(Q38915658)

7 September 2017

title

The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity (English)

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7 September 2017

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Quan Li

1

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7 September 2017

Moe Yokoshi

series ordinal

2

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7 September 2017

Hitomi Okada

series ordinal

3

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7 September 2017

Yukio Kawahara

series ordinal

4

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7 September 2017

language of work or name

English

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publication date

29 January 2015

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7 September 2017

published in

Nature Communications

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7 September 2017

volume

6

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7 September 2017

page(s)

6183

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https://scigraph.springernature.com/pub.10.1038/ncomms7183

7 September 2017

exact match

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cites work

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Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease

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Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

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Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

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Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

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Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.

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TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage

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Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases.

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Molecular properties of TAR DNA binding protein-43 fragments are dependent upon its cleavage site

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Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

21 January 2018

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Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

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Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function

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Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)

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TDP-43 toxicity proceeds via calcium dysregulation and necrosis in aging Caenorhabditis elegans motor neurons

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Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

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Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.

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21 January 2018

1 reference

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Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7183

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS7183

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Dimensions Publication ID

7 September 2017

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1022414785

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1 reference