(Q38926249)

7 September 2017

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title

Anti-Influenza Treatment: Drugs Currently Used and Under Development (English)

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7 September 2017

Luciano Amarelle

1

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7 September 2017

Emilia Lecuona

series ordinal

2

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7 September 2017

Jacob I Sznajder

series ordinal

3

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7 September 2017

publication date

9 August 2016

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Archivos de Bronconeumologia

7 September 2017

published in

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7 September 2017

volume

53

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7 September 2017

issue

1

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7 September 2017

page(s)

19-26

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Structure and mechanism of the M2 proton channel of influenza A virus

7 September 2017

cites work

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12 December 2020

Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol

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12 December 2020

Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells

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12 December 2020

Conformational changes required for reovirus cell entry are sensitive to pH.

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12 December 2020

Influenza C virus infection in military recruits--symptoms and clinical manifestation

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12 December 2020

Aerosol therapy of influenza infections of mice and primates with rimantadine, ribavirin, and related compounds

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12 December 2020

A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response

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12 December 2020

Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice

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12 December 2020

Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice

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12 December 2020

Mechanism of action of T-705 against influenza virus

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12 December 2020

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12 December 2020

The cap-binding site of influenza virus protein PB2 as a drug target.

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12 December 2020

Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA.

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12 December 2020

Zinc- and pH-dependent conformational transition in a putative interdomain linker region of the influenza virus matrix protein M1.

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12 December 2020

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

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12 December 2020

A comprehensive map of the influenza A virus replication cycle

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12 December 2020

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin

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12 December 2020

Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection.

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12 December 2020

Influenza virus genome consists of eight distinct RNA species

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12 December 2020

Comparative clinical and laboratory evaluation of the prophylactic capacity of ribavirin, amantadine hydrochloride, and placebo in induced human influenza type A

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12 December 2020

Activity of the neuraminidase inhibitor A-315675 against oseltamivir-resistant influenza neuraminidases of N1 and N2 subtypes

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12 December 2020

A broadly neutralizing human monoclonal antibody directed against a novel conserved epitope on the influenza virus H3 hemagglutinin globular head

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12 December 2020

Influenza virus proteins. I. Analysis of polypeptides of the virion and identification of spike glycoproteins

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12 December 2020

Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol

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12 December 2020

Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity

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12 December 2020

Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.

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12 December 2020

Cell fusion by Semliki Forest, influenza, and vesicular stomatitis viruses

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12 December 2020

Design, Synthesis, and Molecular Docking of Novel Pyrrolooxazepinediol Derivatives with Anti-Influenza Neuraminidase Activity

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12 December 2020

Clinical efficacy of arbidol (umifenovir) in the therapy of influenza in adults: preliminary results of the multicenter double-blind randomized placebo-controlled study ARBITR

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12 December 2020

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium

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12 December 2020

Influenza virus-host interactome screen as a platform for antiviral drug development

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12 December 2020

Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly

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12 December 2020

Amantadine selection of a mutant influenza virus containing an acid-stable hemagglutinin glycoprotein: evidence for virus-specific regulation of the pH of glycoprotein transport vesicles

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12 December 2020

Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014.

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12 December 2020

Glycyrrhizin inhibits influenza A virus uptake into the cell

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12 December 2020

Stepwise priming by acidic pH and a high K+ concentration is required for efficient uncoating of influenza A virus cores after penetration

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12 December 2020

Hsp90 inhibitors reduce influenza virus replication in cell culture

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12 December 2020

Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor

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12 December 2020

MEK inhibition impairs influenza B virus propagation without emergence of resistant variants

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12 December 2020

Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade

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12 December 2020

The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)

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12 December 2020

Effectiveness of antiviral treatment in human influenza A(H5N1) infections: analysis of a Global Patient Registry.

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12 December 2020

Polypeptides specified by the influenza virus genome I. Evidence for eight distinct gene products specified by fowl plague virus

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12 December 2020

Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor

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12 December 2020

T-705 (favipiravir) activity against lethal H5N1 influenza A viruses

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12 December 2020

Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus

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12 December 2020

Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach

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12 December 2020

ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells

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12 December 2020

Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1.

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12 December 2020

New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion

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12 December 2020

Membrane fusion activity of influenza virus.

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12 December 2020

Sialic acid-mimic peptides as hemagglutinin inhibitors for anti-influenza therapy

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12 December 2020

The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.

