(Q38896398)

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Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion

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scholarly article

1 reference

Europe PubMed Central

7 September 2017

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion (English)

1 reference

Europe PubMed Central

7 September 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

L Sleire

1

1 reference

Europe PubMed Central

7 September 2017

B S Skeie

2

1 reference

Europe PubMed Central

7 September 2017

I A Netland

3

1 reference

Europe PubMed Central

7 September 2017

H E Førde

4

1 reference

Europe PubMed Central

7 September 2017

E Dodoo

5

1 reference

Europe PubMed Central

7 September 2017

F Selheim

6

1 reference

Europe PubMed Central

7 September 2017

L Leiss

7

1 reference

Europe PubMed Central

7 September 2017

J I Heggdal

8

1 reference

Europe PubMed Central

7 September 2017

P-H Pedersen

9

1 reference

Europe PubMed Central

7 September 2017

J Wang

10

1 reference

Europe PubMed Central

7 September 2017

P Ø Enger

11

1 reference

Europe PubMed Central

7 September 2017

language of work or name

0 references

publication date

23 March 2015

1 reference

Europe PubMed Central

7 September 2017

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Europe PubMed Central

7 September 2017

34

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Europe PubMed Central

7 September 2017

49

1 reference

Europe PubMed Central

7 September 2017

5951-5959

1 reference

Europe PubMed Central

7 September 2017

https://scigraph.springernature.com/pub.10.1038/onc.2015.60

0 references

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Regulation of cancer cell metabolism

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

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Reactive oxygen species: a breath of life or death?

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor- B via c-SRC and Oxidant-Dependent Cell Death

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Ionizing radiation activates the Nrf2 antioxidant response

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Glutamate transporters in the biology of malignant gliomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Autocrine glutamate signaling promotes glioma cell invasion.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Excitotoxic destruction facilitates brain tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Glutamate release by primary brain tumors induces epileptic activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Increased xCT expression correlates with tumor invasion and outcome in patients with glioblastomas.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Sulphasalazine in Rheumatoid Arthritis: An Old Drug Revived

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

CONTROLLED TRIAL OF SULPHASALAZINE IN THE TREATMENT OF ULCERATIVE COLITIS.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Inhibition of cystine uptake disrupts the growth of primary brain tumors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Hypoxia increases the dependence of glioma cells on glutathione

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Survival in glioblastoma: historical perspective.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Cognitive functioning in long-term survivors of high-grade glioma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

A European Organisation for Research and Treatment of Cancer phase III trial of adjuvant whole-brain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality-o

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

γ knife surgery versus reoperation for recurrent glioblastoma multiforme.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Adjuvant gamma knife stereotactic radiosurgery at the time of tumor progression potentially improves survival for patients with glioblastoma multiforme

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Sulfasalazine-induced reduction of glutathione levels in breast cancer cells: enhancement of growth-inhibitory activity of Doxorubicin.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Sulfasalazine and temozolomide with radiation therapy for newly diagnosed glioblastoma.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Multicellular tumor spheroids from human gliomas maintained in organ culture

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Angiogenesis-independent tumor growth mediated by stem-like cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

Electric cell-substrate impedance sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

A reproducible brain tumour model established from human glioblastoma biopsies

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.60

31 March 2020

[Experimental radiosurgery in rats using gamma a "gamma knife". Description of a stereotactic device for small laboratory animals]

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of human and rat glioma cells grown in a defined medium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a human GBM xenograft model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25798841

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/ONC.2015.60

1 reference

Europe PubMed Central

7 September 2017

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0 references

1 reference

Europe PubMed Central

7 September 2017

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