regulation of glucose transporter (GLUT1) gene expression by angiotensin II in mesangial cells: involvement of HB-EGF and EGF receptor transactivation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research

21 January 2018

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Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study

21 January 2018

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Renal epithelial injury and fibrosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

EGFR signaling promotes TGFβ-dependent renal fibrosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Novel Epidermal Growth Factor Receptor Inhibitor Attenuates Angiotensin II-Induced Kidney Fibrosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

EGFR signaling in podocytes at the root of glomerular disease

21 January 2018

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Epidermal growth factor receptor inhibition with erlotinib ameliorates anti-Thy 1.1-induced experimental glomerulonephritis.

21 January 2018

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Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Renal epidermal growth factor receptor: its role in sodium and water homeostasis in diabetic nephropathy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

EGF receptor deletion in podocytes attenuates diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Epidermal growth factor inhibition, a novel pathway to prevent chronic allograft injury.

21 January 2018

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International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Epidermal growth factor receptor expression in human renal allograft biopsies: an immunohistochemical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Cystic and inherited kidney diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

A case for water in the treatment of polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

In vitro formation and expansion of cysts derived from human renal cortex epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Small-molecule inhibitors of the receptor tyrosine kinases: promising tools for targeted cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

mTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Effect of TNF-alpha--converting enzyme inhibitor on insulin resistance in fructose-fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

ADAM17, shedding, TACE as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Inhibition of heparin-binding epidermal growth factor-like growth factor increases albuminuria in puromycin aminonucleoside nephrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Erlotinib preserves renal function and prevents salt retention in doxorubicin treated nephrotic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Tyrosine kinase signaling in fibrotic disorders: Translation of basic research to human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Electrolyte disorders related to EGFR-targeting drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

ADAM-17: the enzyme that does it all.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

ADAM17 as a therapeutic target in multiple diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Role of growth factors in acute renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Growth factors and apoptosis in acute renal injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Distribution of heparin-binding EGF-like growth factor protein and mRNA in the normal rat kidneys

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Role of G proteins in stimulation of Na-H exchange by cell shrinkage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Specific endothelial heparin-binding EGF-like growth factor deletion ameliorates renal injury induced by chronic angiotensin II infusion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Heparin-binding epidermal growth factor-like growth factor is expressed in the adhesive lesions of experimental focal glomerular sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

HB-EGF release mediates glucose-induced activation of the epidermal growth factor receptor in mesangial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Increased epidermal growth factor in experimental diabetes related kidney growth in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Renal dysfunction but not cystic change is ameliorated by neonatal epidermal growth factor in bpk mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Monoclonal antibody therapy of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2016.91

In situ hybridization of prepro-epidermal growth factor mRNA in the mouse kidney

31 March 2020

1 reference

12 December 2020

Identification and localization of epidermal growth factor and its receptor in the human glomerulus

1 reference

12 December 2020

Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues

1 reference

12 December 2020

Serum Inflammatory and Immune Mediators Are Elevated in Early Stage Diabetic Nephropathy

1 reference

12 December 2020

Renal cysts in transgenic mice expressing transforming growth factor-alpha

1 reference

12 December 2020

Immunohistochemical study of epidermal growth factor receptor (EGFR) in various types of renal injury

1 reference

12 December 2020

Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program.

1 reference

12 December 2020

Expression of the c-erbB-3 protein in normal human adult and fetal tissues

1 reference

12 December 2020

A historical perspective of the EGF receptor and related systems.

1 reference

12 December 2020

Metanephric transforming growth factor-alpha is required for renal organogenesis in vitro

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12 December 2020

Emerging strategies for ErbB ligand-based targeted therapy for cancer.

1 reference

12 December 2020

EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRNEPH.2016.91

1 reference

Dimensions Publication ID

7 September 2017

1000017048

0 references

1 reference