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12 December 2020

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

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12 December 2020

Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo

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12 December 2020

Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro

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12 December 2020

Structure-based design of novel naproxen derivatives targeting monomeric nucleoprotein of Influenza A virus

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12 December 2020

Effects of spontaneous bilayer curvature on influenza virus-mediated fusion pores

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12 December 2020

A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection

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12 December 2020

Cap and Internal Nucleotides of Reovirus mRNA Primers Are Incorporated into Influenza Viral Complementary RNA During Transcription In Vitro

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12 December 2020

Novel influenza virus NS1 antagonists block replication and restore innate immune function

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12 December 2020

Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity

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12 December 2020

New influenza A Virus Entry Inhibitors Derived from the Viral Fusion Peptides.

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12 December 2020

Role of N Terminus-Truncated NS1 Proteins of Influenza A Virus in Inhibiting IRF3 Activation

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12 December 2020

Synthesis and anti-viral activity of azolo-adamantanes against influenza A virus

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12 December 2020

Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial

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12 December 2020

Conserved and host-specific features of influenza virion architecture

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12 December 2020

Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems

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12 December 2020

Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo.

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12 December 2020

Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level

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12 December 2020

Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada

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12 December 2020

A broad-spectrum antiviral targeting entry of enveloped viruses

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12 December 2020

Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium; the role of the host cell in selection of hemagglutinin receptor specificity

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12 December 2020

Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid

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12 December 2020

Binding of influenza A virus NS1 protein to dsRNA in vitro

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12 December 2020

NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation

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12 December 2020

Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport

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12 December 2020

Design, synthesis, and biological evaluation of crenatoside analogues as novel influenza neuraminidase inhibitors

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12 December 2020

Design, synthesis, and in vitro biological evaluation of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein

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12 December 2020

Clinical Implications of Antiviral Resistance in Influenza

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12 December 2020

Polyadenylation and reverse transcription of influenza viral RNA.

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12 December 2020

Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009

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12 December 2020

Production of Common Colds in Human Volunteers by Influenza C Virus

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12 December 2020

Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection

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12 December 2020

The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts

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12 December 2020

Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials

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12 December 2020

Genetic screens for the control of influenza virus replication: from meta-analysis to drug discovery.

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12 December 2020

Outcomes of adults hospitalised with severe influenza.

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12 December 2020

Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China.

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12 December 2020

The broad anti-viral agent glycyrrhizin directly modulates the fluidity of plasma membrane and HIV-1 envelope

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12 December 2020

Clinical Characteristics Are Similar across Type A and B Influenza Virus Infections.

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12 December 2020

Inhibitory effect of bafilomycin A1, a specific inhibitor of vacuolar-type proton pump, on the growth of influenza A and B viruses in MDCK cells

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12 December 2020

The polypeptide composition of influenza A viruses

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12 December 2020

Antiviral agents for the treatment and chemoprophylaxis of influenza --- recommendations of the Advisory Committee on Immunization Practices (ACIP).

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12 December 2020

Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit

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12 December 2020

Assembly and budding of influenza virus

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12 December 2020

Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2

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12 December 2020

Design of inhibitors of influenza virus membrane fusion: synthesis, structure-activity relationship and in vitro antiviral activity of a novel indole series

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12 December 2020

A phase II study of DAS181, a novel host directed antiviral for the treatment of influenza infection

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12 December 2020

Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice

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12 December 2020

Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments

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12 December 2020

In vitro characterization of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication

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12 December 2020

Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function

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12 December 2020

Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene.

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12 December 2020

Efficacy and safety of aerosolized ribavirin in young children hospitalized with influenza: a double-blind, multicenter, placebo-controlled trial

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12 December 2020

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections

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12 December 2020

Active NF-kappaB signalling is a prerequisite for influenza virus infection.

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12 December 2020

Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent

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12 December 2020

Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner

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12 December 2020

Differential activation of the influenza virus polymerase via template RNA binding

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12 December 2020

Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.

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12 December 2020

Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins

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12 December 2020

Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion

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12 December 2020

Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits

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12 December 2020

Clinical diagnosis of influenza virus infection: evaluation of diagnostic tools in general practice

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12 December 2020

Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses

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12 December 2020

Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses.

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12 December 2020

Aprotinin, a protease inhibitor, suppresses proteolytic activation of pandemic H1N1v influenza virus

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12 December 2020

10.1016/J.ARBR.2016.11.020

Identifiers

DOI

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7 September 2017

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