(Q388855)

English

Toll like receptor 3

mammalian protein found in Homo sapiens

uniprot:O15455
toll-like receptor 3
TLR3

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

toll-like receptor

0 references

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15455

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15455

toll-like receptor 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15455

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

identical protein binding

determination method

3 references

8 April 2019

The TLR3 signaling complex forms by cooperative receptor dimerization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

8 April 2019

Isolated Toll-like receptor transmembrane domains are capable of oligomerization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

8 April 2019

Toll-like receptor 3 transmembrane domain is able to perform various homotypic interactions: an NMR structural study

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

double-stranded RNA binding

determination method

4 references

17 October 2017

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15455&geneProductId=UniProtKB:O15455

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15455&geneProductId=UniProtKB:O15455

determination method

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15455&geneProductId=UniProtKB:O15455

determination method

17 October 2017

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15455&geneProductId=UniProtKB:O15455

determination method

double-stranded RNA binding

determination method

5 references

8 April 2019

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

8 April 2019

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

signaling receptor activity

determination method

1 reference

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

A family of human receptors structurally related to Drosophila Toll

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

lysosomal membrane

determination method

1 reference

17 October 2017

Integral and associated lysosomal membrane proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15455&geneProductId=UniProtKB:O15455

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

endolysosome membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

endosome membrane

determination method

2 references

extracellular space

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

intracellular anatomical structure

determination method

1 reference

1 January 2018

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15455&geneProductId=UniProtKB:O15455

determination method

lysosomal membrane

determination method

1 reference

8 April 2019

Integral and associated lysosomal membrane proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

extracellular matrix

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

biological process

response to dsRNA

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

defense response

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of toll-like receptor signaling pathway

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of protein phosphorylation

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15455&geneProductId=UniProtKB:O15455

determination method

male gonad development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of type III interferon production

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

cellular response to interferon-beta

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

response to exogenous dsRNA

determination method

negative regulation of osteoclast differentiation

determination method

1 reference

8 April 2019

Stimulation by toll-like receptors inhibits osteoclast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of cytokine production

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

response to virus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

activation of NF-kappaB-inducing kinase activity

determination method

1 reference

8 April 2019

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

I-kappaB phosphorylation

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of JNK cascade

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

hyperosmotic response

determination method

1 reference

8 April 2019

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

cellular response to dsRNA

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15455&geneProductId=UniProtKB:O15455

determination method

regulation of dendritic cell cytokine production

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

microglial cell activation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

TRIF-dependent toll-like receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

cellular response to mechanical stimulus

determination method

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

microglial cell activation involved in immune response

determination method

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15455&geneProductId=UniProtKB:O15455

determination method

positive regulation of gene expression

determination method

defense response to bacterium

determination method

1 reference

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

defense response to virus

determination method

necroptotic signaling pathway

determination method

1 reference

8 April 2019

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of interleukin-8 production

determination method

1 reference

8 April 2019

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

cellular response to exogenous dsRNA

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

cellular response to interferon-gamma

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

detection of virus

determination method

1 reference

8 April 2019

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

inflammatory response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

innate immune response

determination method

3 references

I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of type I interferon production

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

signal transduction

determination method

3 references

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

8 April 2019

A family of human receptors structurally related to Drosophila Toll

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

apoptotic signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

negative regulation of MyD88-independent toll-like receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

extrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of angiogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

positive regulation of NIK/NF-kappaB signaling

determination method

1 reference

8 April 2019

Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15455

determination method

Gene Atlas image

PBB GE TLR3 206271 at fs.png
732 × 530; 12 KB

0 references

http://purl.uniprot.org/uniprot/O15455

1 reference

Identifiers.org

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000296795

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000296795

ENSP00000423684

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423684

ENSP00000423386

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423386

1 reference

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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