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Degradation of SAMHD1 by Vpx Is Independent of Uncoating
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
4442547
retrieved
7 September 2017
title
Degradation of SAMHD1 by Vpx Is Independent of Uncoating
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4442547
retrieved
7 September 2017
author
Paula Jáuregui
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
author name string
Eric C Logue
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
Megan L Schultz
series ordinal
3
1 reference
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Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
Stephanie Fung
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4
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Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
Nathaniel R Landau
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
language of work or name
English
0 references
publication date
11 March 2015
1 reference
stated in
Europe PubMed Central
PMCID
4442547
retrieved
7 September 2017
published in
Journal of Virology
1 reference
stated in
Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
volume
89
1 reference
stated in
Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
issue
10
1 reference
stated in
Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
page(s)
5701-5713
1 reference
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Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
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ImageJ
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11 June 2022
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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4442547/fullTextXML
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HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation
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SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
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HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.
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Aicardi-Goutieres syndrome: from patients to genes and beyond
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Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase
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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
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9 September 2017
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
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9 September 2017
Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon
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9 September 2017
Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription
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9 September 2017
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
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Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells
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Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response
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The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection
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Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection
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9 September 2017
Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication
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9 September 2017
Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1.
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9 September 2017
A conserved dileucine-containing motif in p6(gag) governs the particle association of Vpx and Vpr of simian immunodeficiency viruses SIV(mac) and SIV(agm)
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9 September 2017
Interaction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentiviruses
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9 September 2017
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition
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9 September 2017
Vpx of simian immunodeficiency virus is localized primarily outside the virus core in mature virions.
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9 September 2017
Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein
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9 September 2017
Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.
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9 September 2017
The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating.
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9 September 2017
A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest
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9 September 2017
The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.
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9 September 2017
Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization
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Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites.
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Identification of capsid mutations that alter the rate of HIV-1 uncoating in infected cells
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Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins
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17 June 2018
Human cytosolic extracts stabilize the HIV-1 core
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17 June 2018
HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore
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17 June 2018
The kinetics of human immunodeficiency virus reverse transcription are slower in primary human macrophages than in a lymphoid cell line
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17 June 2018
Identifiers
DOI
10.1128/JVI.03575-14
1 reference
stated in
Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
PMCID
4442547
1 reference
stated in
Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
PubMed ID
25762741
1 reference
stated in
Europe PubMed Central
PMCID
4442547
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25762741%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 June 2020
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